LUPRON DEPOT Reviews (LEUPROLIDE ACETATE)

Average Rating: 3.0 (783 Ratings)

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 ANTERIOR PITUITARY HYPOTHALMIC FUNCTION ANTINEOPLASTICS

 Type: Rx Drug

  

LUPRON DEPOT  (LEUPROLIDE ACETATE):  Leuprolide is used to treat advanced prostate cancer in men. It is not a cure. Most types of prostate cancer need the male hormone testosterone to grow and spread. Leuprolide works by reducing the amount of testosterone that the body makes. This helps slow or stop the growth of cancer cells and helps relieve symptoms such as painful/difficult urination. Talk to your doctor about the risks and benefits of treatment.   FDA Approval Date: 1989-01-26 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on LUPRON DEPOT: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR LUPRON DEPOTCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 2  To prevent menstrual cycle Not working I still have menstrual cycle F 47 3 months
1/25/2012
 1  to shrink fibroids count all side effects listed by others except weight gain this treatment did not shrink my fibroids, they grew :( so now I am worse off than before and my body is in total turmoil as I am coming off it, been spotting black yuck for over a week now after my last shot 6 weeks ago, NOT HAPPY! initially I thought they shrank because they were harder to feel from the outside but they just got softer. F 47 7 months
10/30/2008
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 1  Endo Hot flashes, night sweats, weight gain, water retention, NUMBING in fingers and feet..plus tingling in arms, hands and legs, fatigue, Extreme hip joint pain, No sex drive, can't sleep, thirsty all the time...feel lousy! I would like to know IF and when these symptoms will subside after I complete this nasty drug. I am not due to be seen by doctor for another months and will tell her I am not going to continue with the next 6 month session...I am miserable. F 47 4 months
5/28/2006
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 1  Endo Hot flashes, night sweats, weight gain, water retention, NUMBING in fingers and feet..plus tingling in arms, hands and legs, fatigue, Extreme hip joint pain, No sex drive, can't sleep, thirsty all the time...feel lousy! I would like to know IF and when these symptoms will subside after I complete this nasty drug. I am not due to be seen by doctor for another months and will tell her I am not going to continue with the next 6 month session...I am miserable. F 47 4 months
5/28/2006
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 1  fibroids headache,burning eyes,pain in the legs I started LUPRON 14 days ago. I still got my heavy, crampy,painful,bloated period today. I thought the drug would work immedietly .I am very dissappointed. F 47 14 days
6/15/2005
 5  large uterine fibroids hot flashes and night sweats Lupron Depot helped me tremedously. Although there were side effects, they were nothing compared to the relief from the pain of the fibroids. I am very happy with the results and would reccommend it to anyone. I feel like a normal person again. F 46 4 months
6/28/2005
 4  Fibroids n endrometris Hot flashes mood swings stiffness in fingers I took shot every 3 months totally 3 shots towards the end my pressure went up every moring my fingers be stiff F 46 3 months
2/2/2015
 4  Endometriosis Occasional night sweats, weight gain This is my 6th month on this medication. I get a shot every 3 months. I had surgery to remove my right ovary and fallopian tube due to cysts and endometrioma. My OB-GYN put me on this drug so I will be on temporary menopause and hopefully help with keeping the endo at bay. Don't get scared to try this med, each patient will react differently. Fortunately, I did not experience all the side effects that affected others. The worst side effect for me is the weight gain. But hopefully, I will lose it when I stop with the treatment. M 46 6 months
10/1/2008
 3  fibroids headaches sometimes, breast tenderness and some body pain, nothing major, but not sure if it is doing any good F 46 14 days
2/2/2005
 2  Uteran Fibroids Peiords ceased, mild hot flashes, occasional night sweats, moderate fatigue, moderate joint pain, mild restlessness, mild insomnia, mild depression. My gynocologist prescribed Lupron Depot injections to try to shrink fibroids that were found during a regular exam. The dosage prescribed was 6 monthly 3.75mg injections. I will be receiving the 6th injection in September 2009. A hysterectomy will be scheduled for early November 2009. Unfortunately, the injections did not shrink the fibroids as much as we had hoped (from 20 cm to 16 cm in 4 months). I was expecting the worst in terms of side-effects. I'm very pleased that they have been quite tolerable. F 46 5 months
8/25/2009
 1  endo neck swelling burning,feels like my throat is hot and water does not quench, headaches, hotflashes,cyst blewup, moody, blurred vision, chest pains, fatigue...all from 1 shot..I think I had a reaction to the shot F 46 1 times
1X day
8/11/2013
 5  Fibroids, hemmorage-like bleeding Day after 1st injection, woke with severe sore throat and flu-like body aches. That lasted 2 days. My throat remained scratchy for just over 3 weeks. Started getting hot flashes after 3 weeks. They started as mild and seem to be increasing in intensity as time goes on. Have needed lots of extra sleep - I'm exhausted by 9 at night and sometimes feel sleepy during the day (I'm usually able to function for weeks at a time on just 5 - 6 hours of sleep per night). Dry mouth/thirst. Gained 10 lbs in first 2 weeks; have put on another 5 in the last 3 weeks even though I have significantly cut back on my food intake. I know the side effects make the drug seem impossible. I was scared to death before starting the injections (especially after reading some of the comments on this Web site), but I'm glad I did. The first thing the drug did was STOP the bleeding. It has been years since I've had even a full day with no bleeding. The first 2 weeks after my injection, I had no bleeding at all, now I have some light spotting most days. What a relief! I feel like there's hope of getting my life back after all. I know that my side effects seem like a lot, but aside from the tiredness, they don't interfere with my life the way the bleeding did. And even the need to sleep isn't all bad, I've probably pushed myself too hard for years. I'm looking at (much of) the extra sleep as a way to relax a bit and take care of me. My sex drive has not changed - in fact, without all the bleeding I feel more sexual than I have for a long time. The hot flashes are annoying (I have stronger words for the more intense ones). I F 45 5 weeks
5/31/2006
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 5  fibroids, cysts and endometriosis follow-up to last post @ #4 rating...W/OUT addback therapy...increased hotflashes,sweats,chills,sleep reduction,(rt)ovarian cramping, some bloating,slight bleeding w/ bowel movements,tugging & pricking sensations in pelvic / abdominal area 3rd shot 3/4 & visit w/ dr., who is certain about endo, based on feedback after 3 months of lupron. An 8 yr chronic (Rt)lower back ache / pain has & is improving, began noticing after 2nd shot. Lupron gave me hope & validation that a 10 yrs list of growing / overlapping (some dibilitating) bodily malfunctions, do have a cause and a solution. Have had suprising results w/ several things, which gives me hope for others. One more shot 4/1 and a hysterectomy scheduled for 4/15/05. F 45 3 months
3/12/2005
 4  UTERINE FIBROIDS AND OVARIAN CYSTS INCREASED HOTFLASHES, ADDITIONAL PERIODS AND RIGHT SIDED OVARIAN CRAMPING. I BEGAN LUPRON DEPOT 1/6/05 AND SECOND SHOT 2/4/05. I HAVE HAD PERIMENOPAUSAL SYMPTOMS FOR 10 YEARS AND DIBILITATING PERIODS FOR 10 YEARS. BECAUSE OF THE PERIODS IT SEEMS THAT A MYRIAD OF OTHER BODILY DYSFUNCTIONS ARE RELATED....SPANNNING OVER 10 YEARS AND WORSE THE LAST 5 YEARS. MANY, MANY MANY DOCTORS LATER I AM LUCKY ENOUGH TO HAVE STUBBLED ACROSS THE DOCTOR WHO IS FINALLY HELPING ME. AFTER THE 3 MONTHS OF SHOTS A HYSTERECTOMY IS LIKELY. THE LUPRON HAS HEIGHTENED MY ALREADY PERIMENOPAUSAL SYMPTOMS, BUT I AM HANDLING THEM, BECAUSE I WANT MY LIFE BACK. NO OTHER DOCTOR HAS EVER MENTIONED, NOR OFFERED ME OPTIONS.....JUST IBUPROFIN AND ONE TIME AN ANTIDEPRESSANT. I AM NOT A MARTYRE AND NOR DO I RELISH THE IDEA OF FEELING LIKE AN ANIMAL CAUGHT IN A TRAP. I AM REALISTIC THAT THERE MEY BE LONG TERM SIDE EFFECTS, BUT I AM WILLING TO TAKE THIS CHANCE. THANK YOU F 45 2 months
2/7/2005
 4  suspected endometriosis Not sleeping well but OTC drugs are helping that. Mild hot flashes. Lower back pain. I had a hysterectomy 1/23/08 for severe pelvic pain. I kept my ovaries. I still had severe pelvic pain. I went to 6 different doctors looking for an explanation. New Dr. in Philly suspected endo. I get my third monthly shot Fri. The pain is getting better. Not like someone threw a switch and it all went away, but gradual "feeling better" each day. Two days forward, one day back. I love the days I feel good and am praying this is the answer. I have to go back to Dr. and find out what we do next. F 45 3 months
10/28/2008
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 4  fibroids Vaginal dryness and hot flashes, otherwise I feel fine. My energy level in increasing. I feel extra hungry however. No weight gain yet. M 45 2 months
1X M
5/14/2010
 4  Fibroids, anemia Fatigue My first injection didn't work and the bleeding did not decrease substantially. But a second injection given just three weeks later with an increase in norethin acetate (5 mg.) to three times a day eventually stopped the bleeding completely. My hemoglobin increased from 5.9 to 11.1 in five weeks using Lupron with relatively no side effects. I would definitely try this as a means of eliminating heavy bleeding or treating anemia. Just don't expect it to work perfectly after just one injection. F 45 2 months
3.75 1X M
7/1/2010
Email
 3  endometriosis fatigue, 20lb weight gain, tiredness, memory loss, bloated,vision changes, leg pain, abdominal pain, depression, very angry at times, hot flashes, sweats, On my 6 th shot and just want to cry thinking about it. My doctor wants me to try another month but I will give my self an injection once daily because the side effects were so bad he decided that one doce at a time was to strong for me. I don't even want another shot but I just don't want to go back to having so much pain!! I have gained 4 lbs in one week, is this crazy even the doctor witnessed this because I was there for one shot and my anual appt and then I became sick with other symptoms now and he weighed me and said wow you did gain 4lbs in one week. I now have been experiencing stomach pain, very bloated, in 2 weeks I went up 2 sizes. Awful feeling I just want to cry. I will be going for more tests tomorrow and something tells me that I am gonna tell him to schedule me for a hystorectom because I just can't deal anymore. I am 45, thank god I have twins. F 45 5 days
3 1X M
9/27/2012
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 3  Shrink fibroids before surgery Severe muscle and joint ache. Loss of concentration, moodiness,jittery,and mild depression, headache. Feels like a severe case of the flu. Period never stopped but did slow down. Was scheduled for 3 shots but I can only take 2. Too painful. It hurts to open my car door. I hope this wears off soon.Although it feels like the fibroids are smaller. F 45 2 months
1X M
2/11/2013
 3  Endometrial ovarian cyst, fibroids HOT FLASHES!!! and in between hot flashes, feeling too warm, and then freezing. Anxiety, some depression; weight gain; Hot flashes wake me up about 4-5 times a night and anxiety makes it hard to get back to sleep - I am constantly sleep deprived, irritable and depressed. The only good thing about Lupron so far is I no longer have heavy periods with flooding! What a relief!! I have no periods at all in fact. However, my ovary still aches, so I'm not sure if any benefit is happening there yet (the cyst is supposed to reduce in size or go away), but I am supposed to be taking it for another 3 months, so maybe it's too soon. I'm starting to get used to the hot flashes, but I dread nights since sleeping is so difficult now. I can't wait until I am my old self again (minus heavy periods?). I hate this medication, so since I have to grin and bear it for the next 3 or more months, I hope it works! F 45 3 months
4/2/2007

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