LUPRON DEPOT Reviews (LEUPROLIDE ACETATE)Average Rating: 3.0 (783 Ratings)Filter ResultsCompare LUPRON DEPOT with similar:
Type: Rx Drug
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More on LUPRON DEPOT: Reviews Summary | Drug Safety Information
| RATING | REASON | SIDE EFFECTS FOR LUPRON DEPOT | COMMENTS | SEX | AGE | DURATION/ DOSAGE | DATE ADDED |
| 5 | prostate cancer | I seem to be the poster patient for this medication. Hot flashes,(mild)weight gain (10-15 lbs.)pretty close to zero sex drive,slight breast enlargement( weight lifters chest)loss of body hair, (especially on legs where clothing rubs)mild loss of energy ( from a type A to a type B or C) which feels pretty good to be able to relax and not feel guilty about it. | After radical surgery. Thirty-nine radiation treatments and up and down PSA readings over the past seven + years it feels good to have a PSA of <0.01.How long it lasts we will see,but it feels pretty good for now. I have had two ,three mo. shots. I am off now for six months or until my PSA starts rising.The side effects are mild compared to the alternative. Now that I have been off it for a month some things are getting back to some semblance of normal. | M | 62 | 6 months | 2/5/2006 | 5 | Prostate Cancer | Hair loss from legs, arms, chest, Hot flashes, Middle weight gain, Reduced enegery level, Tired feeling a lot of the time,Loss of sex drive, Loss of sex intrest, Headaches, A lot of heavy phlegm. | I was diagnosed with Prostate cancer at age 67. I had a PSA every 6 months for 15 years. In Jan of 2002 the good PSA was 24 and the bad PSA was 3.5. The bad had been runnning from 3-4 for 3 years. In June of 2002 the good PSA was 18 and the bad PSA was 4.75. At that point the Urologist scheduled a Biopsy and the cancer was found in 4 of 5 samples. I was lucky sometines it is missed. My "Gleason" number was 8.5. I received the first 4 month Lupron shot in February 2002 to try to stop the cancer and shrink the Prostate. I underwent radical Prostate surgery in April 2002 and there were no cancer cells outside of the Prostate. They checked Lymph nodes and they were clear. Because of the high "Gleason" number I stayed on 4 month Lupron shots, receiving the last one in June 2006. My PSA has been lower than they can read since the surgery. It is now <.04. I took Megace "Megestrol" from June 2002 untill April 2006 for the Hot Flashes, it controlled them. Before | M | 71 | 3 years | 6/22/2006 | 5 | prostate cancer | Hot flashes, enlarged breasts, decrease in energy level | Have had PCa for 8 years; 2 reoccurences after radiation and thermal therapy PSA dropped to 0.12 Seems to be under control with lupron depot.I hope it continues. I have a friend who has been on it for 5 years. PSA is still undetectable. Original PSA was 92 with originally a T2B and a 7 Gleason. Reoccurence after radiation, went directly to Lupron.Age 66. I am optimistic this will buy me more time but realize eventually this becomes refractive as the body gets used to the drug | M | 66 | 1 years | 12/18/2005 | 5 | Prostate Cancer | Weight gain (30 lbs, 14% body fat to 24% body fat); inability to lose weight; general decrease in vitality; total inability to get erection; zero motivation for sex; some loss of body hair; tire easily-have to nap every day; discontinued strenous multi-day outdoor activity due to uncertainty about energy level. Up 3-6 times a night to urinate; occasional depression. Cool, huh? | I have tried to maintain an aggressive exercise program (weight lifting, biking, some running, spinning class) but my aerobic health and strength levels have continually declined while on Lupron. I feel much older. I feel as if I am continually declining, not making progress to better health. PSA is down to less than .01 after IMRT and Taxotere Chemotherapy (Gleason 9 cancer)so it is working. I have had to begin to turn down invitations to do physically oriented activities due to my level of health. | M | 60 | 21 months | 4/10/2006 | 5 | PROSTATE CANCER | HOT FLASHES | PSA IS .01 AND LUPRON INJECTIONS HAVE BEEN VERY SUCCESSFUL! | M | 69 | 14 years | 8/21/2007 | 5 | prostate cancer | Loss of libido. Diminished size of testicles. No hot flashes. No weight gain. No muscle weakness. Continued all excercise regimins of resistance and biking and started swimming lessons at 4 months into Lupron. I even increased the weights on resistance machines. | After reading the comments of others, I was dreading starting Lupron/Depot but other than the two listed side effects, my life has continued exactly as before including all exercise programs which average about an hour a day. Also had 38 radiation treatments on Varian Associates Trilogy machine during this time. | M | 80 | 5 days | 5/2/2007 | 5 | prostate cancer | my last rating recorded 5 days and it has been 5 months since I started Lupron | M | 80 | 5 months | 5/2/2007 | 5 | Prostate Cancer | My primary side effect is hot flashes. I may be experiencing some extra tiredness, but hard to tell if it is age or Lupron. My prostate and everything associated was removed, February 2006, so I knew my sex life would be over. Small amount of cancer, about one gram, still in my system. | I am on intermitent therapy. I take a monthly shot, 7.5 mg., until my PSA is less than .1 for two months. Therapy then stops until my PSA goes up for two bi-monthly tests. I continue to be active physically riding an excercise bike and lifting weights almost every day. I also play tennis once or twice a week. I have lost about 10 lbs. in the last year as I have also watched my diet, primarilly less red meat. I return to M.D. Anderson annually for a check up. Just had first annual check up and considered in excellant shape. | M | 69 | 12 months | 7/12/2007 | 5 | prostate cancer | Tiredness and bowel problems but this may be due to old age. | PSA reading shot up to high twenties and an operation was considered but I chose the Lupron injection treatment every 3 months. 'Something else will probably kill you first' was one bit of advice. My latest PSA reading was under 2 so I am pleased with the results so far. | M | 81 | 2 years | 7/24/2009 | 5 | Prostrate Cancer | Constant urge to urinate; Hot Flashes. Hard to sleep and lost of strenght for sex | M | 60 | 6 months | 11/16/2009 | 4 | ProstateCancer | Hot Flashes. Total loss of libido. Unable to get eractions | Been on Lupron for 5 months. Second shot hurt so bad could hardly walk for 3 days. PSA went from 38 down to 2.4 so it is working. Going to go intermittent to give body a chance to recover. Trying to keep from surgery/radiation if possible. | M | 79 | 5 months | 12/23/2009 | 4 | Endometriosis | Occasional night sweats, weight gain | This is my 6th month on this medication. I get a shot every 3 months. I had surgery to remove my right ovary and fallopian tube due to cysts and endometrioma. My OB-GYN put me on this drug so I will be on temporary menopause and hopefully help with keeping the endo at bay. Don't get scared to try this med, each patient will react differently. Fortunately, I did not experience all the side effects that affected others. The worst side effect for me is the weight gain. But hopefully, I will lose it when I stop with the treatment. | M | 46 | 6 months | 10/1/2008 | 4 | Prostate Cancer | It's been 6 weeks since I was injected with 22.5 mg Lupron to reduce the size of my prostate. My prostate needs to become smaller so that I can have seed implants. So far I have not had any adverse effects. Insomnia was a problem I had prior to the Lupron so I can't attribute the drug to that problem. Wheter the drug is working or not will be determined in about 7 weeks when the volume check will be done. | Nothing more to say except, I was expecting all the side effects, but after 5 weeks, can't say that I have experienced any.I will continue to keep my fingers crossed. One other thing. I saw how much my health insurance company was billed for the shot and understand now why the health business in this country is going to collapse soon unless something is done. $3433.00 | M | 35 days | 5/27/2009 | 4 | prostate cancer, bone metastasis | Osteoporosis, hot flashes, skin reaction (Eczyma), sex change: (impotence, grow belly and breasts, atrophy elsewhere) | Sommer 2007: Severe back pain. Prostate cancer was discovered, PSA over 500. It was in by bones, the fouth vertebrae. 11 radiations got rid of pain, but was too strong, closed my troat, could not speak, could not eat, lost 20 lbs in a week, almost died (got bill anyway), Recovered. (doctors prescribed mouth wash, did not help, my wife broke up Aloe Vera jells and fed them down my thoat, it gradually opened my throat). Since then getting LUPRON DEPOT injections first monthly, then every 3-4 months. PSA December 2008=0.85. Great. But side effects are bothersome. Will suggest skipping one injection, to see what PSA does. Only if it goes up again will I ask for another injection. Also will do another bone density test, which will show the osteoporosis or not. maybe I beat the cancer yet. | M | 83 | 15 months | 12/9/2008 | 4 | metastacised prostate cancer | Man boobs --- joint pain --- fatigue --- hot flashes | Started in May of 2022 after diagnosed with Stage 4 cancer. PSA @ 760. Given 6mos to live without treatment. Eligard brought PSA down to below 1.0 within 60 days (now at .2). Other than the listed side effects (which are somewhat tolerable), this drug has helped me thus far. May quit if quality of life decreases (in other words, if side effects get worse). It has given me time to get my affairs in order. God Bless All Who Are Going Through Similar Circumstances! | M | 72 | 10 months 1X O | 2/11/2023 | 4 | prostate cancer stage 4 | The most disturbing side effect has been that Lupron has caused inflammation(feels like heart burn) in my stomach and small bowels. As a result I want to soothe the burning by eating all the time. My waist size has gone up two inches and my weight by twenty pounds over the period of a year. The standard medication of heart burn (tums, zantac, etc.) does help to ease the burning in my stomach but not in the small bowels. | Lupron has lowered my PSA to 0.0 and effectively supressed any libido which at my age (76) is something I can live with. I would be an enthusiastic user but for the heartburn and weight gain. | M | 76 | 12 months | 7/18/2007 | 4 | Prostate Cancer | Slight anemia, probable aggravation of conditions either already existing or oncoming: high blood sugar, low energy, restlessness, lack of libido, increasing irritability, decreasing body hair, skin reverting to baby-like smoothness. | Works for me: TRUS and biopsy showed cancerous or precancerous cells throughout 2/3 of prostate that was 11 times normal size; PSA 6.8, Gleason 7. After two 3-month Lurpon injections and one month on Casodex, prostate was half as large but still twice operable size; PSA <.4. Main gripe is damn surgeon didn't speak one word to possible side effects; just a faint smile when I bring yet another symptom to his attention. Started out with a few strikes against me anyway: bi-polar with panic-anxiety disorder and hugely overweight, heavy drinker for years. Meds, age and bad habits have brought on adult-onset diabetes which I am now sure is aggravated by Lupron. Before all this, however, am sure I underwent "male menopause" at precisely age 40: loss of energy and interest in formerly enjoyable pursuits including sex, raging night sweats for several years with highly disrupted sleep. Got past all that, so Lupron had noplace to go except straight to now-shrunken gonads and prost | M | 61 | 17 months | 2/2/2008 | 4 | prostate cancer | impotence, breast tender and swelling, back and leg pains | started lupron 3/06 3 weeks before 42 imrt treatments for gleason 7, psa 4.3, t2c, scans negative outside prostate area. i really hope this increases odds of no reacurance, however i don't know if i can take my next shot, the side effects are bad and i can't find any conclusive study/research that proves this extends survival, beyond what occurs with high dose radiation even dr. says it is not showing great increase in ongoing RTOG trials just now ending, but does show small improvement, final data on full 2 years of lupron coming soon. THE GOOD NEWS IS MY PSA HAS BEEN <.1, AND I HAVE TREMENDOUS FAMILY SUPPORT. may GOD bless you all. | M | 55 | 17 months | 7/15/2007 | 4 | Large Uterine fibroid- pidaua | I have been on Lupron now for 2 weeks. I posted earlier (see under pidaua) and the only other side effect I can add was another period that began 7 days after the first injection. It lasted only 5 days but was heavier than normal. I felt wiped out, but that may be due to lack of sleep because of the stress of my husband being in Iraq. | I have to encourage people to take their vitamin supplements and get exercise even if you don't feel up to it. Yoga and lots of walks have helped me tremendously. My lower abdomen does not feel full and my body is getting back to the shape it was in before the large protrusion caused by the fibroid. I believe that those with fibroids have an easier time that those with endometriosis. Then again, there will always be some that complain about any medicine under the planet because they are against pharmaceutical companies. Be informed. | M | 37 | 2 weeks | 5/8/2007 | 4 | Prostate cancer | Fatigue, irratibility, insomnia, swelling in hands and feet, weight gain of 20 pounds, some depression, lack of sex drive, tingling and itching in extremities, occasional night sweats. | I am on the second of a scheduled 3 injections. Had IMRT treatment for PC. PSA went from 9.9 to .01. Lupron side effects are hard to take, but if it does the job, I can take it. | M | 62 | 6 months | 6/11/2005 |
LUPRON DEPOT (LEUPROLIDE ACETATE): Leuprolide is used to treat advanced prostate cancer in men. It is not a cure. Most types of prostate cancer need the male hormone testosterone to grow and spread. Leuprolide works by reducing the amount of testosterone that the body makes. This helps slow or stop the growth of cancer cells and helps relieve symptoms such as painful/difficult urination. Talk to your doctor about the risks and benefits of treatment. FDA Approval Date: 1989-01-26 (Sources: U.S. Centers for Medicare Services, FDA)