PROMETRIUM Reviews (PROGESTERONE)

Average Rating: 3.1 (568 Ratings)

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 ESTROGENS PROGESTINS

 Type: Rx Drug

  

PROMETRIUM  (PROGESTERONE):  Progesterone is a type of female hormone (progestin). This medication is similar to the progesterone that your body naturally makes and is given to replace the hormone when your body is not making enough of it. In women who are not pregnant and not going through menopause, this medication is used to restore normal menstrual periods that have stopped for several months (amenorrhea). Progesterone is also used as part of combination hormone replacement therapy with estrogens to reduce menopause symptoms (e.g., hot flashes). Progesterone is added to estrogen replacement therapy to reduce the risk of cancer of the uterus. This medication is not for use in children. Progesterone must not be used to test for pregnancy.   FDA Approval Date: 1999-10-15 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on PROMETRIUM: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR PROMETRIUMCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  HRT after Menopause My mother had a stroke after 2-3 months on Prometrium! She was in perfect health, and taking no other medications. She is now paralyzed on the left side; in a wheelchair, and must have someone with her 24 hours a day, helping with bathing, toileting, dressing, transferring her from place to place. She had been very active, and health conscious, and actually had the stroke while she and I were at a fitness center together. This has had a very dramatic affect on her health, and quality of life, and certainly was not in her plans for retirement. I am giving HER AGE in the age area. I would NOT RECOMMEND this product to anyone. F 71 2 months
3/7/2007
 3  Hrt I start spotting every time I begin the 10 day cycle for the progesterone part. I thought cycling would help clear the thicker lining. I don't know what the best dosage is for me. Can I use prometrium capsules intravaginally? Would I absorb it better? I am wondering if I am absorbing it. I have had endometrial hyperplasia with Vivelle dot .075 patch and have also been on continuous prometrium. My osteoarthritis in feet, hands and back have increased over the last 2 yrs. I am so frustrated. F 68 10 years
100
10/17/2015
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 4   F 64 8 years
100 1X day
11/10/2011
 1  hrt nausea, feeling full, pelvic pain, swollen abdomen, crying due to feeling awful, shaking hands, vivid dreams, throbbing in back when lying down, depressed feeling, after 3 weeks and 2 shots of this medication. I tried this because I had pelvic pain. Really created new places of pain and after 3-4 weeks and the shots, nausea, shaking hands, couldn't do anything felt so bad, felt irritable toward people who talked too long. I am disappointed that it didn't help, wonder how long will take to wear off. I also was prescribed Estratest, so could be some of that, too. But when I took hormones at age 50, estrogen didn't bother, only progesterone. This did not give me headaches which I had with the progesterone I took alone when I was 50 and the doses were divided to mimic your period. I don't know why they now combine the two hormones. This med did not work to my satisfaction and I became worse and worse. Thanks for this website and the info, it was very helpful to me. I don't know what will help my pelvic pain and other problems but hysterectomy, which I don't want. F 64 28 days
10/13/2007
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 2  Menopause Headache when I wake up. Blurry vision even when wearing glasses. Sinus problems. Biggest problem is muscle pain all night and day. Left side of arm, legs and hip. Continually trying to find a comfortable position. F 62 6 weeks
100 mg 1X day
1/6/2024
 5  menopause none I am taking prometrium 100 mg orally at night. I am also on the vivelle dot 0.05. The mood swings have gone. I was a loaded gun. My symptoms with irritability and emotional lability at a #10. All gone now. the severe hot flashes are gone. (I think that is the patch and not the Prometrium that took the hot flashes away???) The wakening at night from the hot flashes is gone. The vaginal dryness and dry skin are not. Lots of lubs on the market though. The one thing that continues is the awakening at night. I also have difficulty falling asleep immediately now it takes up to one hour to fall asleep. stopped all caffeine for 30 days and the problems with sleep still continue. My libido has improved 300%. . Laurel F 60 1 years
1X day
8/10/2011
 3  balance estrogen, night sweats Inner tube feeling around my stomach, breast larger & tender for awhile, bloated F 60 28 days
30 1X day
2/27/2011
 1  HRT Extreme dizyness, breast pain, irritable, leg cramps, strange dreams, tired. I have been on this drug for a sraight 110 days and my endocrinlogist tells me to take them until who knows? Plus the V-dot and testostorine cream. The side effects are horible & the exreme disoriented/dizzy feeling I get when I am inside of stores is very strange. Never received HRT when I had my ovaries removed 6 yrs ago until 11/2010. Was not given any by my female Dr. I was told I would not need it. Was she wrong! Did not understand what was going with me, was given antidepresent. Felt better but don't like taking drugs, I went off of them. Now HRT, don't know what to do? It is suppose to help my moods, hair loss, sex drive etc. Side effects are bad news, was not aware of them. I am afraid of the cancer risk, have lost 4 female family members. Just saw my endo doc, she told me to increase my MG, it would get better, the white Night she said. Help? I am healty & fit. F 60 110 days
100MG 1X day
2/27/2011
 1  Menopause - to thin lining Horrible anxiety, panic attacks that I had never experienced before, waking up every hour at night with anxiety, crying, over emotional, loss of appetite, felt I needed to eat every few hours, dizziness and nausea. I couldn’t figure out what was wrong with me. Two trips to Er for them to tell me everything was fine. Thought I was going crazy until I read many reviews of women experiencing the same issues. The one positive thing to come out of taking this was it made me bleed which thinned my lining. F 60 8 weeks
200 1X day
6/18/2021
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 4  Negative Symptoms of Menopause I have only taken it for 4 days, however I hae been waking up with a headache on both sides of my head in the temple area-to over both eyes, some naseua, and some cramping. I experienced some heartburn the 2nd day. I am giving this medication a chance. In spite of the side effects, I feel mentally more clear-less depressed and more energy. It is helping with my sleep. Prior to taking this medication I felt dead inside, just barely able to get out of bed...I had no energy, and was experiencing severe depressive symptoms. I have always been active and my last MD was unsympathetic "pick yourself up by the bootstraps" type and I just couldn't. My new MD ordered tests that revealed very low levels of Vitamin D and specific hormones. My ability of my thyroid to produce needed hormones appears depleted from chronic stress.I feel hopeful as in spite of growing older I knew it was not supposed to feel like I was dead already...My appetite and cravings have decreased in just the 4 days and as I said my energy level and clarity of mind has improved. I have always had migraine headaches and these are not migraine and I am praying they will go away as I become more adjusted to the medication. More tests are being conducted and I will continue to post updates. F 59 4 days
200 1X day
1/9/2011
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 4  adjunct to estrogen patch Breast tenderness, joint pain No depression as I take an anti-depressant; no dizziness or sleepiness after the initial few days; I take it in morning with other meds (no one instructed me to take it at night!) F 59 10 days
5/16/2006
 1  Menopause Skin rash that looked like chicken pox. Red itchy blisters which then changed into smaller itchy spots and by three months were less frequent but still appearing. I did some research and found peanut oil is in the ingredients of Prometrium. I am highly allergic to peanuts!!!! Why anyone would include peanut oil in a drug is beyond me. F 59 90 days
100 1X day
10/13/2021
 4  to stop "hot flashes" Elevated blood pressure, dizziness (especially after sleep), bloating, lack of energy, mild headaches, leg cramps at night After complaining about the more frequent severe night sweats (hysterectomy in 2007), I took a saliva test that showed my progesterone level was low. Already wearing a low dose estrogen patch, my doctor prescribed Prometrium to balance out my hormone levels. The night sweats ended almost immediately, but gradually the other symptoms began. Until today while having a procedure at a Surgical Center did I suspect this drug as causing the problems I am encountering. My BP has always been 115-120/75-80. I had not had my BP checked since I began taking Prometrium until 4 or 5 weeks ago. I was shocked at the readings. Most days now, it's anywhere from 134-155/80-85. The other effects began about 2-3 weeks after I began Prometrium but I just didn't make the connection until today. I did forget to take the Prometrium last night and will certainly FORGET it from now on. I have left a message with my doctor and hope to hear from her Monday. F 58 3 months
100mg 1X day
10/1/2010
Email
 1  hormone replacement menopause Can't believe soy was added to this med. If allergies and thyroid aren't on the rise as it is. Had a horrible experience didn't even tell me there was soy in it when I filled it last!Liked the older formula much better.So sorry they had to go and change this formula. I think it would be more profitable to be changed back to the original formula there are many generics with soy in them. Thats why people were willing to pay for brand . NO SOY. F 58 10 years
100 MG 1X day
3/7/2017
 5  HRT Breast tenderness, increased appetite, and fluid retention. I had a total hysterectomy and struggled with insomnia and night time panic ever since. I've spent huge amounts of time and money trying to resolve these problems, but both stopped almost immediately when a GYN started me on Prometrium 100mg before bed. Her premise was that the estrogen I take for severe hot flashes (I use a Femring) was overstimulating me and that it needed to be balanced by the calming effects of progesterone. I stopped the Prometrium for a couple of weeks because of cost and side effects (actually very tolerable relative to panic and insomnia!), but the original problems returned with a vengeance. I'm back on the med and thankful for it---sleeping well and without panic attacks. F 57 2 years
8/9/2008
 3  Post Menopause Extreme lethargy I take a tablet at night which knocks me out but I wake with a headache and nausea and a feeling of extreme tiredness that lasts for most of the day. I am taking it in conjunction with an estrogen gel which has all but got rid of my night sweats. I just hate how tired I always feel now F 57 60 days
100mg 1X day
12/31/2020
 3  Post menopausal symptoms If you have side effects, you may have high levels of progesterone due to drug-drug or drug-food interactions. DO NOT CONSUME GRAPEFRUIT PRODUCTS! The CYP3A4 enzyme clears most of prescribed drugs (substrates) from your system. Check to see if any of your meds or supplements are CYP3A4 substrates and or if they are inhibitors of CYP3A4. Grapefruit stops the action of CYP3A4 gut enzymes completely in 30 minutes, permanently and irreversibly. You renew the enzyme in over 24 hours, so taking grapefruit products separately from your drugs does not help. When you can not clear substrates, levels of them get too high and side effects, even fatalities, may occur. Many herbal supplements are CYP3A4 inhibitors as well. Do not take them. Ginkgo, garlic, turmeric, for example. Research every substance for CYP3A4 interactions. Be well! F 57
100-200mg 1X day
1/27/2013
Email
 1  insomnia Stroke like symptoms: unable to focus, unable to walk. Also expereinced painful breasts, pain on right leg, dizziness, heart palpitations, anxiety. Warning--take upmost caution and do all research before considering this drug. This was recommended to me by a Naturopath Doctor. I made the mistake of not researching this drug before I took it, and so thankful I did not start on a higher dose. I question that this drug is even on the market, as in my opinion it should not be. F 57 14 days
100 mg 1X day
9/25/2014
 5  Post menopause Love Prometrium, which is micronized bio identical progesterone. Have also started trying touche compounded biest (E2/3) and progesterone, which is also amazing. Great sleep, better mood F 56 2 years
100mg 1X day
9/11/2022
Email
 5  Menopause Sleepiness, which, when taken at night, is a positive! I took Prometrium 200mg day 1 - 15 each month for about 8 years. At first had problems with sleepiness, but when switched to taking it at night, it solved my insomnia problem. I had no periods or spotting until recently, so am now taking it daily all month. This solved my spotting problem. I'm very happy with this medication. F 56 8 years
6/26/2007
  

PROMETRIUM  (PROGESTERONE):  Progesterone is a type of female hormone (progestin). This medication is similar to the progesterone that your body naturally makes and is given to replace the hormone when your body is not making enough of it. In women who are not pregnant and not going through menopause, this medication is used to restore normal menstrual periods that have stopped for several months (amenorrhea). Progesterone is also used as part of combination hormone replacement therapy with estrogens to reduce menopause symptoms (e.g., hot flashes). Progesterone is added to estrogen replacement therapy to reduce the risk of cancer of the uterus. This medication is not for use in children. Progesterone must not be used to test for pregnancy.   FDA Approval Date: 1999-10-15 (Sources: U.S. Centers for Medicare Services, FDA)

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