LUPRON DEPOT Reviews (LEUPROLIDE ACETATE)

Average Rating: 3.0 (783 Ratings)

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 ANTERIOR PITUITARY HYPOTHALMIC FUNCTION ANTINEOPLASTICS

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LUPRON DEPOT  (LEUPROLIDE ACETATE):  Leuprolide is used to treat advanced prostate cancer in men. It is not a cure. Most types of prostate cancer need the male hormone testosterone to grow and spread. Leuprolide works by reducing the amount of testosterone that the body makes. This helps slow or stop the growth of cancer cells and helps relieve symptoms such as painful/difficult urination. Talk to your doctor about the risks and benefits of treatment.   FDA Approval Date: 1989-01-26 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on LUPRON DEPOT: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR LUPRON DEPOTCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 3  pre-surgery for fibroids Never experienced a hot flash, so not sure if I'm getting them. I do get 'warm' every so often, but not to the extreme. I get headaches, but always did have menstrual migraines before, so that's nothing new either. I'm taking Norathindrone with these shots so maybe that's doing it's job?? I'm taking Lupron to prepare for a laproscopic hysterectomy. I've had a Fibroid Embolization done, which did nothing. I've had heavy periods for eight years! My doctor warned me that after the first shot of Lupron, my bleeding may get worse for a while. Her words... "it may kick it up a notch." After my first shot on 11/20/07 I had a cessation for a while. Then I got my period again on 12/9/07. I still had it when I went for my second shot (11.25 mg)on 12/17, and my bleeding raged on for another 10 days! It stopped for about 7 days and it just started again! I just hope the Lupron's doing its job, because I was already chronically anemic - I don't see how having my period every few days will help anemia. And I'm taking a slow release iron pill on top of everything else! I'm praying the Lupron is at least shrinking the fibroids as I don't want to resort to a conventional hysterectomy! I rated this a 3, but I'm not sure if I can say it's working. I'm still five or so we F 54 48 days
1/6/2008
 1  Endometriosis All the common "temporary" side effects of menopause; plus some I was only life-threatening allergic reaction the year following treatment. My autoimmune system went wacky. Heart issues, nerve damage, I began passing out from hypothyroidism. Years later I was dx; with a thyroid goiter.and a brain aneurysm.Too many other Dx to list. Please do not use Leuprolide Acete / Lupron Depot! You may not get to live long enough to regrete it. They "Lied by Omission" Left out important information like it is an ".Antineplastic that kills "Healthy Cells as well as Cancerous Cells". They also said all side-effects are temporary. LIE!, LIE!, LIE, I was only 32. Why has the FDA not restricted this drug for Cancer patients only??? Another Thing For President Trump to Make Right... F 54 6 months
3.75 1X M
3/13/2017
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 1  To induce menopause Muscular pain in my legs Painful intercourse Arthritic pain in my hands The muscular pain in my legs lasted 6 days and was constant, day and night. Two days after exercise, a sore muscle turned into strong pain in my shoulder for a week. Intercourse was extremely painful for a week (could not have sex). Moderately painful for 3 weeks. Arthritic pain in my hands every morning F 54 5 months
7mg inject
12/26/2019
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 5  adenomyosis, ovarian cysts, fibroid Hot flashes (with cold flashes afterwards), night sweats, slight memory loss, some hair loss in upper pubic area I took one injection per month from 2/06 - 7/06. It's been 10 weeks since my last shot. I'm still having the flashes and night sweats pretty bad but was told all side effects would be gone within 12 weeks. I had a pelvic sonogram a few weeks ago and my one small fibroid and 2 ovarian cysts are gone. My period has not returned. I am so ready for these flashes to be gone but I would say that this shot was truly worth it because I did not want surgery. I will report here again if and when my period starts back up and if the adenomysis still bothers me after the shot wears off. F 53 6 months
9/28/2006
 5  adenomyosis, ovarian cysts, fibroid This is the 3rd time I've written here. Hot flashes and night sweats were about my only side effect and in my opinion were pretty severe, but they were worth it because the 6 months of shots got rid of everything... The flashes finally stopped almost 15 weeks after the last shot. My period has not started back yet. I should say that I am 53 years old and the women in my family don't go thru menopause until they are 63, so most likely I have a ways to go until I go thru it naturally. F 53 6 months
11/3/2006
 4  2 ovarian cysts, adenomyosis First month cold flashes and a few small headaches. 2nd month hot flashes plus cold flashes, night sweats, insomnia and memory loss. The first week my bleeding was worse than it had been but by the 2nd week it had stopped completely for the first time in 2 months. I am approved for 6 monthly shots...have had 2 and get the 3rd one in 2 days. I have not been re-tested yet to see if the cysts are shrinking. F 53 2 months
4/26/2006
 4  Adenomyosis, ovarian cysts I reported after 2 shots and now I'm in my 3rd week after my 3rd monthly shot. The hot flashes have gotten alot worse and then afterwards I get very cold most of the time. I'm not sure how this is going to affect me when the heat and humidity of summer get here. Dr. still hasn't tested me to see if the cysts are shrinking so I can't comment there. I have slight memory loss, and night sweats which have gotten worse this month too. My heavy daily bleeding stopped the 2nd week after the first shot after getting worse the 1st week. If I find out the cysts have shrunk I would say it's worth the side effects I'm having. F 53 3 months
5/17/2006
 2  Prostate cancer Hot Flashes, Joint pain, Neck pain, Tender & larger 'breasts' Perpetual tiredness + haven't put together >3 hrs sleep continuously in 1.5 yrs without chemical help. Libido=0, if the penis shrinks any further, I'll have to remove Mr in front of name. The original plan was 12 injections, coming up on 5 & I'd get off tomorrow except "does it make these 5 a waste of time etc?" I'll be asking next visit b/c if there is little difference. I get the shot in the butt, the 1st injection site on one side still hurts after >1 year. M 53 1.5 years
2/17/2008
 2  bleeding fibroids Migraines, Chest pain, hot flashes, severe joint pain, mood swings, High blood pressure. The bleeding has improved. I rarely have side effects with prescription drugs and usually react quite well to prescriptions. Not this time. I'm a wreck. F 53 5 months
4/23/2009
 1  uterine fibroids hot flashes, night sweats, weight gain, insomnia, joint and bone pain, osteoporosis I had two injections 3 months apart. I stopped the injections after 6 months. I gained 30 lbs and work out 6 days a week and cannot lose a pound. My body was strong before and now I have chronic joint and bone pain and my body feels so weak. I never sleep thru the night I feel as if I aged 20 years over night. I went into menopause and never came out. It has been 18 months since my last injection and my body is still a mess. I would NEVER have taken this medication. F 53 6 months
8/10/2009
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 1  prostate cancer 13.7 PSA gleason 7 I refused surgery, I won't have chemo. At the time May 2, 2009 I thought brachytherapy was my only option. Then I found proton therapy. I had 2 weeks of tests done. ...>MRI Pelvis w/wo contrast NM Body scan-whole body ...>NM inflammatory prostascint test ...>Prostascint scan ...>CT ABD pelvis scan with contrast ...>will get a transrectal ultrasound in 2 weeks The cancer has not spread outside the prostate. While in testing, away from home, the radiology oncologist recommended LuPron Depot 22mg. Not aware of the side effects I consented. After returning home I have found this was one of the worst mistakes I have ever made. This drug has so many side effects, major side effects not just the head aches and weight gain. Then after doing some major research I found a drug that would help considerably if I had "NOT" taken the Lupron. Now it is to late for the alternative, "Low dose Naltrexone", I am in search of another method over radiation Lupron is a pharmaceutical get rich drug. Please do your research and the side effects and how it is affecting peoples lives. Don't consent until you know everything you can about this drug. M 53 25 days
5/26/2009
 1  uterine hemoraging/adenocarcinoma I had 2 injections Dec.27, 2004 and again Jan. 19, 2005 I was diagnosed with uterine cancer on Feb. 21, 2005. I had 2 weeks of heavy bleeding in between and when the Dr at emergency checked my hemoglobin was at 81.Side effects started with tingling altered sensation in my hands up to my shoulders and feet up to my ribs. Other side effects were severe muscle spasms and pain in my muscles and joints, eyes sensitive to light staggering walk, dizzy, unbalanced and I feel like I am going to fall down. I have occasional double vision,very little sence of smell and taste and some of my favorite foods now taste terrible. I have acne, my nails have little ridges from side to side, my hair was curly and appears to be less so.I have headackes, and sore tender breasts, a lot of shaking and fatique. Short term memory problems lots of anxiety and crying. Todays date is Dec. 6th 2005 and my neurologist told me today that these symptoms are probabley permanent but that he cannot say or won't say t Please contact me if anyone has any suggestions for me. I don't know what to do,,, I cannot work like this and we live on a very limited income..... I used to be able to work and contribute to our household.I was told that I would have a few night sweats from these injections. Do you think these side effects are permanent? Is there any suggestions or any compensation? F 53 4 weeks
12/6/2005
 1  Endometriosos Mild relief of symptoms for first 3 months; less deep cramping, less pressure on back from swelling. Then, after another month, severe bone and muscle pain throughout body. Got MUCH worse after 5th injection. I believe Lupron sped my onset of Osteoporosis by lowering my estrogen so abruptly and drastically. I am a few years removed from my treatment now and I want to stress NOT to use Lupron Depot injections if you fit the profile for high risk of Osteoporosis!! My first 3 injections seemed to provide some relief from pain of Endometriosis, except that some of my adhesions were in my bowel, and it never seemed to help that. I awoke in the middle of the night with excruciating bone and muscle pain after 5th injection (was recommended I have 6) and had to cancel a long-awaited vacation as I could not move! I have 3 ruptured disks, have perforated an ulcer; I have a high pain threshold, but this was incredibly debilitating. And now that I am suffering from fractures from Osteoporosis and unable to work, I am hearing and reading that the Lupron route, for a person with my family profile and physique (small, white female) was a VERY bad idea! The sudden supression of estrogen threw my calcium balance seriously off track and my doctor never knew enough about this drug to know what was happening F 53 5 months
4/24/2006
 5  Large fibroids, anemia, heavy bleed Hot flashes, low energy This drug has given me back my life! For the past 3 years I was bleeding almost everyday. Extrememly heavy periods, couldn't leave the house. I had two blood transfusions - my hemo was down to 4. I am on my 9th monthly shot without add back therapy. It took the first 4 shots to really make a difference. The hot flashes (I call them power surges) are much less annoying than they were in the beginning. My last ultrasound showed a 40% shrinkage in fibroids and uterus. I was afraid to take this drug but so far I am happy with the results. I must mention that I exercise regularly, eat mostly organic and rest when I feel like I need to. F 52 240 days
6/1/2009
 2  Shrink Fibroids, bleeding Pain at injection site briefly, increased frequency & intensity of migraines and acne. My bleeding has not stopped. However, it is not heavy. Don't know about the fibroids yet. I will give it the three months before I say this isn't any good. I chose Lupron to avoid the surgical options which seem like overkill in my situation. The acne isn't that much but having my migraines come more often and be worse is horrible. F 52 30 days
11/6/2008
 2  Heavy Bleeding and fibroid tumors Weight gain, decreased libido, dry mouth, night sweats and hot flashes. The combination of lupron depot, hormones, increased iron and calcium has caused a flare up in psorisis that has been dormant for thirty years. My periods were extremely heavy with clotting. They lasted up to 10 days. My hemoglobin level was almost non-existent. I received my first shot on February 1, 2006 after an intense period. The shot promptly caused spotting for two weeks. Then the cycle from hell started and my blood count went from 7.7 to 6.6 in a matter of days. I almost had to have a blood transfusion. After a regimen of 1000 mg of iron and 1200 mg of calcium, my count is in the normal range, but I have had a constant period since March 9, 2006. I have now had my third shot of lupron depot, on August 2, 2006. Nothing has changed. The backaches and cramps are about on the same scale as having children, and I had 5, all natural. Weight is up, blood count is down and I now have to have a hysterectomy. I've not been pleased at all. The only thing it stopped was the flood every 21 days, now it is just a trickle all day, every day. F 52 6 months
8/15/2006
 1  menorrhaghia x11 months I have been having SEVERE pain in my lower leg, behind the knee, behind the thigh, and in the hip. I've done nothing to irritate any muscles, tendons, ligaments. This pain is almost unbearable. No relief no matter what I do. Doctors just blow it off like it's muscle pain, but I had absolutely NO PROBLEMS except excessive bleeding prior to this shot. I have been to the doctors office three times in 22 days, and still have not gotten any resolution. They know that this is part of the side effects of this medicine. I got the Lupron shot along with a Depot Provera shot, which I was told would offset any side effects from the Lupron; IT DIDN'T. I'm still bleeding like a pig!! Only now, I am in agony because my left leg and hip cannot be relieved even with strong pain meds, muscle relaxants, heat compresses, cold packs, and pillows. I have been having this pain for 18 days with no let up. DO NOT GET THESE SHOTS!!! DO NOT GET THESE SHOTS!! DON'T DO IT!!! F 52
1 shot 1X O
11/23/2010
 1  Prostate Cancer Enlarged Breasts, Night sweats, weakness of the legs, swelling of the legs,loss of balance, weight gain 30 pounds, 5 emergency room visits with heart attack / stroke symtoms, irratable, mood swings Only one, three month injection, a year and a half later I still have problems with my legs, weight, sleep habits, etc. M 52 1 times
7/24/2005
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 1  pre-surgery I had horrific panic attacks and blurry vision in one eye. I only did 2 of the recommended 3 injections. My panic attacks lasted for over 20 years. I have to manage them with Xanax. Do Not Take This Drug. F 52 2 months
1X M
9/29/2019
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 5  Fibroid tumors Hot flahes, weight gain, Not sure about headaches I've always had them, but now I have them in my sleep. Saved my job..changed my schedule at work and I now have to be there. I would have lost my job if I had not received that shot. This is March,12 I had my last period March,11 and I could not move. Bleed for 36 hours straight!! OMG what a nightmare. I had just come off of lupron for the second time. I didn't know I could not stop getting the shot since it says 6 months. Figure it didn't work the 1st time, so i got it again. Behind that nightmare 1 year ago. I have not been w/out the shot until now. Couldn't get it this month and I am having all those horrible symptoms again. I pray missing this month doesn't make me have a cycle again. I love Lupron, whatever the side effects, doesn't compare to the pain, headaches and horrible flow. I also read reviews of Lupron and started not to get it. Even after the 2nd round, I read the reviews again and hesitated.-musta been crazy! I got the shot in 4 6month doses. It helped me soooooo much. Because of all the bad reviews I chose the lower 3.75 dosages, maybe the high dosage makes side effects worse. I wanted to ease into the medicine, to try to feel out side effects and stop if I needed to. F 51 2 years
3.75 1X M
3/30/2012
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