LUPRON DEPOT Reviews (LEUPROLIDE ACETATE)

Average Rating: 3.0 (783 Ratings)

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 ANTERIOR PITUITARY HYPOTHALMIC FUNCTION ANTINEOPLASTICS

 Type: Rx Drug

  

LUPRON DEPOT  (LEUPROLIDE ACETATE):  Leuprolide is used to treat advanced prostate cancer in men. It is not a cure. Most types of prostate cancer need the male hormone testosterone to grow and spread. Leuprolide works by reducing the amount of testosterone that the body makes. This helps slow or stop the growth of cancer cells and helps relieve symptoms such as painful/difficult urination. Talk to your doctor about the risks and benefits of treatment.   FDA Approval Date: 1989-01-26 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on LUPRON DEPOT: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR LUPRON DEPOTCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Endometriosis Dizziness,anxiety, chills, pain in the neck, shoulder and pelvic areas. I was feeling well and recovering from surgery. One week after my Lupron injection, I felt worse. The side effects are not worth going through for the next 6 months so I will discontinue this therapy. Ibuprofen is sufficient to relieve my menstrual cramps and there is no way I am going through this rollercoaster. I don't want to disrupt the quality of life, my family and career. So far, my doctor has presribed me estradiol patch and it is offering me some relief although I still have some body aches. F 44 7 days
4/15/2005
 1  Endometriosis Hot flashes Profuse Sweating Hip joint pain Sacrum Pain Ilium Pain F 44 3 months
5/12/2006
 5  endometriosis mostly mild hot flashes I must be the poster child for this stuff!!! It's the first time in YEARS that I have been pain free. I am done with my meds (maximum 6 months per the FDA) and wish I could continue. F 43 6 months
10/18/2006
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 5  migraines/2cifhystterectomywillhelp hot flashes, hot flashes and night sweats during sleep, one period and 14 days of spotting with first injection, irritabilaty- no pain at all I have had cyclic migraines for over 15 years - after visiting a very renowned headache clinic, top notch nuerologist, pain management dr's etc.. no one would listen to me. I knew my periods where the source of my migraines and have been asking for a hysterectomy for years. The dr's. would just blow me off citing "there is not enough evidenc to prove that a hysterectomy will cure your migranes. After being chronically anemic for years, my hemotalogist and ob cunsulted and FINALLY my ob decided to put me on Lupron. He indicated that if the Lupron worked and eliminated the migraines, he would then preform a hysterctomy. After my first shot, I had a period a bled for approx two additional weeks. It wasn't until I had my second shot that I've had substantial success. For the first time in years I did not have to visit the er to get a shot af narcotics for out of control migraines! They have greatly reduced to just a few, very low on the pain scale and the fact that I have a sinus infection makes me wonder if that may be the culprit. BONUS: I have lost over fifteen pounds without trying or changing a thing and the weight is still coming off - I know each body reacts differently, but for someone who has suffered almost half her life with debilitating migraines-I think it is an answer to a prayer, L.B. F 43 2 months
7.5 2X M
2/12/2010
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 5  endometriosis hot flashes, vaginal dryness After add back therapy, I felt better than I have for a long time. F 43 6 months
9/5/2009
 4  Hydanitis, severe infections MRSA I had already started menapause. headach, night sweats, hot flashes, just started with anxiety and big time joint and back pain. My condition is different from everyone else that i have read, but the bottom line is I don't want my infections killing me if i am able to take this shot and stop the hormonal effects causing my infections. the side effects suck. I just need to hang in there for 6 months and then have my ovaries removed. My mother had ovarian cancer. Since having my injection 3 weeks ago, I have had no infections. F 43 3 weeks
2/29/2008
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 4  Large fibroids, heavy bleeding Minimal hot flashes, mild insomnia ABSOLUTELY NO SEX DRIVE-putting a serious strain on my relationship. I'll be re-evalutated this week to see if the fibroids have shrunk. Definitely stopped the excessive bleeding. F 43 3 months
10/20/2006
 4  Endometreosis/Fibroid Tumors Weight gain,memory loss,severe hot flashes,fluid retention,insomnia,muscle pain, sore throat, depression, mood swings, anxiety, need I say more...... I have just finished my second 6 month treatment July, 2005. My first 6 mo treatment did not completely take care of all the pain and discomfort associated with endo. I did discover with the help of my Family care Dr. that there was medication to help with all of the severe mood swings, anxiety etc. She prescribed Zoloft so that my family would not divorce me, and added Ativan o.5 mg. to help the insomnia. My family is now able to live with me and I am a calmer person. Lupron is a very good drug for the symptoms associated with endo, however, I highly suggest that you let every Dr. within your medical circle be informed that you are getting this treatment. I learned the hard way by not advising all of my Drs. If you are diabetic like I am, this treatment may effect your blood sugar readings, and also may effect cholesteral levels. I have decided that I will not have any more treatments. My body is tired from the side effects and I feel that another treatment is not neccessary. My Dr. refuses to give me a hysterectomy, which I feel will be my only cure. I have lived with endo since my teen years and was blessed with 2 boys. I hope someday there will be less drastic treatments for women who suffer this painful disease. F 43 2 years
7/18/2005
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 4  uterine fibroids, anemia pain in joints, weight gain, retaining water I took the 11.25 3 month injection. When my doctor first offer it to me I did not want to take it but then 2 months later I had the worst menstrual cycle every--it made me anemic. I was rushed to the emergency room from my job. My anemia was so severe that I could not have a subtotal hysterectomy. I felt terrible. I am on iron and this medication. Even though I have the above side effects, I am thankful that I am not bleeding like before--I could not live bleeding like that. And the iron regime I am on is making me feel somewhat normal. I have been able to start back exercising--even though my knees and leg hurt but not to the point where I can not function. My goal is to be able to have the surgery which is scheduled for Sept 18th--so I am hanging in there and trying to keep active as much as possible-especially yoga--knowing that all of this is temporary. F 43 1 months
7/28/2007
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 3  fibroids I did have the hot flashes during the day, it wasnt until after 2 months of use that I developed night sweats. Currently I am experiencing bone pain in my wrist and back, I did have bone pain after my first injection but it didnt hit me as fast as it did this time..(got another injection 5 days ago) The Lupron injection did shrink my fibroid and slowly lessen my bleeding. It can for women help with bleeding, but lately I have done alot of research on Lupron and I think this will be my last shot, there alot of unknowns about long term effects and for me the side effects are tough to take. F 43 4 months
9/29/2004
 3  ENDOMETRIOSIS On it for almost three months so far. 1st month cramps,period,headache. 2nd month hot flashes, nightmares,headache.3rd month partial some hot flashes then no hot flashes and menstruation began again. Although the period was less painful than before. F 43 3 days
8/14/2005
 3  ovarian remnesed disease, cyst. depression,moodswings,nasea,vomiting,hairloss,hotflashes,nightsweats,tackacardia,anxiety,crying alot,weightgain,coldsweats,skinrough has srunk cyst, but i am misreable, have to take 4 more injections, dont know if can or not , worse time in my life, will not ever take it again, F 43 8 months
2/10/2009
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 2  endometriosis horrible mood swings, depression, hot flashes, night sweats, nausea, vomiting, dizziness, lack of concentration and focus, severe headaches, insomnia The first shot wasn't so bad, but 3 hours after the second shot, my life became a nightmare. I'm supposed to take the third shot tomorrow and I'm terrified of what is going to happen. I have a history of anxiety and depression and this treatment has sent me over the edge. I can barely live with myself. Four more months!...I'm not sure if I can make it through this and come out with my sanity intact. For the first time in my history of being single, I am actually glad I do not have a mate to see me going through this! On top of everything else, I am still experiencing some pain from the endometriosis. Is it worth it? I guess we'll see. F 43 2 months
2/27/2009
 2  ENDO /Ovarian cysts I had my menses for the first two injections. Then headache, severe bone and joints pain,back and stomach pain and constipation,low sex drive, tired...,poor slept but no hot falsh still waiting for them. I have had 5 injections. I have been hospitalized for a bowel obstruction and a second time with stomach pain , nausea and vomiting... F 43 5 months
9/13/2006
 2   The apathy, depression, lack of concentration and zombie-like state (eyes don't focus properly ptsd-like)are my most troubling side effects though I have hotflashes, joint and foot pain, migraines, nausea and vomiting, and the inability to sleep soundly. ADDED: itching too, more on my scalp but body itching as well. I called my doctor and begged for something to make the depression better. I now have the 7 days estrogen patch. It helps but at the end of the 7 days stretch I cry at the drop of a hat and feel like I'm drowning in hopelessness. This is most concerning since I am a single mom working full-time and trying to go to school. I am unable to concentrate on school/work assignments and most mornings I want to cry at having to face another day like this. This is my second 90 day shot and I am so glad it is to be my last one. I can't believe this drug will be coursing through my veins for another 3-4 months. I thought the pain I'd been having for the last 2 years was bad but this "remedy" is enough to wear a girl down. At first my libido was high, now I don't care much. I can't wash my hair as often as my scalp itches after shampooing and I don't want the all-over body itching;so at times I become my own libido-killing organism. F 43 4 months
1X O
10/4/2010
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 1  Endometriosis Severe Depression, Night sweats, Hot Flashes, Mood Swings,insomnia, Forgetfulness, vaginal dryness, constant yeast infections, painful sex, Ovarian Cysts, Hip & knee joint pain, Infertility (POF-Premature Ovarian Failure), Osteopenia I had my injections back in 1994-95 when I was in my 20's. The only side effects I was told about were that I might get a little emotional after about the 4th injection and that I would have some hot flashes that would go away after inj's were stopped. What I ended up with at the time was severe depression, vaginal dryness, night sweats, hot flashes, terrible mood swings. The forgetfulness, depression, insomnia, night sweats and hot flashes never went away after I quit taking the drug. I kept complaining to doctors about it, but they never bothered to test my hormone levels and told me that I was too young to have night sweats and hot flashes and as for the vaginal dryness I should just use KY! I had never had a yeast infection prior to using Lupron now I get them constantly. Finally in my late 30's after complaining to doctor after doctor about these continued symptoms, my husband and I were not able to get pregnant on our own, so we visited a reproductive endocrinologist, I told her of my on going symptoms and she tested my hormone levels right away and diagnosed me with POF(premature ovarian failure) She said the reason for the hot flashes, night sweats, vaginal dryness, depression/mood swings all these years was because my ovaries were shutting down, that it was basically like I was going through an early menopause and this was causing my hormone levels to go crazy, at one point my hormone levels were that of an 80 year old woman. We were unable to concieve and I even F 43 6 months
1X M
11/14/2010
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 1  Fibroids, Heavy Period hot flashes, hot flashes and night sweats during sleep, muscle & joint weakness & pain, extreme fatigue, sadness, itchy skin, craving for chocolates so for the past week i've been eating a lot, lot of chocolates Two days after I took the depot lupron shot, I had an allergic reaction..had difficult of breathing and swallowing, feels like my throat is closing...i can't even swallow my saliva, I panic and my husband took me to the emergency room. I don't recommend this to anyone, this is the worst thing i have done.... F 43 3 weeks
1X day
2/21/2010
 1  Pre-surgery for Lap and hyst High blood pressure, increased heart rate, deppression, anxiety, major leg pain, insomnia, muscle spasms, shivers and sweats, forgetfulness, irritabilty, cry for no reason, back pain, skin on face is dry and scaling, extreme fatigue and feeling of hopelessness, lack of appetite , nausea, vomitting, diarhea I started a week ago with add back estrogen, now just crying a few times a day. I wish I would have never taken this drug and really hope these side affects wear off. Went into the hospital for a racing heart in the middle of the night, they are referring me to a cardiologist. I did stop bleeding and have less cramps. Feel free to eamil me if you are going through something similar. F 43 3 weeks
3.75 1X M
12/15/2011
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 1  infertility Joint pain, deep bone pain. Heart palpitations immediately after stopped taking drug. Mental confusion. Loss of degree of mental sharpness. Skin photo--sensitivity to sun. Took 5 months to purge SOME Of the drug from my system. Gained 15 pounds -- with NO CHANGE in diet and exercise. Gained 15 pounds -- NO ADDITIONAL CALORIE CONSUMPTION, and am on a very restricted diet & exercise program to lose BIG HUGE SPARE TIRE around mid section that did NOT Exist prior to lupron. Did NOT result in a successful pregnancy. Poisonous toxic drug Based upon my research, it KILLS men with prostate cancer at 65++ years of age. While I had heart palpitations, they have FATAL HEART ATTACKS. F 43 12 days
4/28/2009
 1  Fibroids Headaches(severe), facial pain/swelling, TMJ/ Trigeminal Neuralgia/ hypertensive Crisis/ Joint Pain /Insomnia, Anxiety/depression. Suicidal Ideations (Mainly because of how miserable this drug has made my life). Q I was diagnosed with Fibroids Sept 2023. It was recommended due to the larger being in my upper right quadrant. It would be beneficial to shrink the fibroids using chemical induced menopause (they make it sound so easy). Three months on they managed to spare me a large vertical incision but am left scared to death what is going on with my body. My doctor suspects TMJ (never had this before the shots). I have spent most of my time in bed. I have been to A&E with hypertensive crisis as a result was given an ecg (QT Prolongation and abnormal T and S waves). Am now waiting on a Echocardiogram and a visit to a Neurology Clinic. I sympathise with all of you who have been through the stress and upset this drug has caused. Without a doubt it is life changing for those who unfortunate enough to experience the more severe side effects. Can only plod on and try to carry on. Its been so distressing I can’t put it into words. I know for some its been a positive drug and helped in extreme debilitating circumstances. However without a doubt it should be only administered when a thorough indication of the risks are advised. I would not recommend this drug to anyone unless it is a last resort. F 43 3 months
1X M
3/29/2023
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