Drug Ratings for SERZONEAverage Rating: 3.2 (131 Ratings)
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Results are sorted by Date Rating Was Added Key to Ratings: 1=LOW (I would not recommend taking this medicine.) Page: 1 2 3 |
| RATING | REASON | SIDE EFFECTS FOR SERZONE | COMMENTS | SEX | AGE | DURATION/ DOSAGE | DATE ADDED |
  | F M | | | | |||
| 5 | panic, depression, o.c.thoughts | 2days of headache and brain zap a bit scary.Dr. said" don't give up. I didnt. This drug was sent from heaven. It took four weeks to fully work. Zero side effects after that rough period. Do not give up! It works. Every other one feels like drugs...serzone makes me feel NORMAL. | M | 35 | 2 years 50mgx2/day | 5/13/2013 | 1 | Panicky attacks and depression | Very frost, can't concentrate , have a hard time speaking , I have slow slurred speech.,this is the only antidepressent that has been so strong to make me feel like this.. | F | 43 | 2 months 150 | 4/12/2013 | 2 | CFS/Depression | 9 PM Dosing: Paradoxical insomnia despite fatigue. Hard come down, analogous to amphetamine. After a few hours, induced hypomania and empathic qualities, in line with its metabolism to mCPP. +6 hours body temperature elevation and sweating. | M | 26 | 1 days 200 1X D | 4/5/2013 | 5 | Major Depression | At first starting it I slept a day and had headache. Side effects soon went away. Since I only notice dry mouth and a little tired about an hour after a dose. | Wonderful anti-depressant. It not only treats depression but also the anxiety. Started at a low dose and was slowly increase to current 500 mg/day. I use Nefazodone and cannot function without it. Live in the U.S. and no problems getting it. I have a wonderful career in the medical field. Watch out for drug interactions. No liver problems. I get LFT annually. | F | 53 | 14 years 250 mg 2X D | 12/9/2012 | 5 | for deep depression | I didn't have any side effects. It saved my li i have been given everything nothing is working i was on it for over 20 yrs. please put it back on the market. | F | 50 | 1 days 200 | 10/2/2012 | 5 | Anxiety/Depression | None | I have been on this medication for 16 years was recently taken off of it to try different meds and have come to find this is what works for me. It controls my anxiety. | F | 32 | 16 years 200mg 1X D | 8/13/2012 | 1 | Depression | This drug was HORRIBLE for me, it ruined my life! Before this, I was highly intelligent, with a near-photographic memory. But my mind was so fuzzy on this drug that, when playing Scrabble with friends, I literally had to use a calculator when I was the scorekeeper! (Before this, I could literally multiply three 5-digit numbers in my head with ease.) I lost memory function on this med, and also lost actual memories. I've still never recovered, and find everything so much more difficult than it used to be. Plus, for the last month of taking it, I would get sudden, agonizing pain in my head that felt like an axe hitting me. Sooo glad this evil garbage is off the market! | F | 39 | 4 months dunno | 8/4/2012 | 5 | Had been on ALL anti-depressants | I took every morning. Serzone was the MIRACLE medication for me. It was black boxed and was put on Lexapro and gained 40 lbs. in two weeks. Finally found that Nefazodone was generic form of Serzone and have been taking since 2006. The problem now is there seems to be a shortage of Nefazodone. I can't seem to get the same answer from any pharmacies!! Have enough to last through Aug. by dividing higher dose to amt. I'm supposed to take. Knowing this med. is a class unlike the SSR. I'm afraid because tried going off with SSR's and totally messed me up. IMO, I will have to gradually taper IF the manufactor TEVA doesn't continue as they are the best imo. | Started Serzone Brand in 1999 and was like a new life had been granted to me. It surpassed ALL past anti-depressants and actually felt as close to being "normal' and not in a "high" or buzzed way. Such a shame it was taken off market. my liver tests were always fine but dosage was 150 mg. whcih was considered low dosage but super for me! | F | 54 | 150 1X D | 6/20/2012 | 5 | Major Depression | This made has been GREAT for me ! I take Nefazodone, here in the USA - When they pulled Brand Name Serzone, I switched right over to Nefazodone made by TEVA, it is same generic equivalent as Brand Name Serzone | I could not live, OR function without this Med. Folks, generic Nefazodone here in the USA by TEVA is same, and works just as good, I tried all others, and this is the ONLY Med that has worked to help me for 15 years, LIVER TEST fine so far after 15 years of 200mg daily | M | 41 | 15 years 100 2X D | 6/1/2012 | 5 | Severe Depression | Weight loss, nausea (you need to take it with food), drowsiness, restless legs. The side effects were worth it though. This drug really changed my life in so many ways. | This got discontinued from the world market and is no longer available. Unfortunately, this was the only antidepressant that has ever worked for me. I have tried over 20 types since and have not found a single one to work. I wish they would bring this back onto the market. | F | 29 | 2 years 200mg 2X D | 5/1/2012 | 5 | depression/anxiety/ fms | I NEED this medicine. I was told today by pharmacist that they were having trouble getting my rx filled, their suppliers were not going to carry it anymore. I am frightened. One dose missed and I am back to where I was when I was first diagnosed. I have tried other drugs. I have tried to get off of this medication. It makes me functional. It provides me with quality of life. I don't know what I will do if I do not have access to this medicine. The thought of going back to what I was before I started to take it frightens me more than the possible risk of liver damage. That can be monitored. I took 300 mg for many years. I hold stable at 75 mg a night. I don't want to lose my life again. It took me so long to get it all back together. | F | 40 | 10 years 75mg a day | 4/20/2012 | 5 | Depression/Anxiety | Serzone/Nefazadone is my Miracle Med for depression and anxiety! Unfortunately, I was just diagnosed with severe PTSD, traumatic experience. My psychiatrist and I decided it may benefit me to go to a psych hospital, in patient, for a few days for continual therapy and med tweaking. After 'in-take', Case Mgr assured me that I would continue on Serzone while there. I was admitted, only to find out the Psych Pharmacy did NOT have NOR would supply me with Serzone! I offered to drive home, (15 minutes away, pick up an unopened bottle of Serzone, return and give to Psych Pharmacy for dispensing)I was very calm in offering this suggestion and not presenting with any symptoms at all. Head Nurse said, "NO"!... and if you leave you will not have a bed to return to" I was ripping!..and I was the one who 'volunteered' myself 'in'. I LEFT! My question/s is: 1.) Why, we as lay people know, you can't just drop a med..it has to be tapered off and 2.) has anybody else had a problem with | F | 58 | 8 years 200MG 2X D | 3/11/2012 | 3 | anxiety/depression | Rage anger severe mood swings loss of memory feelings of being lost and scary thoughts | M | 36 | 10 years 400-500 | 3/1/2012 | 1 | Major Depressive disorder | F | 34 | 3 days 1X D | 1/24/2012 History | 5 | depression | The immediate 12 hours after taking the drug I had a headache and needed a long nap. After that, there were ABSOLUTELY NO SIDE EFFECTS for me. | Serzone has been unavailable in Canada now for a number of years. I have not been able to find a drug that even comes close the effectiveness of Serzone. I am very mad that they took it off the market because 0.0006% (4 out of 650,000) of the people experienced liver damage, that's not even close to a scientifically statistically significant amount. From what I've read the people who did experience liver damage were being prescribed double the recommended daily maximum. So because of a couple of stupid doctors they pulled the drug and the people who take it safely are punished. | F | 36 | 6 years 50mg 1X D | 11/6/2011 | 5 | Depression | Constipation, urinary retention, memory loss, but worth it. These are much easier to deal with than wanting to kill yourself. | Only thing that ever worked for me. SSRIs in general put me into an acute anxiety state. This drug pulled me out of serious, debilitating, depression. If you have a healthy liver and nothing else has worked, find a good doctor, start at a very low dose, and get liver screens once a month. | M | 46 | 4 years 600 MG 1X D | 6/29/2011 | 4 | depression | worked well, sleepiness, blurry vision, then the FDA black labeled it and my doctor said do not use. did not work on panic | M | 46 | 4 years 300 1X D | 8/18/2010 | 5 | depersonalization and depression | Weird visual trails (that were not too disconcerting). Some drowsiness (which helped to sleep). Significant withdrawl effects if I missed a couple of doses (weird hot flashes, night sweats and insomnia) | I was in complete remission on Serzone for several years and I for one would take it again in a heartbeat if it were still available in Canada (I have not ruled out getting the generic from the US). It's biggest benefits over other antidepressants are the fact that it has Zero negative effects on sex drive and sexual functioning AND it's weight neutral. Also I drank like a fish on it so if anyone, I should have had liver problems with it and never did. I wonder if there's more to the picture than meets the eye regarding the real reason (besides a few liver problems) it was pulled from the market. By the sounds of things it was a considerable benefit to many of us. Bring it back!! | M | 42 | 3 years 300 2X D | 8/6/2010 | 5 | anxiety; ideation of suicide. | None !!!! I feel perfectly normal - a WONDER drug. Saved my life. | I hope that more people have the same relief that I got from Serzone. Prozac had no effect. | M | 69 | 10 years 600 4X D | 8/2/2010 | 2 | Anxiety/depression | All day headache, extreme soreness in my neck, shoulder and back muscles, blank feeling, couldn't get words out, tiredness. | So far have not been able to find an antidepressant I can handle and really thought Serzone would work. Felt no benefit at all after three weeks and couldn't take the constant pain so am going to have to stop. | F | 39 | 22 days 100 2X D | 7/20/2010 | 5 | Depression | This will sound terrible, but compared to the effects I was having on SSRIs which had NO effect on my depression, this was nothing: Dry mouth, irritable bowel syndrome, blurred vision/visual trails, muscle weakness and coordination problems, extreme sleepiness 30-90 min after taking a dose (passed after about 90 min), feelings of intoxication, dilated pupils, slurred speech (v similar to being drunk - again this dissipated approx 90 min after the dose), ongoing memory and vision problems (6 years after stopping). | I loved Serzone. It was the only medication which had ANY effect on my depression. On other medication (Celexa, Zoloft, Aurorix) I had horrendous shakes and nightmares and no perceptible improvement in my depression. I wish it was still available to me. I was on 600mg/day (max dose). I went to 750mg/day when I had a bad period. I took 4 doses per day - 150mg per dose - the intoxicating effects were too severe if I took 300mg at once. I'd fall asleep at my desk and be unable to speak clearly. I took my last dose a few hours before I went to bed otherwise I'd wake up with a hangover. The coordination/muscle weakness was difficult and I put on a lot of weight. If I tried to stay out late the visual disturbances would be severe and my pupils would dilate so much that any light would be painful. I've been off it 6 years now but I think I've got lasting side effects. I have dilated pupils most of the time (although this could be due to the length of time I took antidepressants in general, not just Serzone, or the fact that I had an alcohol/marijuana abuse problem), my memory is terrible, my eyesight seems to be deteriorating more rapidly than seems normal, and occasionally I get what feel like Serzone flashbacks - I get the intoxicated feeling, the muscle weakness and the visual trails every now and then. Note that I am very sensitive to all medications so my side effects are on the severe end of the scale. They always are. | F | 33 | 2 years 600mg 4X D | 6/28/2010 | 5 | Depression, Anxiety | Dry mouth at first. None whatsoever to this day. | Life saver! Have tried Paxil, Prozac, Cymbalta and Prestiq and I always come back to old faithful. I no longer have ups and downs. Best of all I have no weight gain. I have a lessened sex drive but it's not gone all together.Everyone has their own chemical needs for depression, but this is the one and only for me and I highly recommend trying it to see if it's the one for you. I do have regular liver tests, but very, very few have had it affect their liver. I honestly owe my life to this drug. | F | 51 | 13 years 300mgs 2X D | 6/17/2010 | 1 | Mild Depression | Worst experience of my life!! Immediately had severe headache, severe nausea, my eyes were quickly dialating in and out which made me severely dizzy and gave me an "out of my head feeling' extremely scary. I thought I was going to die. I should have gone to the hospital immediatley but I was young and didnt know what to do. | I think this one may be off the market ... but if it is not... DO NOT TAKE IT!!! | F | 37 | 1 days ? 1X D | 3/15/2010 | 5 | Depression and anxiety | This is the "miracle drug" I had been looking for. 12 years ago when we found out that our Father was dying, I went straight to the doctor to get on an antidepressant. 12 years prior we had lost the 4th of our children. A beatiful little girl. I had always been raised to accept what God gives you and go on. Well that does not work. I COULD NOT get out of bed. I knew I had a problem when one day I over heard my oldest child, Jason ask his daddy, when he came home from work, one evening if he could stay home. He told his father that Momma never gets out of bed. I knew then I had to see a doctor. The doctor at that time gave me Prozac. So when I went prior to my father's death I asked for the same thimg. I was told by my wonderful doctor that Prozac is used when a person is really down to "bring them up" and serzone helps to keep you even and calm. He was right. After 8 years on it I decided on my own I was cured and tapered myself off of it. (Big mis | I never had any problems, but I did go on a regular basis for my liver function tests. I had no problems ever. Please listen carefully to your doctor's orders and report any and all problems to them, even if you think they are minor. They are there to help you, and they take special pride when they do. Good luck to you. | F | 58 | 8 years | 1/5/2010 | 5 | Depression and anxiety | None what so ever. Best medication I have ever taken. | I started on Zerson about 10 year ago. It was the miracle drug I was looking for. I also took it with Valium (5mg) 3 times a day. It worked so well for that for tje 8 years, I thought I was cured and eased myself off both. (Biggest mistake I made). About 6 months later the company I am working with sent me out of town. I went to see a couple of doctors there (this was about the time they were deciding to take it off the market). Long story short no one would prescribe it for me. I am back home and have just begun to get off of Effexor, which for me, has not been working. I can see the light at the end of the tunnel. My doctor gave in after seeing that nothing else was working for me. I will never get off this miracle drug again. No more stress, no more neck pain, no more headaches. Life is about to get great again. I will be honest and tell DO go and do my blood as needed. | F | 57 | 8 years | 12/25/2009 | 5 | depression /chronic daily headaches | no side effects at all really. no sexual side effects at therapeutic dosage of 200 mgs. I tried going up to 300 mgs and experienced a difficult time ejaculating, so i went back down to 200 mg. | this was a miracle drug for me because it cured my headaches and gave me a new outlook on life. I was on it for 8 years, then had a 2 year hiatus b/c I couldn't find a doc to prescribe it, but I am back on it again. I am willing to risk the liver issue (1 in 300,000) if I get my enzymes checked every 4 months. | M | 37 | 8 years | 12/17/2009 | 5 | Anxiety | Headaches when first starting and when increasing dosage - subsides after two weeks. | This drug has been a life saver for me. I had a panic attack four months ago and remaind in a hightend state of anxiety (couldn't sleep or eat, extreme nausea, very jittery, etc.) until I saw a psych who started me on Remeron. I went up to 45mg very quickly and it helped a bit but I wanted to eat everything in sight so he switched me to serzone - started at 200mg and went up to 300mg which is where I remain. I still have mild anxiety but it's very manageable. My mom has been on this drug for 10+ years with no side effects. I did have my liver checked when I first started taking it and will continue to have it checked every 6 months. I also continue to take 15mg of Remeron at night to help me sleep but will hopefully discontinue that soon. | F | 35 | 3 months | 12/11/2009 | 5 | anxiety | Some dry mouth, a bit of constipation, tiredness at first | I have been using this for about ten years, and it keeps me functioning. Severe stress made me up the dose from 300 to 400. Doctor said body can get good at processing it and make it less effective. I tried to change over when I heard it was going out of production, but had a horrible experience with the other drug. I am interested in hearing from other long time users. I am more forgetful, but I am also older, and have survived some truly horrible times. Stress takes its toll on memory. My eyesight is getting worse, but it often does when one ages. Meanwhile, it feels good to be myself, able to handle the incredible things that life throws at me without a breakdown. I have found that few doctors seem to know much about it. One doctor explained that if there are liver issues, they tend to happen in the early times of usage. I feel very safe. | F | 56 | 10 years | 12/7/2009 | 5 | Anxiety, couldn't drive nor travel | I only experienced needing to drink a lot of liquid do to dry mouth, but I needed to increase my fluid intake anyway. | I have been on every anti-depressant there is and Serzone is the only one that made me feel like a content, relaxed,human being,who was happy and could keep on track, who for the first time looked forward to traveling with my husband, who started driving all over by myself.Then.... My doc took me off when the black box warning came out..little did he realize that they all should have black box warnings on them for one reason or the other! I want to get back on it right now..I have been on 4 in the last 8 months and getting off and on them is horrendous!Those shooting electrical charges in my head from getting off those pills have fried my hair!I am eagerly looking for a Psychiatrist who will give me Serzone again, who wants to help his patients, not make them more afraid then they already are. | F | 60 | 3 years | 11/11/2009 | 5 | Panic/anxiety; Mod. Depression | At higher doses visual "trails" especially when getting up an night to urinate, but they are sort of neat actually. Mild anorgasmia (inability to orgasm)and mild emotional "deadening." | About the liver problem: Estimates indicate about 1 in 250,000 patient years will develop liver problems. If your urine turns brown, your stool (poop) starts to turn white or the whites of your eyes start to turn yellow, seek medical help. Get liver profile before and while taking especially in the beginning. It appears that the people that died may have had liver issues even before the Serzone made it worse. I cannot take SSRI's because my Cytochrome liver enzyme systems do not clear them causing a rapid toxic level. Serzone uses a different Cytochrome system which seems intact for me so it works well. Its effects are a bit subtle, but I get a good balance of relief and I find that I can drop to 200mg/day when my life has little stress, and increase to 600mg/day at high stress times like December with Christmas and reduced daylight. Unlike other meds one can drop dosage or increase dosage quite rapidly. I find that I can take a "drug holiday" and go for several days on half the dose, and then resume. This mediates any anorgasmia. I also like Nefazodone because it is a sleep moderator and I sleep better with it. When I take 300mg/day I take 200 before bedtime and 100 in the morning. If I need to take 400 I'll do 200 at night, 100 in the morning and 100 at lunch, otherwise I'll get mild lightheartedness. About 50 people have had liver problems over a decade and about 20 have died, I'll bet far more people have died from car accidents while using Nefazodone. | M | 56 | 10 years | 11/4/2009 | 1 | Panic Disorder | Hot flashes, chills, disoriented, loss of balance, could not walk in a straight line, worst panic attack of my life. | I have been on Wellbutrin SR 300 mg for two months. The Wellbutrin was not helping for my panic disorder so my Phychiatrist suggested adding Serzone. I took 50 mg before bed around 9:00 pm. Around 11:00 pm I started feeling unusually panicky. Shortly after the rest of the horrible side effects began. I have become very good at diffusing panic attacks when they occur, but this one was so severe I was not able to diffuse it at all. I read on the internet that the stuff takes between 11-24 hours to clear out of your system. I did not feel normal again until 5 pm the following day. Beware if you decide to try the Serzone/Wellbutrin combination. | F | 30 | 1 days | 10/22/2009 | 5 | acute OCD/anxiety | love this medication; saved my life. Just wondering now if it is starting to cause memory loss and memory recall difficulties(after 6 years of use) or if my dose is too high. Psychiatrist is sending me to a neurologist to confirm. | Been on the medication for 6-7 years now after living a debilitated life of constant anxiety, stiff neck, headaches, chronic physical/ verbal and emotional anger , acute OCD, and some paranoia. Finally allowed myself to take medication but refused to go on SSRIs as I did not want weight gain and/or sexual dysfunction. Nefazadone (the generic) after a month was the first time in my life that I could take a deep breath, literally. Small things did not send my mind spinning and I was finally calm enough to be silly and fun. People did not know who I was and I started to get invited to social events again. Wanted however to see if my problems with memory recall and trying to get things off "the tip of my tongue" were starting to result from the many years of use. Addtionally, wanted to see if the weight gain was due in part to the medication as well. Currently at 400mg (close to max) and was wondering if anyone else was experiencing the same. | F | 38 | 7 years | 9/16/2009 | 1 | Major Depression | I was a zombie | I felt absolutely no feelings at all--no depression and no happiness. Everything was a blur. I feel like I have chunks of time missing from that period in my life. | F | 30 | 3 months | 9/8/2009 | 5 | Anxiety/Depression | So far none that I can see, excfepyt it's a little harder gettinf to sleep at night | I took this drug back in 95 for 6 monmths and it worked well. Began taking it again a few months back doc has me on 50 mg x2 day and sees no need to up the dose. Took the edge off my anxiety and depression almost overnight. A low dose seems to work for me, liver functions before starting and recent;y are perfectly normal, but my doctor wil check them every 3 months The reason I asked for nefazodone is that I caould not tolerate any of the SSRI side effects | M | 62 | 3 months | 7/8/2009 | 1 | Depression | Didn't work. Made me fee worse. | F | 16 | 7 days | 6/14/2009 | 5 | anx/dep suicide ideation | None; anx. disappeared o'nite ( with the help of a little Xanax-only briefly- the "X" magnifies the Serzone, as far as anx. is concerned. I was very, very slightly buzzed for two weeks; then marvelous release of the mental torture / obsessions and hateful feelings. Prosac had no effect WSE. Great Psych. from Pakistan really saved my life ! Been on Serzone for 12 years now. My Mom and her brother (Uncle) had the same mental prob in the 40's(inherited). Uncle comm. suicide. Mom started on Valium in mid-50's - some help but needed shock-treatments once a year. This mental-disease cannot be understood by the "normal" community. They are very sympathetic, but always say, " Pull yourself by you're bootstaps. Breathe the roses. Drive your Rolls-Royce more. Drive those motorcycles !!" New shoes might help. They don't understand it's ( in my casa ) a "S" reuptake-problem ! Brain chemistry a little gone wrong. A new Phantom VII will not cure the p | God bless Merck. For people worrying about Serzone being discontinued - don't. Merck, which designed the drug has ceased production. However, generic labs still produce it very cheaply. They can't be sued for negligence because they didn't design the compound. | M | 68 | 12 years | 4/18/2009 | 5 | depression/anxiety/irritability | Visual trails occasionally in the AM (worse when mixed with a benzo or lack of sleep). Nausea when tapering up | I have been on and off a number of psychiatric meds for the past 12 years. I've never felt more balanced or regulated as I do now. The side effects are minimally obtrusive at best and completely worth the positive effect it has had on my mood. Among the ssris, benzos, and other meds I've tried (about 15 all together), Serzone has had the most drastic effect on my mood with such minor side effects. | M | 27 | 8 weeks | 2/28/2009 | 4 | Depression | Difficulty ejaculating. Inability to get words in mind out of mouth. Visual trails behind motion first thing in the morning. Adding Bethanacol to the mix helped with the abiltiy to get words out of mind to mouth, and a little bit with the ability to ejaculate. Ejaculation was possible but took longer than either party wanted. | This did an instant job of lifting me from very deep depression. I felt better the morning after I took it. I had some relapses in depression in the first few weeks but nothing major. It worked as advertised. | M | 40 | 2 years | 1/13/2009 | 5 | Bipolar Disorder | When starting medication experienced headaches for just a couple of days. If I miss multiple days of meds, get headache when starting back. No other side effects. | I have been taking serzone for 18 years with just a 1 year lapse as other antidepresents were tried. Doctor has tried many other medications for me and there is some disinct properties of the medication which allows it to work best for me. This is the ONLY antidepresent that has been effective for me. I too worry that it will be taken off the market. Doctor indicates there is no equivelant meds. | F | 45 | 18 years | 1/7/2009 | 2 | GAD and sexual side effects | None. I had no side effects, but no effects | I was taking in addition to 5 mg Lexapro to try to assist with mood enhancing, anxiety, and most of all, to decrease sexual side effects associated with SSRI use. It did not work. Did not cause any side effects, but was not effective at all. Went all the way up to 400mg daily, but still nothing | F | 32 | 4 months | 11/1/2008 | 4 | Generalized anxiety | Slight sexual dysfunction - I can get erect but have a tough time ejaculating few about 10 or so hours after I take it (200 mg 3 times daily). I am able to ejaculate if I skip a dose, which I find acceptable given the anxiety relief I get (and that is better than the other SSSI/Tri's drugs I took). | I tried many other SSSI/Tri's - Prozac, Wellbutrin, Paxil, Tofrinal, and others I don't even remember its been so long since I've been on this one. I have been very satisfied with Serzone. I often worry it will be pulled from the market. Paxil worked ok, but had higher sexual dysfunction for me, which research supports. I no longer get panic attacks at all - many many many years. I still get some generalized anxiety, but it is quite manageable. My doctor sometimes suggests I get off this and try something new (now Cymbalta, a few years ago Remeron). But I just recall how difficult it is to move from one drug to another, with the potential side/withdrawal effects and have no desire given Serzone is working well. This is no way I can function without out - I would have severe anxiety if not panic and this removes it. Results shows that while some individuals have experienced liver failure, that likelihoods very small, say 1 in 10,000. I'll take those odds, given the challenges a | M | 38 | 9 years | 10/26/2008 | 1 | Anxiety, Depression. | extreme nausea, vomiting, auditory and visual hallucinations, uncontrolled movements, severe head ache, terrible anxiety/paranoia, very tingly feeling all over body, insomnia. | My "doctor" told me that he hadn't prescribed this drug in six years. Obviously not using his logic, he went ahead and prescribed it. I took it at 7:00 Wednesday night, it's now Thursday at 5:00, and I feel effing terrible. Read what other people have posted, I guarantee it's not an exaggeration. Adverse effects are very very severe. I took it at 300 mg. It's comparable to having serotonin syndrome--it sucks, but it better be temporary | M | 21 | 1 days | 9/25/2008 | 4 | Anxiety, Depression | Some lightheadedness. Difficulty waking up. Calm, unmotivated feeling. Headaches during the first week. | Serzone (Nefazodone) was prescribed by my psychiatrist as an adjunct to 20 mg daily Prozac. The Prozac had made sleep difficult and took away my libido. My Serzone dosage is 100 mg, twice daily. I can say that the Nefazodone has helped a lot. I'm much less anxious than I was before. Now I sleep much better, too. Libido has improved quite a bit (my wife would agree with that statement). The downside is that getting up in the morning can be difficult. I'll often feel a bit sleepy and unmotivated. This is a tradeoff I'm willing to make. Lastly, I have my liver enzymes monitored every 3 months. | M | 38 | 10 months | 8/21/2008 | 5 | anxiety depression anger bipolar | None. I was taking zoloft and had lots of side effects with that - runs no sex drive etc. I switched and stopped getting them. I do have a slight but very bearable headache - I just satrted Chantix to quit smoking though and think it is from that. | I take serxone as a combination with 150mg of Lamictal. I started about 9 months ago. I can not tell you what wonders these two medications have done for me. I am not a new person or clouded or sleepy or anything - I am me. And I am happy!!!! Happier than I ever thought possible, I am still me though I dont laugh everything off but I am no longer extreme and I my anxiety is gone! I wish I had gotten help sooner - I just never believed in taking medication. Family and friends saw the changes and I finally admitted to taking these meds. they too were shocked and so happy it made me healthy again! | F | 33 | 8 months | 8/15/2008 | 2 | bipolar/anxiety | Took at bedtime, went to sleep, woke up with MAJOR anxiety, panic attack, saw giant pink spiders (spider phobia) crawling up my walls, crying uncontrollably, shaking and rocking | I took this for a very short time, VERY...Now I list it as one that I'm allergic too. | F | 28 | | 6/26/2008 | 5 | Anxiety / Depression | Feel sleepy which is good since I take it at night. | This drug has worked wonders for me. It restores my REM sleep and I don't have any sexual side effects. I highly recommend it. | M | 34 | 8 weeks | 6/25/2008 | 3 | --- | --- | hi, if anyone has spare serzone and wants to sell them off, please sell them to me. my email address is brendaschultz2002@yahoo.com I WILL BUY YOUR UN-USED SERZONE / GENERIC NEFAZODONE FROM YOU. | M | 88 | 0 days | 6/23/2008 | 4 | Anxiety, depression | My dose is currently about 125 mg at night. Blurred Vision: I'm 56 have had to use reading glasses since I was 46, but with this drug, my far sightedness, which used to be excellent, is blurry now. Mornings, I'm sort of foggy and confused. I feel clearer in a few hours. I've lost 10 pounds, but that's probably because I'm also tapering off from Paxil, which has to go very, very slowly, due to the withdrawal symptoms. | On the plus side, unexpectedly, my sex drive is coming back! It's been away since about 1990, when I started taking SSRI's. My mood is good and there is no rumination. Getting to sleep is easy but staying asleep for more 3-4 hours is not possible. Then I take about 1/8 of an Ambien, which works for me. Anti-depressants that have worked for me in the past are Prozac, Celexa and Lexapro; although I've tried many others. | F | 56 | 2 months | 5/29/2008 | 1 | Anxiety | Worst headache ever! | I never get Headaches. But after my first dose of Serzone I got the worst pounding migraine headache ever. I was literally on my bed in a ball crying. It's the worst drug I've ever taken! I stopped taking Serzone immediately. | M | 39 | 1 days | 4/5/2008 | 1 | depression | My first symptoms were plugged ears which later changed to tinnitus which lasted for 5 years after I discontinued the drug. I took this drug for 2 years and spent the 2nd year trying to get off of it. Serzone is difficult to stop taking as it causes muscle pain with withdrawal. Seven years later, I have no lasting side effects. | You should wean off this drug very slowly. | F | 49 | 2 years | 2/21/2008 | 1 | depression | This drug was removed from the market in Canada because it causes liver failure. I know someone who died from ingesting this drug. Acupuncture is an incredibly effective treatment for depression without the associated severe risks of antidepressants, and has the added benefit of improving one's overall appearance. And acupuncture works after the first treatment. | F | 29 | 3 months | 2/17/2008 | 1 | treatment-resistant depression | grogginess, blurred vision, delayed reaction time, general fatigue, worsening depression, self-harm urges | For two weeks (during which I had a particularly nasty illness), I took 50 mg each morning and evening. For the next month, I took 100 mg each morning and evening. At this point, I was experiencing few to no side effects, and no discernible intended effects. After about a month of this, (on January 12th) I was directed to increase the dose to 100 mg each morning and 200 mg each evening, and all hell broke loose. For the last two weeks, I was experiencing a lot of the side effects that I remember from trazodone (grogginess, blurred vision, delayed reaction time, general fatigue), along with an extreme worsening of my depression, including feelings of uselessness and urges to hurt myself. | F | 27 | 2 months | 1/22/2008 | 3 | Depression and Anxiety | I was on a dose of 600 milligrams for a while and became more depressed and anxious than ever. I switched doctors and the new doctor dropped me down to 450 milligrams. That worked fine for a long time and I didn't really have any side effects except for occasional anxiety and depression. I started cognitive therapy and over the course of two years tapered completely off the Serzone. I have felt fine in the two months that I have been off it. I have one month prescription handy just in case. I would consider taking it again if necessary. | F | 53 | 7 years | 12/5/2007 | 5 | bipolar, anxiety, depression | No side effects compared to the other antidepressants I have taken. | I have tried Zoloft, Paxil, Cymbalta I have also tried seraquol and abilify. And none of them worked. Or they gave me such bad side effects that I was hospitalized. I am currently on 1800 mg of Neurontin, 600 mg seazone, and 300 mg wellbutrin and I have never felt better. No fogginess, no sexual dysfunction, no panic. | F | 39 | 8 years | 11/28/2007 | 2 | depression, anxiety, dissociation | Weird visual "trails" when I was really tired, or when I didn't get enough sleep, or when I was particularly anxious. Mostly this was when I coupled the med with a benzo for anxiety, though it could sometimes cause the visual disturbances on its own. They were really scary until I figured them out. I stopped taking the medication because I worried about what it was doing to my liver. | Can cause serious liver problems. Isn't even approved in many countries. I had my liver functions tested often, and eventually decided to go off of this because of the liver dangers. My psychiatrist disagreed with me, but the risk wasn't worth it to me. | F | 30 | 1.5 years | 10/13/2007 | 4 | Bipolar Depression | Drowsiness, nausea | Helped greatly with anxiety which accompanied my BP II depression, allowed me to function at a better level for many years. It did not help the depression so much, but it did not cause sexual side effects like most other medicenes, so that was a huge plus. It became unavailable to me in April of 2005 so I quiut using it and have not been able to find a replacement. When I found a generic Nefazodone, it did not seem to work again and became severely drowsy to the point of making it not feasible to take the drug anymore. | M | 30 | 9 years | 10/10/2007 | 4 | severe depression | Took it only a couple of weeks because I became concerned about the possibility of liver problems. During that time, though, I slept well and felt less anxious. If I took a klonopin at betime also, though, the next day I would be ravenous and could not stop thinking of food. Dr. warned me that Nefadezone would enhance klonopin's effects and I should reduce it. Other anti- depressants have not worked for me, but I am not willing to rish liver failure and some of the other problems I have read about even if they are rare. | F | 54 | 14 days | 8/7/2007 | 1 | Depression and anxiety | Weight loss, insomnia, dizziness in head 30 mins after taking dosage each morning. | This was the least effective of the anti-depressants I have been on. I stuck with it for awhile because it did not affect my libido. However, I did not realise at first it was keeping me awake at night which in effect made it difficult to focus. during the day I also lost too much weight on it. Friends thought I looked gaunt and unwell. I also picked up every cold or flu that was going around while being on this. It is no longer available in Australia. I felt that it only marginally lifted my depression. AVOID ANJD LOOK FOR SOMETHING ELSE | M | 40 | 2 years | 7/6/2007 | 5 | depression | I took Serzone for several years and now take Nefazodone. I have had great results with it, libido back, weight loss, sleep well. I make sure to take it after eating as it caused nausea on an empty stomach. I currently take 200 mg. after breakfast and 200 mg. before bed with no food as I get no nausea then. I have experienced loose stools since taking these drugs and now have early morning diarrhea (starts at 6:00 a.m.) 2-3 times - quite severe. This has gotten worse over the past six months or so and causes me to feel rather "wiped-out" for a while in the morning. Are other people experiencing this after long-time use of Nefazodone? I previously took Paxil and experienced weight gain after a while and sexual disfunction all the time. | The grading of 5 does not reflect my intestinal problems. | F | 63 | 5 years | 6/14/2007 | 5 | major depressive and panic attacks | My side effects were sleepiness and nausea at night but the side effects were well worth it to me. | I too had tried everything on the market and nothing worked like serzone. for the first time in my life i stopped feeling suicidal and I stopped crying every day. My panic attacks went away until recently. I have to transition to another med becuase I have plateau at this med. I am now transitioning onto trazadone and so far its working well not as good as the nefazadone but better than alot of the other stuff I've tried. I was devastated to find out it wasn't covering me anymore, for the last twelve years, it has been a God send for me. Sorry others had a bad experience with it, it just goes to show how chemically different we all are. | F | 31 | 12 years | 4/14/2007 |