Drug Ratings for PAMELOR

Average Rating: 3.2 (174 Ratings)

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)   

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    Charts & graphs: Reviews Summary for PAMELOR  | Top 10 Adverse Effects (reported to FDA)

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 3  Complexed migraine Dry mouth, weight lose, lose of appetite. A little drowsy and Just feeling like I have no train of thought but still feeling depressed from time to time. I've never had to take a anti depressant so this is really scary to me. F 38 10 days
 2  severebody pain all over. No pain relief help or help with sleep insomnia. F 39 4 days
 3  Migraines Weight gain immediately and no real change to migraines. Helped somewhat with daily but continued severe migraines with menstrual cycle. Could not take generic and brand cost a fortune. Tried to go off after menopause and had severe anxiety and depression. Dr. Said probably could not stop taking after this many years. Have tried multiple times to ween off but haven't had any success. F 59 20 years
20 MG 1X D
 5  Irritable Bowel Syndrome none I have been experiencing constant stomach pain for about two years. My pain worsened after eating. I was diagnosed with IBS and prescribed several medications, but none seemed to help much. My P.A. said she wanted me to try a medication which is an anti-depressant, but had been found to help lots of other symptoms. I am very sensitive to medication and was prescribed 10mg Pamelor, one each night. After being on this medication for a few weeks, I began to feel much better. Now, I am able to eat anything without experiencing pain. F 30 days
10 mg 1X D

 3  Panic Disorder, Agoraphobia dry mouth, super drowsy during the day at first but getting better, more alert at night now, dry mouth, metallic taste in mouth, vivid but not unpleasant dreams. F 39 5 days
25mg 1X D

 2  Migraines and MAV Confusion, dry mouth, fatigue, sensitivity to light, dizziness especially when walking outside, depression, sadness, mood swings, agitation, temper. Started taking Pamelor about 6 weeks ago for Migraines and dizziness (aura). 10mg did absolutely nothing, so my Neuro upped the dosage to 25mg, once a day, in the evening. Although the painful headaches seem to have subsided, the daily dizziness is worse than before, especially when walking around outside or in areas with allot of visual stimuli. M 49 6 weeks
25 1X D
 1  Chronic migraine Confusion, unreal-feeling - like my body wasn't mine. Though I took a small dose it was still too strong for me. Felt completely unreal. All symptoms were still there but I just didn't feel them, I hardly felt anything which was frightening. Heavily sedated feeling. Back to Amitriptylin. F 45 4 days
20 1X D

 1  pain Panic attacks, vision changes, nausea, stomach pain, sweats, weakness, fatigue( falling asleep while driving ),zoned out, dissociation, crying, depression after 2 weeks, trouble waking up, horribly dry mouth, no libido. I switched from amitryptaline because of weight gain and Carb cravings-this is way worse in terms of side effects. I'm stopping it today. F 2.5 weeks
40mg 1X D

 2  Spectrum Headaches I have suffered from major depression and anxiety for a long, long time and have been doing very well for over a year now with 200mg Zoloft 200mg Lamictal and 3mg Klonopin. I had a concussion after falling in late Sept 13 and started having daily headaches. I started seeing a neurologist for help and Pamelor was prescribed because most headache meds have caffeine or stimulants which I highly allergic to. He said that this medicine had several other uses than just treating depression. He was not at all clear enough that combining this with my Zoloft was bad news. I have horrible dry mouth, confusion, and lethargy. I feel like I have the flu without the UPR and vomiting. I'm not going to take it anymore. F 34 2 weeks
25-50 MG
 5  depression & migraine Insomnia at lower doses - went away as dose increased. Makes it harder to pee & flow is not as strong. My depression makes me tired & lazy, and I shun social interaction. Tried Remeron, Elavil & Lexapro, but they all made the problem worse. Pamelor (nortriptyline) was the first drug that kicked me in the rear and made me motivated to get out of the house & get things done. M 41 3 years
75 1X D

 1  Depression Rapid weight gain (~10 lbs in about 2 weeks) Haven't experienced any benefit since it has only been 2 weeks. But I am stopping now that I have connected it to insatiable appetite for carbs & sugar. Plus, I feel even more depressed about the sudden weight gain. I was so down when it was prescribed that I forgot to ask about possible weight gain and I didn't even look this drug up on the internet until today. Well, time to find a form of exercise.... F 39 2 weeks
50 mg 1X D

 5  Chronic Major Depression Dry mouth, sugar cravings...wt gain, constipation, crazy dreams with dose changes--only lasted 1-2 days. Pamelor (Brand name med----not generic) was the medication added to Zoloft 200mg and Wellbutrin SR 450mg that took me out of my deepest depression, allowed me to sleep soundly and be refreshed in the am, and just provided me the ability to function with ease and a positive sense of well being. Unfortunately there are side effects; however I had trialed 30 + medications and various med combinations over a painful 8 year time period; Pamelor was what it took to find normalcy. (no more crying, depressive/suicidal thoughts, irritability or insomnia.) Sorry to hear everyone else's experiences; but if it wasn't for this drug (part of my "cocktail" of 3 antidepressants)....I simply wouldn't have made it this far into my life. Age 44. As of today, my pharmacy can no longer obtain the drug!! My back up plan with 90% effiectiveness is a compounded form of Nortriptyline (generic form of Pamelor). Find an integrative doctor willing to prescribe "Nortriptyline from a compound pharmacy." They only use the "Nortriptyline" ingredient and no binders within the capsule form..........it's made all the difference in the world; but nothing beats the real Pamelor. I don't know why, but generic meds are ineffective compared to the brand name for me. Trusting compound pharmacy I highly recommend--- Abrams Pharmacy in Texas. (Only $50 out of pocket--- (-$12 shipping if you're local) F 44 12 years
30mg 1X D
 5  Migraines I was originally on 100 mg but after 10 years i went to 50 mg. I was put on it for migraines when i was 4 months pregnant . I have had reduced migraines from taking pamelor. The only real side effect i had was for every 50 mg i took i gained 15-20 lbs.every time I have tried to go off of it the daily migraines have come back. It is supposed to make you tired but most meds i have an opposite effect of it so after i take it i have about 4 hours of energy. I have found to take it around 7;00 each night works best for me. I have tried several other migraine meds to help with my migraines and this is the first one that i have not grown immune to after a period of time.I have suffered from Migraines since i was four. F 46 20 years
50 mg 1X D
 2  Chronic Daily Headache and Migraine Woke up one morning and my entire body was numb. Gained 15lbs. Blurry vision. Headaches were never better. I have headaches 24/7. On top of that I get migraines if my daily headaches get out of control. She refused to take me off this med so I went to my family doc to get weened off it. Started with new doctor and new medicine. Headaches are still there just a like quieter. F 42 5 months
25mg 3X D
 5  Migraine prevention Dry mouth (chewing gum helps), decrease in migraine frequency from 21/month to 3/month, decrease in intensity: now manageable with Excedrine and feverfew. Hot flashes down by about 70%. Sleep very well now so I am more focused during the day. I exercise and eat vegetarian so weight is not a problem. I started at 10 mg/day but not effective. Increasing to 50 mg/day (I am 110 lbs) taken nightly has been amazing. Pamelor also takes the edge off, I don't feel stressed out at work and don't lose my temper anymore. I think that this new situation where I am finally in control of my migraines has made me feel better about myself and not as helpless as I used to feel. I highly recommend trying it. F 50 5 months
50 mg 1X D

 5  Migraines Before starting this medication I had migraines every day. Now, I only have them right before and right after menstruating. I haven't had any side effects, but I am on a low dose. F 27 5 years
20 mg

 3  Migraines and Post Traumatic Stress Suicidal thoughts and actions, loss of appetite, weight gain and sleeping forever. I started taking pamelor for migraines and post traumatic stress. After I take it I get headaches and I sleep for over 14 hours a night. I am never hungry but i am constantly gaining weight. Stared cutting and thought about other ways to hurt myself. Help. F 16 3 months
50 MG 1X D
 3  anxiety and depression Tingling in head some odd headaches weight gain bad blurry vision. If i wouldnt of got the vision problems i would keep the treatment F 44 3 weeks

 2   Extreme grogginess in the morning. In a daze and out of it for most of the day.I have checked my temp a few times, but no fever, just feeling flushed. I am supposed to go to 25MG starting today, but am super concerned because of the side effects. And by the way it has done nothing for my headache. F 49 7 days
10 MG 1X D
 1  Major Depression Irritability, elevated heart rate (constantly over 110 bpm,) and increased suicidal thoughts My doctor switched me to Pamelor because I was still having occasional suicidal thoughts on my old antidepressant. I became extremely irritable on Pamelor, but the worst part was that my suicidal thoughts increased tremendously once I began the Pamelor. It got to the point where, if I was awake, I was thinking about dying. I had a plan in place and intended to use it. Thankfully, my therapist got me to the hospital before I was able to carry it out. If she hadn't, I probably wouldn't be here writing this review. Also, the doctor in the hospital informed me that it's very easy to overdose on Pamelor and that it can be fatal. My prescribing doctor did not mention that at all. This drug was VERY BAD for me....almost lost my life on it! F 33 1 months
50mg 1X D
 5  Headaches I'm a little agitated but it has worked wonders for my facial pain, jaw pain and headaches caused by TMJ. I tried it few years ago bit now it works better and I'm tolerating it more. I am grateful for the relief if has provided me. M 49 1 months

 1  Depression I would absolutely NOT recommend this medication. I'm appalled as to why the FDA even allows this drug. I've experienced weight gain of 10 pounds after only 3 weeks on this drug, loss of libido and sex drive & caused me to have mood swings where I'd be punching myself in the face. I have trouble falling asleep at night then difficulty getting out of bed in the morning. M 35 3 weeks

 1  Anxiety/headaches I took it for 12yrs and it helped my anxiety and headache issue like a charm however I was very over emotional during that time and quick to fly off the handle. I didnt realize this until I went off of it last year due to increase heart palipitation that began and have since stopped since going off this. I have longterm affects from this drug, although my severe constipation i had during that time I was on it has cleared up thank goodness I have lots of urinary and stomach problems since stopping this. I feel as though this medication and its drying affect on the system created these over the long period of time i took them but didnt realize it due to nortriptyline being a pain receptor. However as soon as i went off of it everything hit me full force, constant uti's, kidney issues, pancrease issues everything in my stomach just went to hell and a year later I am still batteling this, Ive only had one doctor say that he thinks that because of the pain recepting propertys of this drug F 45 12 years
10mg 1X D
 4  Migraine headaches None Once the dosage was increased to 60 mg which I take this before bed time I have only had 3 migraines this month and it was around my menstrual cycle. I sleep great with this medication.. F 12 months
60mg 1X D
 2  Migraines I have not had any releif with this medicine. My migraines still come at least 3 times a week. And I am always thirsty and tired. I need something else........ F 36 2 months
25 1X D
 5  panic attacks never had any of those side effects. F 41 3 years

 1  Migraine I was very drowsy but as that wore off I was very agitated and I was hearing voices in my head. My ears won't stop ringing now. I don't know if I will ever be back to normal. This is a scary drug. Here are some of its side effects. Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision or other vision changes; changes in sex drive; chest pain; confusion; constipation; fainting; fast, slow, or irregular heartbeat; fever; frequent or difficult urination; hallucinations; impulsive behavior or other unusual changes in behavior; jaw, neck, or muscle spasms; mental or mood changes (eg, increased anxiety, mood swings, agitation, irritability, nervousness, restlessness); panic attacks; ringing in the ears; seizures; severe dizziness or drowsiness; sore throat; stomach pain; suicidal thinking or behavior; swelling of the testicles; tremor; trouble sleeping; trouble walking or keeping your balance; twitching of the face or tongue; uncontrolled movements of arms and legs or stiffness; unusual bleeding or bruising; worsening of depression; yellowing of the skin or eyes. How could the FDA allow this poison on the market? M 57 3 days
50 1X D
 4  Depression / Tension Headache Intense sedation .... dizziness when standing ... light headedness .... low sperm ejaculation .... extended orgasms. I was prescribed this for headache/chronic pain in my neck/head and major depression from having been sick for years. This drug for me worked great, not so much for my headaches but for the deep refreshing sleep it gave me to cope with the pain. It also lifted my depression and gave me extended orgasms. The only weird side effect was reduced sperm output during ejaculations. I would probably be dead if not for Pamelor. It really brought me out a sever depression. I guess for some people it works on headaches, but for me not so much. Desipramine on the other hand works good for my headaches but ruins my sleep cycle. M 46 10 years
275mg 1X D
 1  Anxiety/depression/insomnia This was recently added by my doc to supplement Zoloft 200mg and Klonopin 3mg. It was supposed to help me sleep. At first it was ok, but now I've noticed an increase in anger, anxiety, I'm shaky, queasy and it has never helped me sleep the night. I have horrible, graphic, vivid dreams and nightmares when I do sleep. It has sent me in to full blown panic attack mode and I am refusing to take it anymore. F 30 4 weeks
 3  Neropathy Pain\NMO PRO: Cuts pain over time and increased dosages (10mg to 75mg) CON: Rapid weight gain, loss of strength, water retention, increased appetite, poor\no erections, loss of sex drive, bloating, fatigue, very moody when starting and stopping medication Cuts the pain all though you won't feel/know it for some time, as it is a gradual process. It cuts nero-pain by tweaking the sodium channels in your cells. This causes you to hold more water and have rapid weight gain (20lbs - 30lbs). Somehow, the increased fluids around the nerves and muscles improves nerve conduction and lowers pain. The more I took, the less pain and strength I had. I went from 240lbs to 290lbs in 3 months. At 75mg, I needed a lot of help, especially getting up and down. Less strength and 50lbs heaver was hard on my wife. I had to move to 50mg to function and later to 25mg, as the side effects were still to much for me. I have wined myself off completely after 1.5yrs. When you stop it causes a wicked rebound in pain for a few weeks. It takes awhile to get through the withdraws and adjust to your old pain level. Drink lots of water during this time, as it helps. I also used Valium (PRN) and weed in the evening for pain. It did cut the pain, second best after marijuana, but the cost was too much and I still needed weed. I can live and function as a pot head, but Pamelor made me a weak, fat, blob and I can't live like that. M 47 18 months
75 1X D
 1  anxiety Well let's see where to start oh yeah has made me have fast heart rate in the 100s and low blood pressure I wouldn't recomend anyone take this drug it has made my anxiety worse do to the fact now my heart rate is always above 100 I'm hoping it goes back to normal sense I have stopped taken it and my bp comes back up . F 35 3 weeks
 4  Migraines Constantly sleepy, no appetite. Fell asleep driving No migraines since I started it. I'm not sure if I'll stay on it because of the excessive sleepiness and appetite loss. F 58 2 weeks
20mg 2X D
 2  Depression Dry mouth, trouble sleeping, vivid and I mean vivid nightmares, constipation, lime a brain zapping feeling, weight gain of 10 pounds in one month, Constantly hungry, sweating like crazy when I would sleep I would wake up drenched, and eye twitching constantly!! I would not take this just because all the side effects! F 23 2 months
25 mg 1X D

 3  Nerve pain Started off ok, now after 1 year I have extreme night terrors randoly, periods of weight gain and loss, same thing the other guy said wake up feeling light and tingly which is kind of scary, I completely lost my sex drive which I ended up losing my fiance and girlfriend of 6 years from. But it also makes me not care, which is good and bad. It does help pain but the side effects are starting to outway it. I didnt know many of the side effects where from this until I started with the extreme night terrors and put 2 and 2 together. keep track of your side effects and weigh them carefully. 3 years of no sex drive ended my relationship with fiance. M 24 3 years
up to 125m 1X D
 1  Depression Pamelor was the first antidepressant ever prescribed for me. Severe side effects of 1) soaking sweats 2) dry mouth 3) painful constipation. That was 1989, age 30. When stopped first two stopped but have had progessively malfunctioning gastrointestinal system since. Now age 52 lower GI pretty much doesn't function without pain, strain, more pain. Had no issues whatsoever with this, perfectly normal until took Pamelor, ever since lower GI/bowel has gotten worse and worse. Recommendation, if you have the bowel/constipation side effects while taking Pamelor consider there may be possible long term effects. i would not recommend it to anyone. F 52 2 years
dnt rcall 2X D

 2  depression My heart would race a lot, it caused anxiety and did not help with my depression. I took Pamelor 25 ago and it pulled me out of major depression. Since then i have had many episodes of depression and anxiety. The SSRI drugs worked for me especially Prozac. I am just starting on Viibyrd...hope i do well on it. F 54 3 weeks
50 mg 1X D
 5  Headaches Sometimes a hot face and pressure on head but the doctor said it could be caused by headaches that are going away. Increased appetite that i love Pamelor so far is working amazing for me i cant believe it. I used to get 3 or 4 headaches a day and have to drink caffeine to take them away. i was on excedrin every day about 6 pills a day for headaches and then i quit the excedrin and got headaches everyday for 2 months. then the doctor gave me pamelor and it started working within 2 weeks. my life has got so much better and i can do stuff now. im so glad this worked. i still do get little headaches sometimes but they go away pretty quick. now all i drink is a espresso with little caffeine in the morning and keeps the pressure off my head. M 30 3 weeks
50 1X D
 2  Nerve pain M 45 6 months
75mg 1X D

 3  Depression Dry mouth, trouble peeing, anger flashes, aggressive thoughts This is my 2nd attempt at pamelor, taken in desperation of finding something that can get me out of the black hole and still leave enough of me to make being out of the hole worthwhile. Pamelor doesn't effect my libido, which is great, but the anti-depression side is questionable. I have mornings when I really wonder if I'll make it through the day. The black hole isn't very far away. M 50 3 months
75mgs 1X D

 5  Migraine & Tension Headaches hyper-emotional, difficulty falling asleep and staying asleep but did not feel tired as a result, loss of apetite I had had an almost constant tension headache for nearly 3 months due to excess stress that was punctuated by severe migraine headaches. NOTHING my doctor perscribed would make them go away. Finally when I saw a neurologist he perscribed the Pamelor and four weeks later I've been completely headache free for almost a week now. For me the side effects are definitely worth the result. F 25 4 weeks
30mg 1X D
 3  migraines/insomnia dizziness/lightheadedness, groggy feeling, muscle twitches Im not really sure this drug helped my headaches or not. I did not experience weight gain or loss. F 30 5 months
20mg 1X D

 1  Rectal Spasms Severe Migraines, sweating, nausea, intestinal distress and pain, urination difficulty. ringing in my ears. night sweats so intense, bed has to be changed. dry mouth. suicidal thoughts and over 30 pounds of weight gain loss of muscle tone and growth. drop in libido and testosterone levels. Would not recommend this medication for any purpose. The side effects are numerous and severe, not worth taking. M 49 12 months
10 2X D
 1  diabetic neuropathy pain Couldn't sleep, felt disconnected, in a daze, no energy, lost weight, dry mouth, then the real problems started, vivid dreams, heart pounding, muscle cramps, couldn't catch my breath, started seeing things, sweating, dizziness, you name it. It almost killed me! I flushed the pills down the toilet... M 52 20 days
25mg 1X D
 4  headaches & migraines constipation, very dry mouth, change in hormones, decrease in appetite, weight gain (about 5-7lbs) I tried numerous RX to help my headaches/migraines. I was supposed to start at 10mg each night and increase to 100mg a day. when I reached 30mg my headaches decreased greatly, so I stayed at 30mg/day. my mouth is very very dry all of the time & Im constantly drinking water because of it, wake up in the middle of the night choking bc of dry mouth. no bowel movements for days which decreases my appetite, but also gave me heartburn (which I never had before) also bc of the constipation if I went to many days without movement I would throw up bc I was so backed up. gained a little weight but kept it maintained by working out more than usual. bc it changes your hormones it fought with my birth control and would cause acne, but did make menstration a lot better for me! the effects of this were worth it. I went from having a headache every day for two years to just once or twice a wk. I have been off of it for about a wk and still headache free so far! but I am very very tired. F 23 5 months
30mg 1X D

 2  Depression, anxiety Painful urination kicked in right away - had the urge to go, but took forever to get the stream started. As a mood-lifter, I think this worked reasonably well, but the urinary problem was a deal-breaker. Maybe the urinary hesitancy would wear off in time, but after 4 weeks, I had to call it quits. 52 4 weeks
25mg 1X D

 1  nervousness/colitis caused severe chest pain - crushing pain, then severe joint pain in hips, shoulders which lasted 2 days. worst 2 days of my life. I had just had my annual exam and EKG, how could I be having a heart attack 2 days after my check up. Unlikely!!! but it was brought on by the drug Dr prescribed Pamelor, it was filled by a generic made by Teva. I submitted a report to the FDA. F 50 2 days
25mg 1X D

1X D
 5  Nerve Pain I do not feel sleepy, in fact I seem to be more energetic. It has curbed my appetite...I have lost 5 lbs already. I crave vegetables like crazy! I have dry mouth like crazy, but if I brush and mouth wash it helps. Dry mouth is bad for your teeth and most pain meds/anti dep. cause this so up your dental care, as it promotes bacteria to grow as there is no salivia to help wash it away! As for the pain...it has helped IMMENSLY! I seem to be a bit more emotional, but not in a bad way. I also take a low dose of Celexa (10 mg) which made me gain 20 lbs. over the last two years. For some reason they work well together and I have stuck a pefect balance. I am able to reduce my pain medication as not as much is needed any more. I am optimistic that the results will continue. I was very worried about weight gain as most people talked about that, but so far I have lost 5 lbs. Also, it has not affected my bath room habits one bit. Again, I cannot stress enough that proper dental care is paramount when on any medication. The bacteria in your mouth gets below the gum line to cause periodantal disease. Learn from my mistake! I have to see a dental hygentist ever 3-4 mos to keep from falling out. Scary!PS The reason I am on all these meds is that I was in a terrible car accident many years ago that cause some pretty bad long term damage. I hope this helps. F 37 7 days
10 mg 1X D

 3  Nerve pain from spinal cord surg drymouth, ringing in ears, low sex drive (inability to ejaculate) I'm taking generic form -- nortriptylene. It's helping the pain noticeably (though not anywhere near eliminating it) in conjunction with Gabapentin. Trying to decide if it's worth all the side effects. M 51 3 months
75 1X D

 4  depression/panic disorder constipation, dry mouth, dermatitis, rapid heartbeat This med helped me cope with a major depression/panic disorder about 13 years ago. It was most effective for the first few years. Gabapentin and alprazolam helped mitigate the anxiety. I stopped taking it over a year ago- It had outlived its usefulness. I mistakenly thought it contributed to a urinary problem (most likely was a separate- age related issue) However, the drying effects of this drug can mess with your digestive and urinary system. All in all, it was much more helpful than not- especially since I was terrified of ssri's after a miserable experience with zoloft. M 60 12 years
150mg 1X D

 1  panic Such horrible constipation that I needed hospital care. Sleepiness but did stop panic M 48 2 months
20 1X D

 1  depression. terrible headache, nausea. only side effects, no wanted results. M 24 2 weeks
25 mg 3X D

 5  tension headaches Dry mouth, worse during times of anxiety. Dizziness upon standing. Strong ringing in ears. I did not experience any weight gain or loss. I used to have headaches 90% of the time, now maybe once a month. The side effects were worth it to me. Upon decreasing dosage to wean off of drug at advice of doctor, I am having EXTREMELY vivid and disturbing dreams. F 27 8 months
50mg 1X D

 4  recurrent migraine headache F 41 4 days
10mg 1X D

 3  migraine very tired,sluggish,sweating, anxiety, mental fog. supposed to increase slowly to 100mg. F 59 1 days
10mg 1X D
 2  Tension Headaches increased heart rate, increased blood pressure, fluid retention, consitipation, reduced sex drive, severe dry mouth, severe anxiety, panic attacks, disorientation It got rid of my headaches for the most part, but I had a lot of side effects, the worse being a resting pulse of 100 bpm and severe anxiety. After coming off my pulse was back to normal within a week, and anxiety was completely gone. M 30 2 months
75 mg 1X D

 4  migraine headaches lost sex drive F 54 6 months

 3  Tension headaches WEIGHT GAIN, sugar cravings This drug helped me at first, my headaches were not constant and I could function during the day. Eventually it stopped working and I switched drugs. I didn't mind Pamelor. The weight gain was crazy though. I gained like 50 pounds. Also a definite sugar craving. I would recommend this drug if you don't mind the weight gain F 19 2 years

 4  MS Related Symptoms/ Depression None really, besides dry mouth and skin sensitivity to sun. Pamelor took over 8 months to start working, but it was the first drug that my body received well, without any serious side effects. My neurologist told me to hold tight and be patient for it to start working. I started on 10 mg and worked up to 100 mg. Now my psychiatrist added 25mg to ease some of my depression. I was on 200 mg of gabapentin for over a year (it worked great), and then it started making me violently throw up every day. I also used to take topamax until I started having tons of weird nightmares. Overall, I am happy to have relief with Pamelor. Now most days my body is free of tingles, and the nerve pain is reduced greatly. I have added a lot of vitamin supplements as well, and my new psychiatrist is having me take EKG's and blood work to make sure the drug is not causing any harm to the rest of me. The dry mouth just causes me to drink more water, so I am happy about that. F 29 1.5 years

 1  Depression The side effects were terrible. It turned my skin an awful dark color. The worst side effect was enormous hostility. Pamelor did relieve the depression but at an enormous cost: I want from being angry and irritable to being extraordinarily hostile. The hostility persists long after I have stopped taking the drug. Something in my brain was knocked out of balance and never returned to normal. I truly understand--without condoning--why people on antidepressants shoot up schools or something. These drugs can have some really bizarre effects. It also gave me brutal PMS and insomnia for the week before and the week during menstruation. These effects lasted for YEARS after I stopped taking the medication. F 50 6 months

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