PRILOSEC Reviews (OMEPRAZOLE)

Average Rating: 1.9 (1667 Ratings)

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 DISORDERS, ACID PEPTIC

 Type: Rx Drug

  

PRILOSEC  (OMEPRAZOLE):  Omeprazole is used to treat certain stomach and esophagus problems (such as acid reflux, ulcers). It works by decreasing the amount of acid your stomach makes. It relieves symptoms such as heartburn, difficulty swallowing, and persistent cough. This medication helps heal acid damage to the stomach and esophagus, helps prevent ulcers, and may help prevent cancer of the esophagus. Omeprazole belongs to a class of drugs known as proton pump inhibitors (PPIs).   FDA Approval Date: 1998-01-15 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on PRILOSEC: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR PRILOSECCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Duodenum ulcer I was taking omeprazole for 8 months for a duodenum ulcer.It was horrible. Everyone around me pressure me to keep taking it. And my Dr said I must be on it. I had constant anxiety, stomach pains, horrible sleep, complete loss of appetite. I was so afraid to quit because if the acid rebound and withdrawal symptoms. But about a month and a half ago I quit after reducing my dose. The first week was pure hell. Lucky to sleep 3 hours a night. Anxiety was threw the roof. The best part about it was I just had another endo and I still have the ulcer. I will never take this again. I changed my diet. I took 40mg for 3 months, 20mg for 2 months and 20mg every other day for 3 months M 43 8 months
40 1X day
12/18/2020
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 1  Reflux This medication is poison. I was prescribed it after gallbladder removal to help with morning reflux. I started to notice I was extremely anxious and depressed, could hardly function or work. My headaches were horrible and started having random muscle spasms. Never for one second thought something like this could have been the cause until I put 2 and 2 together, searching online and finding posts that were identical to my own experience. I've been off the medication now for 3 days and I feel miserable but I'm pushing through it because I will never take this again. Don't take it! F 32 35 days
20 MG 1X day
12/17/2020
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 1  Gerd Depression, anxiety, hot throat sinus infections, irritable everything bothered me. Doom and gloom, it seemed like my world was coming to an end.Constant coughing up phlegm kept me awake at nite. Do not take I think it's some kind of poison. F 75 3 months
20mg 1X day
12/15/2020
 1  Gerd Neck and back tightness tightness and pain in shoulders weakness brain fogVery severe anxiety panic attacks tremors M 68 7 days
20 MG 2X day
12/9/2020
 1  Acid Reflux Anxiety, insomnia, tinnitus, brain fog, etc. I took omeprazole for 14 days to treat my acid reflux and it was the worst decision EVER. I developed anxiety and insomnia out of nowhere! I can usually sleep easily with long sleeps but now my sleep is destroyed! Waking up every hour sweating, heart palpitations, tinnitus and anxiety. There were nights I only had 2-3 hrs of sleep or none at all. So decided to stop taking and im 21 days off of it. Still having side effects but way way way better than before. Please do not take this! Should have gone the natural way to treat acid reflux. M 37 21 days
20mg 1X day
12/2/2020
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 1  Acid reflux Severe depression, chronic fatigue, severe brain fog, frequent irritability/personality changes, anxiety/lower stress tolerance I started experiencing some acid reflux symptoms around 2017, when I was 24. They got more frequent & severe over the next year and my doctor put me on Prilosec two years ago when I was 25. Over time, I started developing pretty life-changing side effects (had it happened right away, I would have made the connection and stopped it, but given the slow, but steady, onset, my doctor's assurances that it was completely safe, & my age being in the range when mental issues often manifest in younger men, I thought it might have been a dozen other things): An almost unceasing (and worsening) brain fog, a sudden problem with anxiety (particularly in social situations or when speaking to groups), regular and worsening depression, chronic fatigue so bad that I often couldn't stay out of bed long enough to do work and would regularly lose days in a totally unproductive haze, and extreme irritability. I stopped taking this about a month ago and while the negative effects haven't yet vanished, they feel like they've stopped getting *worse*, so I hope it's a matter of time before I'm my old self again. TL;DR: I'm stunned that this garbage made it through FDA testing and wouldn't recommend it to anyone who doesn't want to feel like a complete trainwreck of a person. I would honestly rather have just stuck M 27 2 years
40 1X day
11/30/2020
 1  Acid reflux I feel completely sad, headaches, I have phlegm in my throat and cough with wheezing taking Atrovent for it to see what I have meanwhile I see a pulmonologist. X Ray are fine and blood exams fine. This drug has me depressed and I'm so hyper and pumped always. No sex drive whatsoever.... I'm very strong mentally... this isn't like me. When I take it I feel annoyed want to be left alone and not talk to anyone. I get annoyed by my husband poor guy. I feel like everyone is bothering me and I get sad bad thoughts. It's really horrible to be honest. They don't even know if my cough is in fact reflux Lol! I been with a 5 month cough from prednisone to albuterol, benzonate, doxycycline , zythromax , mucinex, home remedies, steam with anamu plants and steaming to bring out phlegm , honey tea lemon .. you name it this fought began after a cold in the middle of pandemic but it was negative covid. I even had an inspector come to my house see if it's mold idk! I'm the only one like this. Before this year I was perfect healthy never needed a doctor. I am a teacher I teach from home. I have a daughter my life is good ... no one knows why I'm coughing yet but this medication needs to go... it makes you feel worse. Forget it F 29 1 months
40 1X day
11/27/2020
Email
 5  Acid reflux No issues that I can tell. Really helps with my acid reflux. Will continue to take it. M 61 20 years
30 mg 1X day
11/25/2020
 1  Upper GI Bleed/ Ulcer Worst god damn drug. How do they even get this sh*t FDA approved. I was prescribed this after I had an upper GI bleed from an Ulcer. Literally from the day I took I started feeling dizzy.. Day 2, bouts of depression and crying, overwhelming anxiety and random pains in the stomach area. I couldn't sleep for the few nights I took this and when I could get an hour or so of sleep I would jolt myself awake. DO NOT TAKE THIS IF YOU CAN AT ALL AVOID IT. M 40 2 days
20mg 2X day
11/18/2020
 1  Reflux asthma severe depression, severe anxiety, panic, agitation, confusion, rapid thoughts, social nervousness, fatigue, feeling very cold, lump in throat, mild sore throat, increased stomach pain My asthma doctor prescribed this to see if it'd lessen my need for my rescue inhaler from attacks I get after eating and I wish I wouldn't have touched this stuff. I already have depression and social anxiety and adhd-type symptoms, but have been relatively stable lately and all that changed 2 days into taking this. Wasn't sure at first if it was the medication until I started googling reviews. I've been feeling like I'm losing my mind. I haven't noticed a significant improvement in my ‘reflux' since I never have heartburn, though I haven't reached for inhaler daily like I was before. It's definitely not worth it and I'll just stick with my inhaler. Glad I got on here and read through some of these reviews so now I know it's not just me. It's crazy that a medication like Prilosec can cause so much emotional trouble for someone in four-days' time. F 29 4 days
20 1X day
11/13/2020
 1  Possible ulcer/mild gastritis Night sweats, heart palpitations, insomina (woken out of sleep), rapid heart beat, bloating, restlessness, loss of appetite I went to the ER with extreme nausea systems, I had intermittent nausea for about four weeks prior, a bloddy stool(once), and dull burning upper abdomen pain for about six months. They put me on an EKG, X-rayed my chest, blood and urine, all normal. Then they pumped me with metoclopramide along with other antacid meditcations. I was on a prescription for omeprazole for two weeks until this past Tuesday. I haven't had a full night sleep since. When I laid down my heart would be pounding and if I tried to close my eyes I'd immediately be awaken with rapid heart beat and a feeling of an adernaline rush/fight or flight feeling. I've had higher resting rate rates since. I can't sleep for more than three hours on a good night some nights it's up every hour and a half. It's been 48 hours since I've taken my last dose and I've started to sleep more hours of the night but the sleep is still broken up. I had a three night span of a total of 5 hours sleep. Anyone with similar reactions to being on Omeprazole and how long it took you to get back to normal sleep. M 35 14 days
40-80 1X day
11/6/2020
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 1  acid abdominal pain M 68 56 days
2X day
11/4/2020
 1  silent reflux pins and needles, twinges, twitches, burning feelings in hands, arms, legs, feet, sensitivity to cold, tense/ tight muscles, brief occasional stabbing pain, pricking/ prickly feelings One day, 2 weeks ago I started having pins in needles in my hands, arms, legs, feet. By the end of the day I was worried. Checked my medications and saw that Prilosec can cause pins and needles. So I stopped Prilosec the next day. Pins and needles abated a little, but soon new symptoms appeared in addition - burning feelings in legs, feet, arms and legs, twinges primarily in my legs, muscle tightness in my upper arms and legs, sensitivity to cold in my hands and feet, very very slight tremors in my hands, occasional brief stabbing pain in ankle waking me from sleep/ strong pricking feelings. Feelings of muscle weakness but I don't think I've actually had any muscle weakness. Everyday is different. Worsens at night when lying down. Had bloodwork done to check for vitamin and mineral deficiencies and all blood work came back normal. My ENT and PCP had not heard of these symptoms of Prilosec withdrawal but my neurologist had. Thankfully! He asid that Prilosec can cause an "inhibition of vitamin B12 absorption" and can cause "sensory symptoms." He said that even if the bloodwork doesn't show a vitamin B12 or B1 deficiency, my body can still be having a hard time absorbing it bc of the Prilosec. He is having me take vitamin B complex (vitamin B12 and B1 were the ones he specifically mentioned) for the next 3 months and expects me to have a gradually improvement during that time. He also evaluated my balance etc and since that was all fine, he said my sympto F 41 4 months
40mg 1X day
11/3/2020
 1  Acid reflux First time anxiety - feeling the end of me Helped my acid reflux at higher cost M 40 1 days
20 1X day
10/30/2020
Email
 1  Acid reflux Tremors, SEVERE anxiety, sore throat, dizziness, fatigue, numb hands and face, bad stomach cramps, back aches. M 27 6 days
20mg 1X day
10/29/2020
 2  Stomach and throat ulcers, gerd Unable to focus, slow memory recall, depression, feeling low, hopeless crying, anxiety, panic attacks, bad circulation in arms, tiredness, insomnia. Feeling of doom. Gas. After about 2 months. And upper endoscopy it had almost completely healed my ulcers. Thats nice but have been off a few days and dont feel better yet. Im kinda scared i wont get back to normal. F 36 2 months
40-80 mg 2X day
10/25/2020
Email
 1  GERD Extreme leg, Ankle pain. Started on day four in the middle of the night. Took one more dose and decided to stop. I'll never take this drug again. It's been 36 hours since I stopped still have the leg pains hoping this resolves quickly F 66 6 days
20mg 1X day
10/23/2020
 1  GERD Extreme aching both legs, ankle pain, hamstring tightening My symptoms started on day 4 in the middle of the night. Took one more dose and decided no more! It's now 36 hrs since my last dose . Legs feel miserable still. I hope it resolved quickly. I'll never take it again. Scary stuff. F 66 6 days
20mg 1X day
10/23/2020
 1  GERD Extreme aching both legs, ankle pain, hamstring tightening My symptoms started on day 4 in the middle of the night. Took one more dose and decided no more! It's now 36 hrs since my last dose . Legs feel miserable still. I hope it resolved quickly. I'll never take it again. Scary stuff. F 66 6 days
20mg 1X day
10/23/2020
 1  Stomach pain UPDATE: I have posted on here before several months ago suffering from all of the same nasty side effects as everyone else. After nearly 6 months of dealing with these issues, I have learned the following: The initial wave of side effects does subside after several weeks however some (chest pain, brain fog, heart palpitations, and lightheadedness) persisted. Every numerous tests/doctors, I finally found a doctor who listened to my complaints and put me on an elimination diet. Turns out I have now developed a corn and soy intolerance. I'm convinced it is from the Prilosec destroying my gut bacteria. Anyway, now that I have eliminated both (not easy in today's processed food society), I feel like my old self. Those still suffering, talk to your doctors or do your own research and look into food allergy/intolerances. M 33 14 days
20 mg 2X day
10/20/2020

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