ANAFRANIL Reviews (CLOMIPRAMINE HYDROCHLORIDE)

Average Rating: 3.7 (133 Ratings)

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 ANTIDEPRESSANTS CNS, MISCELLANEOUS

 Type: Rx Drug

  

ANAFRANIL  (CLOMIPRAMINE HYDROCHLORIDE):  Clomipramine is used to treat obsessive compulsive disorder (OCD). It helps decrease persistent/unwanted thoughts (obsessions), and it helps reduce the urge to perform repeated tasks (compulsions such as hand-washing, counting, checking) that interfere with daily living. This medication belongs to a class of medications called tricyclic antidepressants. It works by restoring the balance of certain natural substances (serotonin, among others) in the brain.   FDA Approval Date: 1989-12-29 (Sources: U.S. Centers for Medicare Services, FDA)

  

Results are sorted by length of time drug was taken longest to shortest.

Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on ANAFRANIL: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR ANAFRANILCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 5  OCD and anxiety Flushing They changed my life enabling me to live with OCD pure O I dread to think how I would have managed without them. F 62 40 years
25 MG 1X day
11/21/2020
 5  Anxiety, major depression, OCD Constipation, Short term memory loss, hand tremor, weight gain... all minor but much better than not taking the medicine. My Doctor quickly upped the dosage higher and higher. Over 150 mg at one point. I cut it down to 25 mg and kept it that was for many years. Now I have reduced it to 10 mg. Doctors like to increase the dosage but I feel fine now at 10 mg. My Doctor is aware that I cut it back. Anafranil is an old drug but was brand new when I first started. I tried the newer drugs but they don't work for me. Zoloft was terrible. I also tried Citalopram, Wellbutrin and others but for me I seem to do best with Anafranil. What works for one person won't always work for another. Anafranil is a miracle drug for me. M 49 32 years
10 1X day
12/22/2017
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 4  Sexual disorder Very bad constipation F 63 30 years
25mg 1X day
10/13/2014
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 5  suicidal depression, anxiety, OCD 25 years experience. Works very well but side effects keep me trying other meds. Yet always a relief to get back to clomipramine (anafranil). Anticholinergic effects include acid reflux leading to scarring of esophagus and inability to swallow many foods without simultaneously drinking lots of warm/hot water, necessitating so far 2 outpatient operations to stretch esophagus. No sexual dysfunction for first 12 years but now severe (depending on dosage, as is libido loss) as I age. Reflux plus dry mouth anticholinergic effect have caused bad tooth decay. Bloating and weight gain. Mental confusion and difficulty urinating on higher doses, i.e., over 100 mg daily sometimes, but at other times fine on 165mg. Constipation, sweating, trembling, imbalance were mainly issues in the earlier years during which I often experienced some borderline serotonin syndrome. Saved my life for sure. I was hospitalized, so they could go straight to 150 mg, and by the 4th day I felt great. Maintains a real sense of well-being. Still have intrusive obsessional thoughts at times, but now I'm almost detached from them and they pass quickly. I keep trying to lower the dose because of side effects, and success depends upon changing life circumstances, seasons and how much anti-anxiety meds I am prescribed. Tricky, but I've done this often enough I don't have to wait to feel suicidal anymore to know I need to increase my dose. I've been on as little as 40 mg daily for 2 months and as much as 200 mg daily when things aren't going well, soon tapering to 150 due to borderline serotonin syndrome. A dose increase like this after falling into depression is like being plucked out of hell into a state of grace, no exaggeration. My average daily dose is 75-90 mg. Also really helps against anxiety and insomnia. Higher doses are the best painkiller ever for my bad back. My generic is APO. Once I filled my Rx at a different pharmacy and sunk into a severe depression. I hadn't noticed the generic was GEN. My shrink said that generic had that reputation. Why don't these dummies tell you these things beforehand? I've also never had a doc tell me about tooth decay from dry-mouth-causing drugs. Drinking water, etc. isn't enough. Dental hygienist says you need a salivary enzyme replacement toothpaste and/or mouthwash, e.g., Biotene. M 62 25 years
3/13/2009
 5  OCD Loss of interest in sex, inorgasmia, impotence Lifesaver for keeping OCD at bay, also stops my insomnia and allows me to wake up at a normal time without feeling groggy all day which I cannot do otherwise. Great feeling of being at peace. M 31 15 years
100mg 1X day
12/27/2013
 5  OCD Dry mouth, weight gain, excessive sweating (head), harder to orgasm I was diagnosed with OCD at 13 - hand washing, checking, intrusive thoughts. This drug made my OCD completely disappear. Yes the side effects are not great, but they are not the end of the world. When I had OCD I could not function normally at all, all my time was taken up with my obsessions, I can function normally with these side effects. I have tried coming off the drug many times in the last 13 years but when I do, I get very emotional and depressed and my intrusive thoughts come back. I would recommend this drug to anyone with OCD, the dull headaches and tiredness do go with time, just keep taking it regularly and they will disappear. The side effects I have sited above, however do not seem to disappear. F 26 13 years
75mg 1X day
6/25/2011
 5  OCD Difficulty getting to an orgasm. It has helped the OCD to a great deal. I've tried replacing it with Prozac, it didn't work at all. I switched back to Chlomipramine (Anafranil) again. 12 years
6/26/2007
 5  OCD, Depression Dry mouth, constipation F 60 10 years
100mg ?
3/6/2012
 5  FOR ANXIETY WITH OBSESSIVE THOUGHS DRY MOUTH,CONSTIPATION,HEART BURN I HAVE TRIED MANY OTHER ANTIDEPRESSANTS AND HAVE NOT HAD SUCCESS WITH THEM LIKE ANAFRANIL.I AM ABLE TO WORK AND HAVE A NORMAL LIFE. I HAVE STRUGGLED WITH THIS DISEASE ON AND OFF SINCE I WAS TWENTY ONE. F 43 10 years
12/19/2009
 4  Panic disorder Sweating, weight gain, loss of libido Works incredibly well for panic disorder but weight gain and loss of libido are severe. M 53 10 years
75mg 1X day
8/24/2020
 4  OCD,panic,GAD,Mjr depresion,moods dry mouth, spaced out, decreased sex drive. Feeling sleepy and zombified. Fatigued, numb, frequent UTIs, constipation, tremors, feeling of not being myself. Have tried just about every other medication and nothing helped. This actually works. Sometimes i find the side effects are a bit too much to deal with but would rather have them than my original problems. Don't know what i would have done without anafranil. It saved my life. F 30 10 years
2/3/2009
 3  ocd constipation , bloating,muscle pains,breast enlargment,diffuculy urination,fatigue and in high doses dry mouth and excessive sweating to me it doesnt work in high doses and made ocd symptoms more severe be careful with the dose very low doses may benifit you and higher make ocd severe.talk with your doctor.i used to take it in 150 mg but after many years i take fluoxetine and low doses of anafranil. M 30 10 years
18,75 mg 1X day
7/20/2012
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 5  anxiety, depression, OCB, phobias constipation, non existent sex drive, sleepiness, memory loss problems, weight gain. Have tried so many other medications that didn't help at all and anafranil has taken away all mental issues. Was on 125mg and now on 50. Benefits far outweigh side affects!!!! F 27 6 years
5/15/2006
 5  for obsessive compulsive disorder on high doses, twitching; now on a low dose and have no side effects; I have gone on to live a completely normal life almost completely symptom free of OCD. F 42 5 years
7/6/2007
 5  OCD, depression, fibromyalgia At first many such as anorgasmia and weight gain and sweating profusely but these have to be lived with sometimes for weeks because it is such an old medication. The good news is that with time these subside and adding 30 min of cardio 4 times per week can really help with the weight as well as the depression. Old medicines sometimes work better than newer ones M 37 5 years
225 mg 1X day
9/6/2010
 5  depression weight gain, sleepiness It changed my life, now I´m a happy person again. It is the best medicine by far. M 31 5 years
1/4/2010
 4  Severe pure ocd and anxiety Severe Weight Gain Acid Reflux Saved my life but came off it because of weight gain but started on it back again. F 34 5 years
150 mg
3/18/2015
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 4  OCD Constipation, lower sex drive. Made my life better M 29 5 years
2/25/2005
 1  OCD Anxiety, dry mouth, constipation, zombie-like, emotionally numb, personality changes, suicidal, cutting I was introduced to anafranil in 1990 by Dr. Jenike at the OCD Clinic at Mass General Hospital. I had a history of panic disorder from the time I was 10 and it manifested into OCD when I was 25. Approximately 5 hours after taking my very first dose which was probably 50 MG, I went into one of the worst anxiety attacks of my life and had to be taken to the hospital. Anyone with pre-existing anxiety disorder should be aware that anti-depressants can trigger extreme panic attacks! Be sure to take your xanax or klonpin when taking anafranil. After 4 years (not consecutive as I became pregnant and stopped all meds during that 9 months), I couldn't bear not having the desire to play my musical instruments or do art any more. I felt like a zombie most of the time. Looking back, there is so much that I cannot remember from 1990 - 1995. I do recall cutting myself (the scars are still there on the back of my arm) and threatening suicide in front of my parents. Anafranil may have stopped me from doing a lot of the obsessive rituals, but it also ruined my kids' and my life. I was introduced to zoloft in 1995 and that actually worked amazingly well for the OCD without all the horrible side effects of anafranil. I've been med-free and I'd say about 95% OCD-free since 2004. F 45 5 years
100 MG 1X day
6/26/2010
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 5  Panic disorder (Severe) Dry mouth, blurred vision, constipation and of course very reduced sex drive This stuff works so much better than anything I have ever been on and I have tried most. Removes completely panic symptoms and greatly reduces anticipatory anxiety - fantastic med if only it didn't kill your libido. I am currently trying different meds, SSRI's - no good for me now on Moclobemide and sex drive back but so is panic! Will be going back on Anafranil ASAP. M 4 years
7/30/2006
  

ANAFRANIL  (CLOMIPRAMINE HYDROCHLORIDE):  Clomipramine is used to treat obsessive compulsive disorder (OCD). It helps decrease persistent/unwanted thoughts (obsessions), and it helps reduce the urge to perform repeated tasks (compulsions such as hand-washing, counting, checking) that interfere with daily living. This medication belongs to a class of medications called tricyclic antidepressants. It works by restoring the balance of certain natural substances (serotonin, among others) in the brain.   FDA Approval Date: 1989-12-29 (Sources: U.S. Centers for Medicare Services, FDA)

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