LUPRON Reviews (LEUPROLIDE ACETATE)

Average Rating: 2.7 (853 Ratings)

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 DRUGS USED IN DISORDERS OF GROWTH HORMO HORMONAL BIOLOGICAL RESPONSE MODIFIERS

 Type: Rx Drug

  

LUPRON  (LEUPROLIDE ACETATE):  Leuprolide is used to stop early puberty (precocious puberty) in children. It helps to delay sexual development (such as growth of the breasts/testicles) and the start of menstrual periods. It also helps slow down early bone growth to increase the likelihood of reaching normal adult height. Leuprolide works by decreasing the amount of sex hormones that a child's body makes (estrogen in girls, testosterone in boys).   FDA Approval Date: 1985-04-09 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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RATING  REASONSIDE EFFECTS FOR LUPRONCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  prostate cancer spread to bones My father had three injections and became very fatigues and depressed. He took his life a month and half after the last injection of Lupron. He had a heart condition also and was given the drug anyway. It has been shown to cause cardiac arrest. THe nurse practioner at Thomas Jefferson Urology in Philadelphia, PA said she saw my father was depressed and she continued to give him the injections. She was not supervised by an MD which is permitted in Pennsylvania. Before the shots, father was walking around Philly. After he was too tired and depressed to do anything. Nurse also gave him Casodex which combined with Lupron severely lowers testosterone levels. Dr. Sui-Long Yao of Cancer Institute of New Jersey did a study that shows Lupron doesn't increase lives of prostate cancer people and seriously damages the quality of their lives. The Los Angeles Times newspaper reported those receiving Lupron had a 17.4 percent death rate vs. those not receiving it of a 19.9 percent death rat all of his teeth would have to be pulled because Zometa causes decay of the jaw bone. She said my father didn't want that to happen to him and she didn't refer my father to anyone else for chemotherapy when he asked if there was another course of treatment. She let him leave very depressed and tired from the Lupron and Casodex. The supervising doctor, Dr Goldman, of the nurse practioner, nurse Darlene Bewick,said to me he didn't know about my father's care because the nurse saw him. he didn't even know my Dad had bone cancer from the prostate. Do not take Lupron. It causes severe damages and has caused my father's death. Doctors keep giving the drug. Please email me: Cheryl. M 88 4 months
11/8/2009
Email
 1  Advanced Prostate Cancer Extreme fatigue unable to get energy to walk halfway across yard. Extreme depression. Effecting hands, almost useless He has been taking shots for about 1 1/2 years symptoms are now extreme. Saw Dr. And said no more asked if he could get Tester one even if it makes the cancer metastise. Dr said he could not, he has to wait until it wears off. His shot 2 months ago was a 4 month shot, the last one took 8 months before it wore off. I am afraid he will not be able to mentally survive. He would rather enjoy a shorter life, then live miserably. M 86 18 days
4 month sh
5/8/2017
 5  prostate cancer, radical prostate ED, frequent urination, weight gain, joint pain, cellulitis. M 81 12 years
25MG 1X AN
6/26/2017
 1  Prostate cancer Every single complaint previously listed by other males on this list. Total lack of interest in sex,(which I enjoyed very much despite my age),sweats, aching joints, change in skin texture, lack of interest in most endeavors. In addition, I have had a radical change in bowel movements, headaches when I have NEVER had headaches before, and seem to have little or no initiative or 'get up and get something done' attitude. I've also had trouble with hemmorhoids, which I have not had since my late teens, early twenties, and then only minor. Now most annoying. I have not had opportunity yet to determine whether Lupron will actually reduce my PSA numbers or not as I must wait for my next appointment with my Urologist to take PSA. Even if it does, I would hesitate to agree to being injected with Lupron again. It is, as one gentleman said, "Like being castrated".. I would add a big PLUS to that! M 81 2 months
8/17/2007
 4  Prostate Cancer hot flashes, chills, joint pain, insomnia, swelling of the ankles,testicle pain, impotence. I always had a high PSA level since 40 yrs old, 5 biopsies, all but the last negative. My oncologist said I had a lump on my prostate, negative biopsy 12 mo prior. Biopsy showed some Gleason 9 samples, serious cancer. Tests showed that the cancer had not spread. Lupron and 45 radiation treatments recommended. Lupron once every 6 months. 1st shot few side effects until the 5th mo when I had many hot flashes. Lupron did reduce my PSA to zero after 1st shot and still zero after 2nd shot. Testosterone at 17. So lupron doing what it is supposed to do. After the second shot several other side effects began with testicle pain being the worst, a dull ache, and wishing for an orchiectomy. Pain mostly gone after about 3 weeks. With the 2nd shot the Dr prescribed clonidine for hot flashes, which also has a side effect of testicle pain not mentioned by dr. Stopped taking clonidine after 3 days. Lupron also made me feel like I was 80 with joint aches and pain, but I was also doing some manual labor that may have caused some of the aches and pain. I do a 16 mile bike ride once a week, most weeks depending on the weather. I also have chills usually before a hot flash and some swelling of the ankles. No sexual desire anymore, but that was gone due to other medication before lupron. I was told to take 1000 units of calcium with 400 units of vitamin D to counter bone loss. The calcium caused some hard stools, so now I take an over the counter stool softener without a laxative. M 80 11 months
unk 1X O
12/27/2017
Email
 1  Prostate Cancer Dangerously high blood pressure and excrutiating joint pain in my left foot. I was 79 when diagnosed with prostate cancer and was treated at a world renown clinic. I was given a 1-month injection followed by a 4-month injection. About two weeks after the 4-month injection all hell broke loose. I had frequent blood pressure readings in the 200+/100+ range, sending me to the OR three times in three weeks. My BP med was doubled and another added before my BP was brought down to 140-150 over 80's range. The pain in my left toe joints was so severe I had pretty much decided that if the pain didn't diminish as the drug wore off I would need to have my toes amputated.I was never warned of these side effects.In fact, I could never convince the oncologist at the clinic that these problems were Lupron induced. He kept repeating that in 80 patients none had complained of these problems. Thank God that the pain and BP problems abated as the drug wore off, M 80 5 months
9/25/2008
 3  Prostate Glesson score 7 Minimal hot flash symptoms--some dizzy moments and shortness of breath it is too early to tell so my giving a rating is way too premature... M 79 5 months
40MG?
8/23/2014
 3  prostate cancer Hot flashes, sweating, total loss of sexual desire, fatigue. Taking Lupron to shrink prostate in order to receive seed implants. Hot flashes are annoying, but tolerable. Fatigue just causes me to slow down some. Loss of sex desire not a problem. I exercise regularly and walk a lot, which I believe reduces side effects. After 4 months of Lupron (plus a daily dose of Casodex pills), I hope to be ready for the implants. M 79 2 days
9/3/2007
 1  Gleason of 6......PSA 5 ?????? Hot Flashes..Shoulders and hips ache..Weight gain...Slow urination...Can't sleep without (Zanax) sleeping pills...Up every 2 hours urinating...Its been a 5 weeks since I got shot..and 4 week since seed implants....They treated me with 2 different Cancer treatments for very small amount of cancer.... I have all kinds of problems now.. Live in Il.... In Florida for winter..Went to Highly Refered Doc in Fort Myers...After Biopsy had one of 14 Positive for Cancer...Got seed implanted..But a week Before Seeding...Dr gave me a 6 Month Lupron Shot??? I have no idea why.....I should have looked into it before...To late now..Making me Miserable...That shot is for advanced prostate cancer Patients..I wonder if he treated the wrong patient in the wrong room.....Would never advise anyone to get that shot unless it was the last resort...For advanced Prostate Cancer...I think Dr.Screwed me up... M 77 5 weeks
12/29/2007
Email
 5  Prostate cancer after radiation Hot flashes, slight decrease of energy, zero libido, slight weight gain, forgetful, M 74 1 years
?
3/21/2020
 1  prostate cancer Where do i start,anxiety,depression,huge around middle, tinnitus, muscle and joint aches, high cholesterol, lethargy so tired,nasal congestion, headaches, changes in taste and smell.shrunken nuts, no sex for 4 years, boobs with lumps in. This stuff can change your life, you will want your old self back. Some men it works without side effects great for them,but it is not a one size fits all drug,as many on here know to their cost. I love life but lupron takes all joy out of it.Yes it lowers psa and hopefully keeps you alive,but i did not expect so many side effects and after being off the stuff for more than 2years i do not think things will get better.It does not seem to me that lupron ever leaves your system,it remains in some way. The bottom line is if you have no choice take it,but take as little as you can to remain who you are and stay alive.This is just my opinion on my experience on lupron, get the full facts for yourself on lupron if you find yourself being told you need it, I hope that you do not. M 74 18 months
11.25 1X O
8/29/2020
 1  Prostate cancer Hot flashes. Mind fog. Dizziness. Fatigue. Hot burning skin. Mood swings. Anemia. This stuff sucks. Will never take it again. M 74 5 months
7.5 mg 1X M
3/20/2022
 5  PC that went to my pelvis bone all the mentioned side effects. had Prostrate surgery....in 92....went free of PC for 12 yrs came back slowly rising to 17........over 4 yrs. Took lupron 7 months PSA then dropped to .04.....went into remission.....went 18 months no treatment....came back up to 17 then i started again...after 4 months its 2.0.........IT WORKS !!!!! our plan is to use lupron to put it in remission, when PSA rises to 17 again start lupron.....my doc says he knows men that have done this for 18 yrs. I believe their are docs out there that way over treat for the fees.....YES, i do . Especially if you have good insurance. Sounds like some of the men on here have been subject to that...iam no doc but all those different treatments when your PSA is in normal range sounds fishy to me.i wouldnt do it.we have to be informed and question these docs. M 73
1X day
6/5/2011
Email
 3  Total Androgen Suppression Minor hot flashes, zero sexual response, shortening of member. I have not had post-IMRI PSA test yet. While I am aware that many men have disabling side affects, I have not found that to be true (yet) in my case. I had my second four-month injection about two months ago. The lack of libido I find satisfying as it has released me to concentrate on other matters that are important to me. While I suggested to my wife that I was ready to discontinue it, for her sake, she has asked me to continue to receive it for the two years recommended. The shortening of the member is significant (all of a sudden I have a foreskin problem that did not exist before) but I will have to wait and see if it is disabling in any way. All in all I consider myself very lucky in experiencing a minimum of side affects and am leading a successful, meaningful life. M 73 6 months
8/30/2007
 1  Prostate cancer surgery Hot flashes always fatigued Was a high level competitive cyclist now can only ride at a low level 2x per week havent been able to even cycle with friends as too slow constant joint pain legs and hands cant sleep more than 2hrs even with meds I wasnt told different dosage shots available never consented but got a 6 month shot and Im in 23 weeks and its worse than ever when wills effects start to go away? I got a supposed 6 month injection but feel worse than ever Depressed as doesnt seem this will wear off The Dr only said night sweats what crap Will I ever be normal again ? After research I find they dont know how this drug is metabolized- how did it ever get thru the FDA? M 73 6 months
45mg 1X O
12/23/2020
 1  Stage 4 prostate cancer Hot flashes , pelvis testicular pain. Fatigue,depression, no sex drive , E D No sleep. Loss of muscle mass Weight gain Ruined who I was and wonder if I will ever be the same M 73 6 months
3/12/2017
Email
 1  Prostate cancer Testicles in pain Muscle loss Depression Brain fog Lowers PSA but no quality of life left Recommend orecitomy instead M 73 12 months
Yes
5/1/2017
 1  Prostate cancer Excruciating testicle pain M 73 4 months
9/12/2016
 1  prostate ca. EXTREME FATIGUE and pain in shoulders/ back of legs just before the fatigue hits, when it comes on I can't walk 10 feet without have to take a deep breath and sit down,loss of libido ( I was a very active man for treatment (I also had 45 radiation treatment) but after the 3rd shot, I couldn't take the extreme fatigue anymore so I stopped taking this treatment- it has been 6 weeks since my monthly injection and still feeling the same. The doctor says it takes at least 3 months for the lupron to leave your system. I would NOT recommend the drug to anyone until the do a thorough research of possible side effects - there must be an alternative. For me Side effects are life changing and I am hoping that the doctor was right in telling me it will take 3 months for the LUPRON to wear off M 73 3 months
30 mg 1X M
8/29/2016
Email
 4  Prostate Cancer Hot flashes, fatigue, lack of ambition, joint/muscle pain, no libido or erection. I had a radical prostatectomy in 1991, external beam radition in 1994, started intermittent androgen deprivation (Lupron 4mo.) in 1999. After each form of treatment my PSA dropped to .00, then gradually rose to 3.0 to 4.0. Now I have a Lupron shot whenever the PSA reaches that level. After a Lupron shot the PSA always drops back to .00, however the time it takes to again reach 3.0 to 4.0 is becoming less and less. Now it reaches that point in just 6 to 8 months. Lupron has worked well for me. I'm still alive! Even with the side effects it's better than the alternative! M 72 8 years
8/8/2008
  

LUPRON  (LEUPROLIDE ACETATE):  Leuprolide is used to stop early puberty (precocious puberty) in children. It helps to delay sexual development (such as growth of the breasts/testicles) and the start of menstrual periods. It also helps slow down early bone growth to increase the likelihood of reaching normal adult height. Leuprolide works by decreasing the amount of sex hormones that a child's body makes (estrogen in girls, testosterone in boys).   FDA Approval Date: 1985-04-09 (Sources: U.S. Centers for Medicare Services, FDA)

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