LUPRON DEPOT Reviews (LEUPROLIDE ACETATE)

Average Rating: 3.0 (783 Ratings)

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 ANTERIOR PITUITARY HYPOTHALMIC FUNCTION ANTINEOPLASTICS

 Type: Rx Drug

  

LUPRON DEPOT  (LEUPROLIDE ACETATE):  Leuprolide is used to treat advanced prostate cancer in men. It is not a cure. Most types of prostate cancer need the male hormone testosterone to grow and spread. Leuprolide works by reducing the amount of testosterone that the body makes. This helps slow or stop the growth of cancer cells and helps relieve symptoms such as painful/difficult urination. Talk to your doctor about the risks and benefits of treatment.   FDA Approval Date: 1989-01-26 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on LUPRON DEPOT: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR LUPRON DEPOTCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 3  Prostate Cancer Hot Flashes,some leg pain,some fatigue, some mental fuzziness,increased night urination. Haven't had more than 3 hours of sleep consecutively since injection 3/6 PSA level 29, Gleason 7-10, CAT scan and Bone scan ruled out metastasis. DaVinci Prostatectomy scheduled 6/18. First symptom was leg pain that lasted a few weeks, but went away. Hot flashes are biggest negative. Dr. tried Clonidine, but didn't seem to help. I was very active before the injection (running 10-15 miles/week plus lifting weights). Continue to run and lift weights 4 days a week(with a some loss of endurance and strength, but not bad) Due to increased sweating, I have to make sure my fluid levels are kept up. Changed diet completely, no red meat, a lot of soy, fish,grains,juice. Lost 12 lbs. and feel pretty good. Some days I seem like I can go pretty good, but then hit a wall and am wiped out, but I just go with it and wait until I feel better. Don't know what rating to give the drug, since my PSA won't be tested until after the surgery. I have faith in the course of action my Dr. is taking and hopefully will report back the results. M 61 80 days
5/18/2007
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 1  recurring prostate cancer insomnia leg pain 20 lb weight gain in mid section grew breast testicals shrank memory and cognitive decline head aches unbeliveable fatigue muscle loss hot flashes ears ringing no sex drive very emotional crying suicidal thoughts loose stool six times a day I was not told about the side effects or given anything to read blood pressure went up 20 points also It was like being on a plane about to crash and pilot didnt say brace for impact there was no monitoring during the six months I was on it I would never take again rather die M 61 6 months
? 1X O
3/16/2021
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 5  Prostrate Cancer Constant urge to urinate; Hot Flashes. Hard to sleep and lost of strenght for sex M 60 6 months
11/16/2009
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 5  Prostate Cancer Weight gain (30 lbs, 14% body fat to 24% body fat); inability to lose weight; general decrease in vitality; total inability to get erection; zero motivation for sex; some loss of body hair; tire easily-have to nap every day; discontinued strenous multi-day outdoor activity due to uncertainty about energy level. Up 3-6 times a night to urinate; occasional depression. Cool, huh? I have tried to maintain an aggressive exercise program (weight lifting, biking, some running, spinning class) but my aerobic health and strength levels have continually declined while on Lupron. I feel much older. I feel as if I am continually declining, not making progress to better health. PSA is down to less than .01 after IMRT and Taxotere Chemotherapy (Gleason 9 cancer)so it is working. I have had to begin to turn down invitations to do physically oriented activities due to my level of health. M 60 21 months
4/10/2006
 1  fibroid tumors I feel like my life is over i was 57 yr old when i took this drug,should have done my research first but i didn't. I cant sleep,cant remember anything,depressed so bad i dont want to leave my house,anxiety,mood swing,heart attack,back pain,joint aches,hot flashes,lost sight in both my eyes,every year it something new it doesn't get any better but worst. This drug needs to be taken off the market right now before it destroys anymore lives. I advertise no one to use this poison it's horrible F 60 3 months
30 mg
6/12/2015
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 4  Prostate cancer Injection site pain on occassion. Weakness in hips and lower back so use a weight lifters belt when picking things up. Digestive system problems with gas. Insomnia so take a sleeping pill every night. Wake up from 3 to 6 times per night to urinate. Hot flashes with sweats that I have gotten used to. Absolutely no sex drive or interest-to castrate level for sure. I had a Gleason 6 cancer and underwent 45 IMRT radiation treaments. My PSA was 52.0 and is now down to .7 which shows that this combination was the best for me. Even though I have no sex drive my relationship with my wife has reached a higher level and we spend a lot of time massaging each others back and feet. But since I get up a lot at night we have to sleep in separate rooms. I will be on Lupron for another year and the side effects last from 6 to 9 months after treatment. I won't know if this was the cure until this time passes and we check my PSA. M 59 10 months
6/29/2006
 4  Prostate Cancer Hot flashes, I tire easily with the slightest exertion, weakness, irritability, mood swings, shortness of breath, all of these side effects are continuing still this time though I have been off the lupron for over 3 months second round, first 1 year this time 8 months, the treatment worked both times though the results the second time were not as good as the first. M 59 8 months
1/5/2006
 4  advanced prostate cancer bone mets Fatigue, hot flashes, arthritis, loss of balance, depression, enlarged breasts and weight gain.Still work full time but with a flexible schedule. PSA 0.2 Cancer is stable with no additional metastasis. M 57 2.5 years
7/18/2005
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 4  Prostate cancer Hot flashes, fatigue, loss of strength, loosing body hair, mild depression, irritable Injection every 4 months. As long as it can prolong my life I will continue taking. M 56 18 months
3/26/2004
 3  Prostate cancer Mild mostly, occasional hot flashes, less body hair, less libido. Weight gain around middle, anxiety. Will not know for 6 more months if it has helped. M 56 6 months
12/26/2002
 3  13 cm fibroid I had one injection of Lupron which is suppose to last 3 months. No sex drive. No appetite. Feeling of being numb, ie. no orgasms, no abodominal pain. Severe hot flashes and night sweats. Nights are the worst, every hour and sometimes 4 an hour. Of couse I'm not sleeping because of this and during the day my brain is fuzzy. I can hardly think. Change in taste. I don't want to eat so I lost weight 10 lbs. Depression started before taking the drug and got worse after taking lupron and my depression medication was increased. The increased dosage has had no effect. Sex hurts because of vaginal dryness and vaginitis. Periods have stopped but after sex I spot. Fibroid has shrunk to 8 cm now and all the pressure, abdominal pain,urinary pain, intestinal pain and bloating and heavy bleeding have stopped. I've enjoyed being pain free for 3 months but the drug is wearing off and the pain is slowly starting to come back. Started taking 25 mg of DHEA and depression is almost gone. Hot fla Doctor doesn't want to do hysterectomy because I'm on Coumadin and have had a pulmonary embolectomy and 2 blood clots in my legs so she wants to keep me on Lupron in hopes that my periods will stop soon. I'm 56 and my periods are regular. I'm not sure I want to do another injection. My next appointment is tomorrow and I still don't know what to do. Was it better before? I don't know with all the negative side effects I have now it's hard to say but being pain free for 3 months has been nice. F 56 3 months
1/18/2006
 1  fibroids Extreme mental depressions, up and down emotions. Knee, lower leg and hip pain to the extremes. Headaches and general ill feeling. Nausea, vomiting, constipation and diarreah. Not daily but enough that it was uncomfortable. Weight loss, lack of appetite. I was told that I should take this shot and it would shrink my fibroids and help in excessive bleeding and then I would be able to get robotic surgery. They said after surgery that they couldn't do the surgery with robotics, since the fibroids were too large and there was too many, originally had two, they said ended up with 8. A normal uterus weight about 90 gm, mine was 854 gm, after 3 months of Lupron. With the extreme cost of this shot, I feel it was not worth the pain, suffering and mental anguish! I could have had my hysterectomy three months earlier! And saved alot of money! The lack of bleeding was the only advantage of this shot. Don't do it, if you have excessive fibroids, or you have had them for a extended period of time F 56 3 months
30 mg 1X M
4/24/2010
 4  prostate cancer Hot flashes,weight gain (22#), muscle weakness, swelling in extremities. I work out 5-6 times a week, but have backed off on my running program. The extra weight makes it hard on the feet and legs. Hopefully the treatment will work in conjunction with the cryosurgery in a few months. M 55 5 days
6/28/2004
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 4  prostate cancer My submission earlier showed 5 days. It should be 5 months M 55 5 months
6/28/2004
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 4  prostate cancer impotence, breast tender and swelling, back and leg pains started lupron 3/06 3 weeks before 42 imrt treatments for gleason 7, psa 4.3, t2c, scans negative outside prostate area. i really hope this increases odds of no reacurance, however i don't know if i can take my next shot, the side effects are bad and i can't find any conclusive study/research that proves this extends survival, beyond what occurs with high dose radiation even dr. says it is not showing great increase in ongoing RTOG trials just now ending, but does show small improvement, final data on full 2 years of lupron coming soon. THE GOOD NEWS IS MY PSA HAS BEEN <.1, AND I HAVE TREMENDOUS FAMILY SUPPORT. may GOD bless you all. M 55 17 months
7/15/2007
 3  PROSTAE CANCER I FEEL LIKE I'VE BEEN UP ALL NIGHT, ALL OF THE TIME. I'M MORE IRRATABLE THAN USUAL, AND REALLY FEEL LIKE AN OLD MAN M 55 3 weeks
4/6/2005
 1  severe bleeding,fibroids severe hot flashes, bone thinning, joint pain, palpitations, dry,itchy and crawly skin, melanin changes, mood swings, weight gain, carb cravings, memory loss, hair thinning. (1) 3-month injection reduced the bleeding, but the side effects were debilitating. It's been 3 years since I had the injection and I am still suffering from many of the side effects, most specifically severe hot flashes, weight gain,fuzzy brain F 55 1 months
5/2/2004
 1  prostat cancer hard to uranate or take a dump could not digest food guts were so hard thay hurt hot flashes that just made me teem i hate the stuf i will never take thyat shit again M 55 120 days
11/1/2005
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 1  tiny fibroid I had heavy periods but only a tiny fibroid on the OUTSIDE of my uterus. I had a failed balloon ablation, then they moved to 3 shots of Lupron, that over shrunk my uterus. I ended up having Hashimotos thyroiditis, so I was misdiagnosed. The worst HOT FLASHES x 100 for 6 months, jittery, moody, hormonal rage, over shrunk uterus has remained, 10 years later. I cannot get a pap smear anymore. It shrunk up like a prune. I was told if I start to bleed, even a drop, they will remove my uterus. DO THYROID TESTING. Ruining my uterus was unnecessary, and now I am at a higher risk of uterine cancer! I ended up demanding they TSH TEST! Two OBGYN's missed this completely. One was a specialist. It is a cancer medication and I do not think it should be used for fibroids. (mine was tiny and it was on the outside of my uterus) Being thrown into early menopause because I had Hashimotos, was beyond deviating in the standard of care. Blood tests are not as invasive as balloon oblation and (3) shots of LUPRON. MY OBGYN cannot preform a pap smear on me ANYMORE. She said "it is like cobwebs inside. The walls are all stuck together". Not a cure for Hashimotos thyroiditis by any means! F 55 3 weeks
3X M
7/14/2015
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 4  multifocal breast cancer hot flashes, bone pain, anxiety,very dry skin, dry mouth, dry eyes,injection site inflamation, complete supopression of menstural cycle, difficulty in gait, and a mirad of other symptoms dependent on the time in the shot cycle. The last two shots were the 3 month sort and the symptoms were much worse when compared to the monthly shot. I do not recommend the 11.75 ml shot. Opt for the monthly shot as it is much more tolerable. The doctors do the big shot for convenience...Now I am off the shot my life has returned to a much more normal experience with only slight abdominal symptoms when compared to before the shot. I opted for hormonal intervention rather than the standard chemo offered for my DCIS and invasive breast cancers, stage 2. At 49 I had 2 daughters to raise. Overall it was a better experience than what I witnessed other women go through with chemo. There is no long term heart effects as with Chemo. I recommend this shot on the basis of survival. I wish they had treated me 5 years earlier for the polycystic syndrome, maybe then I could have avoided the cancer assault. Just try to turn it into a chemical Adventure! This shot stopped the terrible menstural syndrom I suffered with for 8 years. 54 3.5 years
7/28/2007
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