AYGESTIN Reviews (NORETHINDRONE ACETATE)

Average Rating: 2.9 (163 Ratings)

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AYGESTIN  (NORETHINDRONE ACETATE):  This medication is used to treat women with abnormal bleeding from the uterus. It is also used to treat women who have stopped having menstrual periods for several months (amenorrhea) but who are not pregnant or going through menopause. In addition, this medication is used to treat a condition (endometriosis) in which tissue that normally lines the inside of the uterus is found outside the uterus in the abdomen/pelvic area, causing painful/irregular periods. Norethindrone is a type of female hormone (progestin). It is like the hormone progesterone that your body makes naturally. This medication works by stopping the normal growth of the uterus lining during the menstrual cycle and signaling hormone changes in the uterus to restore normal menstrual periods. This medication must not be used to test for pregnancy. Progestins are not effective in preventing miscarriages.   FDA Approval Date: 1982-04-21 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on AYGESTIN: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR AYGESTINCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 3  To relieve hot flashes Exhaustion, weight gain, some depression and slight rise in blood pressure. Feeling bloated and some difficulty breathing. This drug was prescribed to relieve hot flashes brought on by the Viadur implant placed in my arm after radioactive seed therapy(Brachytherapy)for prostate cancer. This drug did relieve the hot flashes but the side effects worse than the cure. I will contact my doctor to possibly change the dosage. M 80 36 days
11/6/2008
Email
 5  heavy periods no side effects it saved my life and cured my anemia F 60 5 years
2/13/2009
 5  Heavy periods I started on this drug for heavy periods and pain. The symptoms cleared up right away. A great side effect was uterine orgasms, in addition to vaginal orgasms. I don't really know if it's a side effect, but I had one for the first time the first night I took the drug. I love being able to schedule my period. I get my period 4 days after I stop taking it. My periods are lighter. I did get a sun spot on my face about 2 years after starting the drug. I don't know if it's related to the drug. I also have night sweats now. I think this has more to do with me getting closer to menopause. I wonder if this drug prevents me from reaching menopause. I am 59 and still get periods. My sisters reached menopause at 52-54 years old. F 59 100 days
5 1X day
7/19/2021
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 5  heavy bleeding, horendous cramping No side effects! This was a miracle and I avoided having a hysterectomy. Periods stopped completely - no side effects at all and only had to take 5 mg. per day. I went from periods so bad I could not function to feeling great and no periods at all. I have just stopped taking this a few days ago as I am now 55 and hoping all this is fially over - but it really made my life so much better! F 55 5 years
5 mg 1X day
6/16/2010
Email
 5  Very long, heavy periods None Very effective. Have had no bleeding in 10 years. I'm 55 now; however, I can't figure out if I menopausal or not. Drug has messed up test results. F 55 10 years
5mg 1X day
2/7/2016
 4  Severe bleeding and hormone imbalance I was in severe pain and bleeding couldn't stand up or nothing. I couldn't function at all. Just cry in pain. It lasted for three months. Then I seen a different doctor and was put on Agestin or Norithindrone. It stopped my pain and blowing with in a day. Now I have been on it for two years and within that time, I have rapidly gained weight. I was 120 and now 171, it has caused my hair to stop growing, not sleeping good, blood pressure issues and shortness of breath. I feel as though I made a deal with the devil, he took away my bleeding and pain just to sacrifice other things. I don't feel young and beautiful and slim anymore, instead I feel as though I look like Petunia Pig. My gynecologist blamed it on my binge eating after the loss of my Husband. Not so.... my family I stopped eating for weeks. F 55 2 years
10 mg. 2X day
9/8/2020
 1  Endometrial Hyperplasia After one month of taking the 5 mg. pill, I suddenly felt nauseated and dizzy daily, and I began to bleed to the point where I am changing my tampon every two hours and have to use pads as a back up. Never mind the ACCIDENTS that have to be washed daily! I also have severe cramping. This has been going on for four days straight. Due to all of these symptoms, I had to take yet another medication daily for nausea and NSAIDS for the groin cramping. Who needs this? How can you live or work experiencing this misery? Mind you, I am in menopause and no longer have ovaries! The doctor was sympathetic, but I took myself off this poisonous, medical roller coaster ride! I will have a biopsy and/or D&C or surgery and go from there. Quality of life is everything! When I was on the low dose tricyclic birth control, it changed my menstrual symptoms for the better. I had no clue about the nightmare ahead. What happens when you finally get off of or take yourself off this medication? Do you actually get better? No one knows! My doctor could not tell me how much longer would have my PERIOD and associated symptoms. Do your research and take control over your health. By the way, insist on sedation if you are going to have an in-office uterine biopsy due to Covid-19, etc. It is extremely painful even though the cervix is numbed. Your doctor will have to prescribe a controlled substance. I was shocked when I had these violent symptoms after having had no symptoms for the first month I had been taking Aygestin. There is a significant list of medications that Aygestin and its generic form, norethidrone acetate, react with. Educate and advocate for yourself! F 55 30 days
5 mg Daily
6/27/2020
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 1  Endometrial Hyperplasia After one month of taking the 5 mg. pill, I suddenly felt nauseated and dizzy daily, and I began to bleed to the point where I am changing my tampon every two hours and have to use pads as a back up. Never mind the ACCIDENTS that have to be washed daily! I also have severe cramping. This has been going on for four days straight. Due to all of these symptoms, I had to take yet another medication daily for nausea and NSAIDS for the groin cramping. Who needs this? How can you live or work experiencing this misery? Mind you, I am in menopause and no longer have ovaries! The doctor was sympathetic, but I took myself off this poisonous, medical roller coaster ride! I will have a biopsy and/or D&C or surgery and go from there. Quality of life is everything! When I was on the low dose tricyclic birth control, it changed my menstrual symptoms for the better. I had no clue about the nightmare ahead. What happens when you finally get off of or take yourself off this medication? Do you actually get better? No one knows! My doctor could not tell me how much longer would have my PERIOD and associated symptoms. Do your research and take control over your health. By the way, insist on sedation if you are going to have an in-office uterine biopsy due to Covid-19, etc. It is extremely painful even though the cervix is numbed. Your doctor will have to prescribe a controlled substance. I was shocked when I had these violent symptoms after having had no symptoms for the first month I had been taking Aygestin. There is a significant list of medications that Aygestin and its generic form, norethidrone acetate, react with. Educate and advocate for yourself! F 55 30 days
5 mg Daily
6/27/2020
Email
 3  Prolonged and heavy bleeding It helped to stopped the bleeding. Although, by simply taking 3 Advils in the morning and 3 Advils at night (I didn't know tha Advil helped a lot with bleeding from the uterus) would have helped, before taking Aygesting. Again, it did help the bleeding, but I will probably stop today or tomorrow after 6 days of taking this horrible drug. My doctor prescribed for 12 days, but I cannot do this to myself. It is toxic to me. This is NOT a natural hormone is synthetic and has many side effects. For me, it has given me insomnia, hart palpitations, shortness of breath, tingling in the face as if I had touched something caustic + bad dreams, mood swings, especially irritability! This is must not be good for my health. I cannot take 12 days of this! Better try a higher dosis of natural progesterone. F 54 6 days
5 mg 1X day
5/21/2010
 5  adenomyosis After 4 months my blood pressure went from 100/70 to 180/110 with severe tachycardia when combining this with Advil. This med spared me from bleeding to death. I posted here to warn other users about the hypertension risk when using this at high doses, especially when combining it with Advil, Tylenol or other NSAIDs. The side effects went away a few months after discontinuing both aygestin and advil. F 53 5 months
5 mg 3X day
12/4/2010
Email
 4  Prolonged Bleeding and Polyps Mood Swings, Sweating, Mild Headaches, Sleep Problems Started taking 5 mg of Aygestin to stop prolonged bleeding, after two weeks the bleeding had not stopped so my doctor increased my dosage to 10 mg. Bleeding stopped about 30 days after starting the medication. The worst thing about the medication for me has been the mood swings and waking up in the night wide awake which I have never done before. F 53 45 days
10 mg 1X day
8/30/2013
 3  To stop heavy bleeding I’m having pain in one calf. I took a step and it felt like something tore or popped inside. Not sure if it’s from the Aygestin. It feels tight, like I have to keep stretching it all. This happened after being on it a month and switching to taking it every other day Day long. Has anyone else had this type of pain? I It has stopped my heavy bleeding. I still have spotting though F 53 2 months
5mg
8/3/2019
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 1  endometrial hyperplasia acne, nausea, horrible headaches, asthma attacks, dizziness, irritability, blurry vision, numbness and tingling, swollen hands and feet, shortness of breath, pain in calves, period so bad I needed LOTS of vicodin I never should have been prescribed this!!!!! History of blood clots, phlebitis, CHF, strokes, asthma.... My life has become a living hell. I am very disabled from taking this med. I'm quitting today! F 53 2 months
8/30/2009
 5  Yes its great just ran my BP up is Only high BP dr stopped me but cant stop bleeding resumes Its a much needed med F 52 2 months
10/30/2016
 5  Heavy and prolonged bleeding No side effects so far. I had a 5 weeks long heavy bleeding with lots horrible clots. I was on Provera for 7 days and the bleeding gets worse and constant. I took Aygestin two days ago right after the biopsy, the bleeding stopped after a few hours. I am taking 5mg three times a day for a week,then will take 2 times a day afterwards. I finally can restore my energy now. I guess my body didn't react well with Provera. What's the difference between these two medication any way? Aygestin works like a magic to me, I am aware of the possibel clots, so I guess I will eat more onions and natural blood thinner and watch for the signs. F 52 2 days
2/29/2008
Email
 3  Heavy bleeding Bloating, cramping, poor appetite,spotting F 52 7 days
5 mg
7/24/2018
 2  Heavy bleeding during perimenapause cramping, leg cramps. bleeding increased over 2 days with flooding and passing clots . I was switched to this from Provera which had slowed the bleeding but not stopped it. After taking this for 2 nights I am stopping it and taking the provera again till my next appointment in 5 days. 52 2 days
5 1X day
7/20/2017
 1  ER visit for excessive blood I know that I don't do well with synthetic progesterone, but I thought I would give it a chance. The first few days I actually felt surprisingly good I thought maybe it was a miracle drug, but the sixth day I woke up, unable to cope depression, fatigue, dizziness, anger. My personality was very different. I think this drug might start out mild, and then turn on you after a week or two, according to what I’ve been reading in here. I’m looking for another solution, and I stopped taking the drug. Perhaps ablation. For me my mental health is too important to jeapordize. F 52 6 days
5mg 1X day
1/29/2023
 4  Heavy uncontrolled periods Weight gain & facial acne. This medication has made a huge difference for me. It stopped my heavy periods , but I do not know if I am even close to being menopausal, which was the whole point of taking this medication to carry me thru. My blood did not indicate anything as far as hormones levels, so we cannot tell. I had three expert opinions prior to being put on this drug. My problem is my current OBGYN is very nasty to me, and she wants to take me off of it. I am so nervous every time I see this woman that I think I am going to have to switch doctors. I am also thinking about going back to one of the original specialist to see if it is ok to stay on for a few more years, if not how do I wean off. I was just wondering if anyone who has been on this medication for a while had expirienced any side effects getting off of it. I am worried about getting that heavy cycle again, along with physical changes it could pose to me such as depression, hair and skin problems, possibly fueling estrogen. If anyone has been on this drug long term and could shed some light on how they got off of it and what effects it had on them, can you please post on this board. I would greatly appreciate any information on your expirience since the internet does not have very much information on this drug and long term use. Thank you so much. F 51 4 years
10 1X day
7/11/2016
 4  prolonged heavy bleeding Migraines in the evening usually after my second 5 mg dose. Had nausea and vomiting day 3 to 6. Dosage changed to 5 mg per day. Still feel fatigued and lost interest in going to the gym. The bleeding is gone along with the painful cramps. Don't think I would stay on this longer than 6 weeks because of the headaches. My other option is hysterectomy which I am postponing for now. This medicine did what is supposed to but with the above side effects. F 51 2 weeks
10 mg
2/25/2014
  

AYGESTIN  (NORETHINDRONE ACETATE):  This medication is used to treat women with abnormal bleeding from the uterus. It is also used to treat women who have stopped having menstrual periods for several months (amenorrhea) but who are not pregnant or going through menopause. In addition, this medication is used to treat a condition (endometriosis) in which tissue that normally lines the inside of the uterus is found outside the uterus in the abdomen/pelvic area, causing painful/irregular periods. Norethindrone is a type of female hormone (progestin). It is like the hormone progesterone that your body makes naturally. This medication works by stopping the normal growth of the uterus lining during the menstrual cycle and signaling hormone changes in the uterus to restore normal menstrual periods. This medication must not be used to test for pregnancy. Progestins are not effective in preventing miscarriages.   FDA Approval Date: 1982-04-21 (Sources: U.S. Centers for Medicare Services, FDA)

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