LUPRON DEPOT Reviews (LEUPROLIDE ACETATE)

Average Rating: 3.0 (783 Ratings)

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 ANTERIOR PITUITARY HYPOTHALMIC FUNCTION ANTINEOPLASTICS

 Type: Rx Drug

  

LUPRON DEPOT  (LEUPROLIDE ACETATE):  Leuprolide is used to treat advanced prostate cancer in men. It is not a cure. Most types of prostate cancer need the male hormone testosterone to grow and spread. Leuprolide works by reducing the amount of testosterone that the body makes. This helps slow or stop the growth of cancer cells and helps relieve symptoms such as painful/difficult urination. Talk to your doctor about the risks and benefits of treatment.   FDA Approval Date: 1989-01-26 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
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More on LUPRON DEPOT: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR LUPRON DEPOTCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 3  Shrink lrg fibroid/prep for surgery mild hot flashes (not that often) noticed them more after my 4th shot, night sweats and weight gain. Emotions weren't too bad, what I noticed most was that I started getting a short temper, which is not like me. My doctor recommended Lurpon in hopes that it would stop my heavy bleeding (which it did) and shrink my very larger fibroid that was crushing my right fallopian tube, my bladder and growing into the endometrial cavity and other ways. I was told I pretty much had 3 diff types of fibroid in 1 and that it was a little bigger than grapefruit size. I had 4 shots 1x month for 4 months. After reading a lot of comments on here...I thank god that I didn't have that bad of side effects (and am sorry for those that did and had to go through that crap). The side effect that I had the worst was the night sweats and now being that my last shot of Lupron was 2-18-13 I'm not having any side effects except for sometimes light night sweats and I now have an acne break out on my bottom/upper thighs. Not sure if the break out is from the Lurpon or sweat, but the sweating is from the Lupron so I guess technically it is. Anyways, as I said I did not suffer from the side effects too bad, but I don't know about recommending this medicine? I chose to trust my doctor and if it did shrink the fibroid that would make the myomectomy easier and less risk of possible hyst or loss of tube. Overall...my fibroid did NOT shrink at all, but oh well. Fortunately my doctor was able to remove fibroid and keep everything else in tact and after healing should be able to have children! F 26 4 months
1X M
4/6/2013
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 4  Endometriosis Severe migraines usually associated with stress after 1st shot. Loss of period but I'm also taking pill form birth control continuously (no sugar pills). Moderate fatigue after 2nd shot. Acne on my back, chest, and arms after 5th shot. Mood swings (going from crying to absolute euphoria) after first shot. Joint pain on and off starting from the 3rd shot usually localized in knees and wrists. I have had no weight gain or loss but I am also very active (running and lifting weights everyday) and eat very healthy which is suppose to help. Before Lupron I could hardly excesise at all some days because of sever pain associated with endometriosis and when I was on my period I couldn't get out of bed most days. Now I have absolutely no pain. All my symptoms seem minuscule compared to the benifits. It may be frustrating at times but compared to how I use to be I'll be ok with dealing. F 19 1 years
3/13/2013
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 4  Endometriosis & Fibroids - Head Ache (severe) - Unstable Emotions (accelerates any minor mental illness into a major illness) - Insomnia (Extremely severe multiple days without sleep) - Heavy Period - Dr communicated it would last three months to shed uterine lining. - Loss of appetite - Hot Flashes - Chills -Random Sweats (All hours of the day) -Lower body temperature (random) Doctors often do not disclose all of the symptoms, because they believe in the medicine. My doctor told me I would have hot flashes at night and heavy periods for the first three injections. He never told me about chills, insomnia and etc. The insomnia is the worst part of the injections, because you don't just have trouble falling asleep you have trouble sleeping. If you fall asleep for more than two or three hours on this medicine you are very lucky! F 34 6 weeks
3.75 MG 1X M
2/11/2013
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 3  Shrink fibroids before surgery Severe muscle and joint ache. Loss of concentration, moodiness,jittery,and mild depression, headache. Feels like a severe case of the flu. Period never stopped but did slow down. Was scheduled for 3 shots but I can only take 2. Too painful. It hurts to open my car door. I hope this wears off soon.Although it feels like the fibroids are smaller. F 45 2 months
1X M
2/11/2013
 2  uterine fibroids I'm not on the drug lupron as yet but scared up to my neck about the side effect and what happen to ppl after stop lupron years down the line. My Dr want to start Mr on lupron to shrink and remove my fibroids so me and my husband can conceived, I'm worried about all those dreaded side effects during and after lupron I'm so depressed I don't know what to do. Someone plz help me. F 35 6 months
7.75mg
12/5/2012
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 3  Endometriosis At first I was taking one shot a month and I experienced the worse! Extreme fatigue (still have) severe migraines, crazy night sweats, hot flashes sweat was literally pouring down! I also take hormone pills to calm down the side effects. I lost 7lbs on the month to month. Now I am on the higher dosage taken once every three months. Good thing I no longer get the horrible periods and heavy bleeding that just completely stopped. Now it's more so dry mouth vision problems, I'm extremely extremely tired I'm constantly calling out of work because I have no energy. I've gained my 7lbs back appetite is extremely large I eat so much! Honestly I feel preggo and I don't even know what that feels like! Just can't wait til this therapy is complete don't wanna lose my job! F 27 6 months
1 every 3
11/28/2012
 1  shrink fibroids before surgery Hot flashes, mood swings, depression, joint pain, back pain,insomnia, anxiety, high blood pressure, thyroid problems,&short term memory loss F 38 1 days
11/20/2012
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 3  Endometriosis and PCOS Weight loss (about 6 lbs in a week), no appetite, mood swings, cramps, constipation, nausea It hasn't been as bad as I thought it could be. Two days of horrible cramping and a week of bleeding. It stopped and now I am dealing with nausea (like I ate something bad and want to throw up, but I don't) and no appetite. I am on anti-nausea pills three times a day, and they help me enough to be able to eat when I remember to. The weight loss is because I just felt unable to eat because of the nausea and going off birth control I'm pretty sure. I weighed 119 and I'm 5'4, and now I'm 113. So kinda scary to lose all that weight in a week, I thought for sure I would gain weight, not lose. The first two weeks I was insane and cried over everything. Now I'm just mostly having headaches and nausea. I have noticed a decrease in my level of pain however. I just started the addback, hopefully when I start having hot flashes they won't be as bad. I upped my water intake tremendously and it has helped A LOT. I drink juice whenever I can't eat, and it ups my calorie content and helps the constipation. I would exercise, but I'm afraid to because I'm so calorie deficient right now. It's not all that bad so far. F 20 3 weeks
3.75 1X M
10/2/2012
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 3  endometriosis fatigue, 20lb weight gain, tiredness, memory loss, bloated,vision changes, leg pain, abdominal pain, depression, very angry at times, hot flashes, sweats, On my 6 th shot and just want to cry thinking about it. My doctor wants me to try another month but I will give my self an injection once daily because the side effects were so bad he decided that one doce at a time was to strong for me. I don't even want another shot but I just don't want to go back to having so much pain!! I have gained 4 lbs in one week, is this crazy even the doctor witnessed this because I was there for one shot and my anual appt and then I became sick with other symptoms now and he weighed me and said wow you did gain 4lbs in one week. I now have been experiencing stomach pain, very bloated, in 2 weeks I went up 2 sizes. Awful feeling I just want to cry. I will be going for more tests tomorrow and something tells me that I am gonna tell him to schedule me for a hystorectom because I just can't deal anymore. I am 45, thank god I have twins. F 45 5 days
3 1X M
9/27/2012
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 2  Endometriosis Lupron depot shot Im on my third month. Side effects are very severe thus far and are getting worse. Im 25, Im experiencing severe hot flashes, mood swings, sleepless nights, cold sweats at night, rashes on my belly, acne, loss of appetite, head aches...very very severe head aches and now the loss of all moisture in my entire body! vaginal dryness is like nothing Ive ever experienced :( along with yeast infections on and off. Pain in the knees, blurred vision, tired all the time... Will not be doing my next 3 month shot. Id rather be dead! Research this and seek alternative care! do not do this unless it is life or death... F 25 3 months
3X M
9/11/2012
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 1  Adenemyosis Migraine Headaches, hot flashes, cold flashes, night sweats, an increase of pain for the first three months, forgetfulness, severe mood swings (yelling to crying to blissful), depression, right leg twitchiness, decreased sex drive and vaginal dryness. After the following shots: 1st- severe increase of pelvic pain, heavier bleeding, migraines, joint pain. 2nd- still had pain, forgetful, bleeding stopped, migraines got worse and my skin and eyes became extremely sensitive to sun. Hot flashes galore and IBS has become a way of life at this point. 3rd- pain started to get better. Hot flashes were like nothing I had ever experienced. Then I started to become an emotional roller coaster. Joint pain went away. Got a lot of acne on face and back, skin started peeling when I'd use acne mess so I stopped. 4th- pain was gone! :) medical menopause is horrible. Depressed all the time, and hated my life. 5th- gained 4 pounds, my feet are swollen (I have kankles) gross. Hot flashes and major night sweats. There are times I have to get up to change the sheets. I get cold flashes also where it feels like I'm freezing even when it's 90 degrees outside. I sweat all the time and my deodorant just isn't cutting it. Acne is worse than ever! My hair falls out by the bunch and I can't wait to be done. 6th- just scheduled for a hysterectomy. Tubes, cervix, and uterus will be gone in five days. Still abnormally sweating and I'm so embarrassed. My hair is getting thinner although I don't understand why. Acne is extremely noticeable and has been for some time. I take sometimes two showers a day and I hate lupron. Headaches and bouts of IBS flares (constipation and diaherra) are everyday now. My husband hates the mood swings. Almost feels like F 25 6 months
3.75 1X M
9/9/2012
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 1  Fibroids Muscles and joints ache nonstop all the time.. hot flashes. Hurts to get out of bed, from seated position.. not as flexible as I used to be.. hurts to walk.. I'm in constant pain F 37 3 times
8/1/2012
 1  Endometriosis Mood swing, fatigue, headache, panic attacks, eventually develop seizures and epilepsy. TERRIBLE DRUG and HORRIBLE side-effects. Took Lupron in 2008-2009 for 12 months. Since then, have had bad episodes of panic attacks and seizures. I am suffering from epilepsy now because LUPRON messed up my hormone so badly during the year I was treated. I WISH my OB never put me on it. It didn't even control the endometriosis as I still had to go through a 6 hours surgery to take care of the problem anyway. F 37 12 months
1 Shot 1X M
7/31/2012
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 1  Endometriosis. Headaches. Fatigues. Difficulties w breathing. Mood swing. Multiple seizures and ended up with epilepsy. :( F 33 10 months
7/29/2012
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 1  deep tissue endometriosis Tremendous weight gain, hot flashes, bone burning, joint and muscle pain, loss of eye lashes, some hair fell out, couldn't stay asleep, memory loss, thyroid issues, throat issues. I did 9 shots of lupron every four weeks. I am now about 2 years from my last shot and still have horrible side effects. Bone and joint pain is still horrible, I still can't sleep, and my eye lashes still won't grow back. Despite several RX weight loss pills, I have not lost any weight. Once active, I now just lay around all day because my entire body just hurts too much. F 23 9 months
1X M
7/5/2012
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 1  PMDD Blurred vision, major hip pain, left leg pain. I feel like an 80 yr old woman. Major fatigue, It's very difficult to get out of bed in the morning. Stiffness and achy hands and fingers. Tingling sensation in hands. Short term memory loss. Loss of Vocabulary. It alleviated my PMDD symptoms, but now I have major physical issues. Don't take this poison! F 42 18 months
1X day
7/1/2012
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 4   Pain in the leg, night sweats, head aches and forget a lot but urge wise the mensuration its better.I can live without it I user to be in do much pain til I cry and goes to the E R for pain releave I think the shot is a must and it helping shrink the fibroids .I've had no serious side effect and taking my second does yesterday it was different from the first one only differs its my left leg us very sore. 6 months
6/27/2012
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 5  Endometriosis NIght sweats, hot flashes, vaginal dryness, forgetfulness OK ladies this is my second time taking Lupron within 3 years. After my surgery to remove a ovarian tumor in October 2009 when I went to my post-op appointment is when I was told that I have Endometriosis. I started Lupron right away. The pain was instantly gone and so were my periods. Life was great! Then in September 2011 I went for my annual pap and was discussing with my new GYN that I wanted to get pregnant. I had been preiviosly married for 14 years and never once did I get pregnant. Now I know for sure that the problem was me (my ex cheated and got her pregnant). Now I'm engaged to my childhood friend who is my soulmate and now I want to have a baby with him. So after I had an ultrasound done it was confirmed that I did have another cyst and that he wanted to see how bad my endo was now.(I had pics from my previous surgery). Once my new GYN saw the pics he said he could only imagine how bad it would be since the pics were over 2 years old. Long story short I had surgery in December 2011. all went well. My Endometriosis was like a spider web covering all my reproductive organs. My doctor was sucessful in removing it. Unfortunately I lost my left tube because it is completely blocked and my uterus was attached to my abdominal wall. He detached my uterus and left it in. I am going for my final shot in this round tomorrow. this will be number 12 that I've taken since 2009.Next friday 6/29/12 I will be discussing what my next step will be to try to become pregnant. I know F 35 6 months
3.75 1X M
6/21/2012
 3  Catamenial Pneumothorax-Endo Headaches, hot flashes, severe mood swings, crying spells, breast tenderness, dry skin, thinning hair, abdominal pain, weight fluctuation, irritability and suicidal thoughts. I have endometriosis and by some pathway in the body, the cells travels and attaches to my lung. There it stays. During my cycle, those cells will menstruate, and at times, tear the lung wall and cause a hole, therefore a collapse will occur. Now, I have no cycles, and no more lung collapses. Although, it is working, the seriousness of this drug scares me. You have horrible physical and MENTAL side effecrs. It has affected my job, my relationship with my boyfriend, my family and my friends. My doctor wants me to go another year! I don't know if I can do that, not sure my body can handle. I wish there was another alternative to treating this disease. This drug should not be available, this way we can push for more aggresive research, to help solve the enigma. F 34 1 years
3.25 MG 1X M
6/21/2012
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 4  Heavy mentral lasting 8-12days Hot flashes, night sweats, mild cramping, headaches. In the 1st 2 shots I felt like I had pregnancy symptoms. Nausea at the smell of most foods, tender breasts, &vertigo. However, the shots have been so worth it. I had one period on the first shot, but none since. I stll feel cramping as if im ovulating and it can be extreme pain. Slight weight gain... 4lbs. I would highly recommend this treatment so far. I was misserable on my periods. F 32 4 months
5/26/2012

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