PROMETRIUM Reviews (PROGESTERONE)

Average Rating: 3.1 (568 Ratings)

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 ESTROGENS PROGESTINS

 Type: Rx Drug

  

PROMETRIUM  (PROGESTERONE):  Progesterone is a type of female hormone (progestin). This medication is similar to the progesterone that your body naturally makes and is given to replace the hormone when your body is not making enough of it. In women who are not pregnant and not going through menopause, this medication is used to restore normal menstrual periods that have stopped for several months (amenorrhea). Progesterone is also used as part of combination hormone replacement therapy with estrogens to reduce menopause symptoms (e.g., hot flashes). Progesterone is added to estrogen replacement therapy to reduce the risk of cancer of the uterus. This medication is not for use in children. Progesterone must not be used to test for pregnancy.   FDA Approval Date: 1999-10-15 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on PROMETRIUM: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR PROMETRIUMCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 5  perimenopause No side effects. I take the generic. F 39 3 months
100mg nigh
7/16/2015
 5  Estrogen Dominance, PMDD 1st & 2nd day dizziness, increased ability to fall asleep(take night) Very calming, helped quickly during the day with irritability & pmdd symptoms. I have searched for interventions for PMDD. I found that I had very similar symptoms to estrogen dominance day 12-28. It was as if my pms started way early and my period took forever to relieve it. I would be extremely hungry, angry,anxious,short with everyone, gain weight, extreme fatigue. I even thought I was Bipolar. Nope...it's balancing that good ol estrogen. Prometrium isn't able to lower current estrogen but cam help balance and that's the key. My husband and I agree it's already changed my life. F 30 2 weeks
200mg
5/5/2015
Email
 1  to reestablish menstrual cycle Fatigue, dizziness, feeling as if I'm drunk Feeling lasts well beyond stopping the drugs F 30 7 days
400 mg
4/10/2015
 4  PMS/heavy period/estrogen dominance -helps me fall asleep fast -morning wake up very groggy -during day sometimes feel very tired -minor cramping/tenderness in the uterus area at first, since subsided I take 25mg on days 6-14, then 50mg days 15 to start of period before bedtime. I feel like I sleep deeper but then I wake up around 5am for some reason, I normally can sleep through the night. Sometimes I do feel very tired during the day, but I think this happens when I increase to 50mg and take my dose too late the night before. No breast tenderness, I have found it actually has helped my breast pain just before my period. I started taking Prometrium just before my last period, so I'm waiting for my next period to see if any changes w/ my flow, PMS, etc. But overall, I feel good on it so far. Just notice more fatigue when I increase to 50mg and if I take it too late at night. I'm going to try to take it earlier at night, maybe around 9pm. M 35 1 months
25mg 1X day
2/27/2015
 1  insomnia Stroke like symptoms: unable to focus, unable to walk. Also expereinced painful breasts, pain on right leg, dizziness, heart palpitations, anxiety. Warning--take upmost caution and do all research before considering this drug. This was recommended to me by a Naturopath Doctor. I made the mistake of not researching this drug before I took it, and so thankful I did not start on a higher dose. I question that this drug is even on the market, as in my opinion it should not be. F 57 14 days
100 mg 1X day
9/25/2014
 5  Menopause Less muscle pain, brain fog, and improved fine motor skills / cognative function; some abdominal weight gain, other weight gain (which I can live with since the pain and fine motor skills / cognative function have improved). I already take something to sleep (trazadone) so, it really hasn't affected my sleep. Vivelle dot .50 mgs 2 X a week didn't help me very much by itself; doctor added Prometrium (100 mgs); no joy. Per "The Estrogen Alternative: Natural Hormone Therapy with Botanical Progesterone" [Raquel Martin], Progesterone ratio needs to be 125% to 1% for estrogen to be effective. Applied Prometrium topically 2 X and rotated location to areas of skin that is thin (forearm, wrist, tops of hands, back of knees). Also, now I just "forget" to use it; naturally cycle myself off. Interval between mood going to &^$# is getting longer and intensity of mood swings are less. Other things to also consider (as previously mentioned) is bio-identical thyroid medication (like Armour); and adrenal support (like Relora) and cortisol precursors like 7-keto DHEA and Pregnenolone. Yes, I have gained weight, but, was not active nor eating a "clean diet" (craved carbs - sure sign of weak adrenals); sodium / potassium not balanced? Water retention less severe since eating 2 blended potassium rich meals every day (lots of resources for blended meals on web). And exercise has helped with burning fat. (It takes a lot more energy to burn fat after menopause -- see "THE COMPLETE FIT or FAT" by Covert Bailey (great section of menopause) or one of "Zone" exercise books / websites. You are NOT exercising as efficiently as you think you are because some exercises are not effective for burning fat as you might think! F 55 180 days
100 2X day
10/22/2013
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 4  night sweats/peri-menopause Drowsiness, mild stomach cramps, lethargy, somewhat depressed, mild headaches. Had a period (I was told by my doctor that I shouldn't but it was at the beginning therefore waiting a while before worrying too much about this) I am hoping the drowsiness goes away as I am finding it hard to function. Unfortunately for me I had just started a new position and my head is in the fog. When I first began taking it I couldn't wait to go home to go to bed. I stopped going to the gym, had no energy. I have since gained weight, mostly in the stomach area. On the upside, since taking prometrium in combination with Estrogel, my night sweats have all but disappeared. I hadn't slept a full night in years. Now I pass out before being able to count to 10. I feel much better because I am getting some much needed sleep. Will be taking HRT for the shortest possible length of time. Just trying to get me through the rough spot I experienced. Before taking HRT, I was coping with acupuncture and homeopathic meds but in April, the floodgates opened and my entire system just went crazy on me. Night sweats were the worse (that and not sleeping a wink and trying to work full time). I am going to continue taking it and hope that the negative side effects disappear after a while because the pros are better than the cons for me right now F 52 30 days
100 mg 1X day
6/20/2013
Email
 4  Perimenopause Side effects only when dosage is off. Initially I had some irritability and urinary/bladder irritation and not much help with insomnia and fatigue I was hoping for. Now that my dosage is right, I dont have the side effects and it has helped with sleep, bloating and fatigue. I suggest anyone starting progesterone/prometrium start off at a low dose from compounding pharmacy. My first doctor put me on 100mg since that is the only dosage available unless you get it from compounding pharmacy. This was too high a dose and caused bad bladder irritation. I went to another doctor that prescribed progesterone in 25 mg dose so I could start out low and adjust as needed. I started on 50mg and didnt have side effects and it started helping with the bloating, skin itching/dryness, insomnia issues. When it started to lose efficacy, I increased to 75mg, and it worked well again. I am now taking 75-100 mg nightly with good results. Helps a lot with bloating/PMS symptoms. I cant believe some doctors are starting people on 200mg -- no wonder the terrible side effects! You have to ramp up slowing with HRT as the body needs to get used to it. If you had a bad experience, as I did initially, I would suggest trying again starting on a low dose. It takes a good 30 days at least with all the bioidential hormone replacement for the body to adjust and it takes some tweaking. Its worth experimenting to get it right if you are having extreme perimenopausal issues as I am having. BHRT has helped my quality of life, but it has required patience to get dosage right. Everyone is different and starting on lowest dose is best. You have to be your own doctor for the most part. Most doctors are ignorant and not very good at dealing with this issue... F 44 6 months
75-100mg 1X day
4/7/2013
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 2  Menoupause symptoms Racing heart, numerous hot flashes, insomnia, jittery feeling into the next morning. Tried this in combination with Divigel (estradiol) for mild menopause symptoms, the worst of which is insomnia. The very first night I took this I noticed side effects. It made my heart pound all night long and caused numerous hot flashes that woke me up every hour. During the night, I felt exausted, dizzy and loopy yet I could not sleep. I still felt jittery the next morning. Too afraid to feel that way another night, so it's going right in the trash. Too bad, because it's expensive! F 49 1 days
100mg 1X day
2/8/2013
 3  Post menopausal symptoms If you have side effects, you may have high levels of progesterone due to drug-drug or drug-food interactions. DO NOT CONSUME GRAPEFRUIT PRODUCTS! The CYP3A4 enzyme clears most of prescribed drugs (substrates) from your system. Check to see if any of your meds or supplements are CYP3A4 substrates and or if they are inhibitors of CYP3A4. Grapefruit stops the action of CYP3A4 gut enzymes completely in 30 minutes, permanently and irreversibly. You renew the enzyme in over 24 hours, so taking grapefruit products separately from your drugs does not help. When you can not clear substrates, levels of them get too high and side effects, even fatalities, may occur. Many herbal supplements are CYP3A4 inhibitors as well. Do not take them. Ginkgo, garlic, turmeric, for example. Research every substance for CYP3A4 interactions. Be well! F 57
100-200mg 1X day
1/27/2013
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 1  Perimenopausal OMG! I thought I was having a heart attack. 200mg Oral. Resting heart rate over 140 for 6-8 hours while sleeping, over 100 the next day. Vomitting all night, Sweating, so weak had to be carried to bathroom. Headaches.Stopped taking immediately. Cannot imagine taking for 14 days. Maybe it should have been a suppository at 200mg? on Estridot but goal was to create period. F 47 1 days
200 mg 1X day
1/8/2013
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 5  menopause No adverse side effects observed Sleep, glorious sleep! I'm fairly certain this is the first time I have experienced a full night of uninterrupted sleep in over a year. I also have a greater sense of well-being. Very pleased indeed and hope I can take it forever! F 51 7 days
100 1X day
8/31/2012
 3  PCOS Extreme dizziness, "drunk" feeling, constant headache, lethargy, uncontrollable crying, difficulty concentrating I hate having to take it, but it works in terms of helping me have a period. The first 2-3 days are the absolute worst. I can barely get out of bed and when I do, I walk around in a daze and anything will make me cry. I tried the 100 mg dosage which had less severe side effects, but I had to take them for a longer period of time (which I didn't like). So, I sucked it up and went for the 200mg. I take it before bed to help with the dizziness, but it still lingers the following day. F 32 12 days
200mg 1X day
8/31/2012
Email
 5  low progesterone after a TAH/BSO None other than menstrual type cramps. My appetite is wayyyy down, no more swelling in my hands and face! :) SO happy! F 45 7 days
100 mg 1X day
8/10/2012
 5  Menapause symptoms none really helps with sleep My OBGYN who is a researcher informed that Prometrium is recommended along with Vivelle Dot to combat the risk of breast cancer. F 51 2 years
100 mg 1X day
8/7/2012
 1  menopauase with premarin Nausea every day, stomach irritation, constipation, HEADACHE, pain in calves, blurred vision, sore ,enlarged breasts. It is hard to know for sure which drug is causing all these problems, but I think it is the prometrium, for the nausea and headache. It helped my depression, but I can't tolerate the side effects at this time. Will quit both and start to get rid of the side effects/ F 50 60 days
100mg 1X day
8/7/2012
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 3  Help with implantation after IUI Severe joint pain; fatigue; bloating; sore breasts; moodiness; F 39 2 weeks
200 mg 1X day
7/24/2012
 3  Low Progesterone/TTC Have to drink with a lot of water or it feels like it is sitting in my throat. Then I start to feel jumpy and tingly, eyes feel puffy- I just feel off after taking it. Heart flutters also. I do not feel sleepy after taking it, but dr. told me to take it before bed. Lay awake for a while. Then I have really weird and vivid dreams of people, places or thoughts from the day before. Wake up after 5 hours in the middle of the night and can't go back to sleep. Do not feel tired in the morning. I think it has opposite effect on me- makes me hyper. Not loving this but taking it to higher progesterone levels and in case I do concieve. I take it starting the third day after ovulation through day 12, and I assume will cont. if get a PPT. F 28 4 days
200 1X day
7/19/2012
 4  Panhypopituitarism Strange dreams. In this 3rd week of taking, I'm watching my stomach distend like a basketball. I am hoping this is temporary. Since becoming panhypopituitary (due to surgeries) in my 30's I lost all my hormones. I had to replace and balance so many other hormones and vitamin deficiencies that the doctors were not ready to deal with the female hormones until everythign else was balanced. That took almost seven years... seven years I would not wish on my worst enemy. In my first week on this 100mg of Progesterone and an estrogen patch I felt like myself for the first time in years. I slept without waking up 6 or 8 times like I had been doing and I could THINK clearly. All the awful night sweats stopped and all the uncharacteristic despair and crying went away. I no longer felt cold, old and tired 24/7 and wan't getting flustered over stupid little things. I even got a sense that my libido was returning. All was wondeful but now it's the third week and I can no longer get into any of my pants. If I see myself sideways in a mirror it looks like I swallowed a basketball. I also could not sleep at all last night with those old aches and pains and woke up to two pimples and I haven't had a pimple since I was a teen. I REALLY hope this is a temporary glitch because those 15 days/nights of feeling like my normal self again were the best gift I've ever received. F 45 17 days
100mg 1X day
6/29/2012
 5  perimenopause, bleeding, anxiety In the beginning - lethargy, depression, drowsiness, breast tenderness The side effects were in the 1st month only. Now I take Prometrium 100 mg 12-14 days a month, vaginally, before going to bed. In the beginning I had to use some Estrogel to get out of the depression, However using Estrogel led to extra bleeding/ spotting and anxiety, so now I am using Prometrium only. Lack of progesterone in the perimenopause is the reason women get anxious because of estrogen fluctuations, (Natural) progesterone down-regulates estrogen receptors thus reducing this sensitivity and diminishing anxiety. One more comment: progesterone creams and gels did not help me at all, since progesterone, unlike Estrogel, is not absorbed by my skin. Vaginal way is the best way to take it, also for endometrium protection. F 49 3 months
100 1X day
5/4/2012

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