ANAFRANIL Reviews (CLOMIPRAMINE HYDROCHLORIDE)

Average Rating: 3.7 (133 Ratings)

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 ANTIDEPRESSANTS CNS, MISCELLANEOUS

 Type: Rx Drug

  

ANAFRANIL  (CLOMIPRAMINE HYDROCHLORIDE):  Clomipramine is used to treat obsessive compulsive disorder (OCD). It helps decrease persistent/unwanted thoughts (obsessions), and it helps reduce the urge to perform repeated tasks (compulsions such as hand-washing, counting, checking) that interfere with daily living. This medication belongs to a class of medications called tricyclic antidepressants. It works by restoring the balance of certain natural substances (serotonin, among others) in the brain.   FDA Approval Date: 1989-12-29 (Sources: U.S. Centers for Medicare Services, FDA)

  

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5=HIGH (this medicine cured me or helped me a great deal.)

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More on ANAFRANIL: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR ANAFRANILCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 3  Anxiety Blood pressure fluctuation 70 3 days
25
4/7/2020
Email
 5  depression anxiety panic slight constipation seems only one helps very well with my mental problems M 68 2 years
10 mg 1X day
1/7/2023
Email
 1  anxiety and depression Shaky worse anxiety sick feeling crying all the time no relief. Dear God I need some relief from this medicine if my Dr. will not take me off I going to take my self off couldn't feel any worst from withdrawal. I took this back in 1990's the Generic doesn't come close to the original. This is working in reverse of what it did at that time. Thanks drug companies always looking for ways to make money and don't really care about the patients. If you did you make it affordable and make back to the original. F 64 35 days
100 1X day
12/7/2015
Email
 4  Sexual disorder Very bad constipation F 63 30 years
25mg 1X day
10/13/2014
Email
 2  Anxiety, OCD, Panic Attacks Terrible nausea, zero energy, and extremely sleepy, Zombie-Like state, very dry mouth. I have tried to go on this drug twice without success due to the bad side effects. I was only on it twice for 2 days each but could not handle the horrible feelings. May work for some but not for me. I even had to special order this drug since it is not readily available at most pharmacies. M 63 4 days
8/6/2009
 5  suicidal depression, anxiety, OCD 25 years experience. Works very well but side effects keep me trying other meds. Yet always a relief to get back to clomipramine (anafranil). Anticholinergic effects include acid reflux leading to scarring of esophagus and inability to swallow many foods without simultaneously drinking lots of warm/hot water, necessitating so far 2 outpatient operations to stretch esophagus. No sexual dysfunction for first 12 years but now severe (depending on dosage, as is libido loss) as I age. Reflux plus dry mouth anticholinergic effect have caused bad tooth decay. Bloating and weight gain. Mental confusion and difficulty urinating on higher doses, i.e., over 100 mg daily sometimes, but at other times fine on 165mg. Constipation, sweating, trembling, imbalance were mainly issues in the earlier years during which I often experienced some borderline serotonin syndrome. Saved my life for sure. I was hospitalized, so they could go straight to 150 mg, and by the 4th day I felt great. Maintains a real sense of well-being. Still have intrusive obsessional thoughts at times, but now I'm almost detached from them and they pass quickly. I keep trying to lower the dose because of side effects, and success depends upon changing life circumstances, seasons and how much anti-anxiety meds I am prescribed. Tricky, but I've done this often enough I don't have to wait to feel suicidal anymore to know I need to increase my dose. I've been on as little as 40 mg daily for 2 months and as much as 200 mg daily when things aren't going well, soon tapering to 150 due to borderline serotonin syndrome. A dose increase like this after falling into depression is like being plucked out of hell into a state of grace, no exaggeration. My average daily dose is 75-90 mg. Also really helps against anxiety and insomnia. Higher doses are the best painkiller ever for my bad back. My generic is APO. Once I filled my Rx at a different pharmacy and sunk into a severe depression. I hadn't noticed the generic was GEN. My shrink said that generic had that reputation. Why don't these dummies tell you these things beforehand? I've also never had a doc tell me about tooth decay from dry-mouth-causing drugs. Drinking water, etc. isn't enough. Dental hygienist says you need a salivary enzyme replacement toothpaste and/or mouthwash, e.g., Biotene. M 62 25 years
3/13/2009
 5  OCD and anxiety Flushing They changed my life enabling me to live with OCD pure O I dread to think how I would have managed without them. F 62 40 years
25 MG 1X day
11/21/2020
 5  OCD, Depression Dry mouth, constipation F 60 10 years
100mg ?
3/6/2012
 5  OCD Surprisingly few. A little dry mouth, but only for short periods of time I have tried all SSRIs other than Celexa. They just didn't cut it. Prozac worked well until poop out after 17 yrs. Anafranil was different (better). With my first dose I could tell the difference. Calming. Now up to 150 mgs and loving it. Don't hesitate if you have stubborn OCD. M 58 5 weeks
11/26/2008
Email
 3  depression Felt absolutely wonderful. Gained 28 pounds in 4 months and for this reason had to stop medication F 58 4 months
2/24/2005
 2  Ocd Terrible heartburn, brain fog and nausea. Rather live with Ocd than take anymore of this evil medication 58 4 weeks
25 1X day
1/8/2022
Email
 5  OCD/depression constipation, weird dreams, difficulty losing weight I rather be overweight and happy than thin and miserable. Really helped with both depression and obsessive thoughts, F 56 2 years
9/24/2009
 5  Depression/Anxiety Sweating, weight gain (about 20 lbs) other than that none really. I have tried all SSRI's and this so far is the best. I take 100-150 mg per day. I was surprised because alot of the pharmacies don't even carry it anymore. Helped my anxiety, obsessive thoughts, which in turn eased my depression. I would highly recommend it. F 55 7 months
6/10/2009
 5  ocd anxiety dry mouth sweating not sure if the rest was me or the drug M 54 27 days
2/18/2009
Email
 5  OCD anxiety depression Nil except a little drowsiness first couple of days I am stunned at how effective this is for me. I am taking it in conjunction with Quetiapine. I have taken many other antidepressants but nothing has touched the anxiety which feeds the OCD until I started this. In one week my stomach has completely unknotted, I am stable and happy and my compulsions are coming under control. I could not be more happy so far. F 54 7 days
75mg 1X day
9/15/2014
 5   M 53 1 days
10/19/2013
 4  Panic disorder Sweating, weight gain, loss of libido Works incredibly well for panic disorder but weight gain and loss of libido are severe. M 53 10 years
75mg 1X day
8/24/2020
 3  OCD it has helped but I have noticed an increase in low back pain and pain in the joints of my hands. The pain is worse in the mornings and as the day progresses improves. Other than that its good. F 53 1 years
25 1X day
2/3/2011
 5  anxiety panic bad constipation, sleepiness, hungry feeling, dry mouth, dizziness upon standing. Shut down the panic. But side effects and using Phillips all the time made me change. Took six weeks to finally tolerate the side effects to a limited degree M 52 3 years
75 1X day
8/18/2010
 1  Premature ejaculation ( v dangerous) I took anafranil I start shivering and feel nusea after 3 hours I got massive heart attack I fell down broke my jaw, I admitted in hospital for 5 day they put stents, I was about to die, please ban this medicine .Thank you Please don't sell this medicine. If any death occur management is responsible for that. M 51 4 days
10mg 1X day
10/7/2023
  

ANAFRANIL  (CLOMIPRAMINE HYDROCHLORIDE):  Clomipramine is used to treat obsessive compulsive disorder (OCD). It helps decrease persistent/unwanted thoughts (obsessions), and it helps reduce the urge to perform repeated tasks (compulsions such as hand-washing, counting, checking) that interfere with daily living. This medication belongs to a class of medications called tricyclic antidepressants. It works by restoring the balance of certain natural substances (serotonin, among others) in the brain.   FDA Approval Date: 1989-12-29 (Sources: U.S. Centers for Medicare Services, FDA)

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