SINEMET Reviews (LEVODOPA; CARBIDOPA)Average Rating: 2.5 (87 Ratings)Filter ResultsCompare SINEMET with similar:
Type: Rx Drug
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Results are sorted by length of time drug was taken longest to shortest. Key to Ratings: 1=LOW (I would not recommend taking this medicine.) |
More on SINEMET: Reviews Summary | Drug Safety Information
| RATING | REASON | SIDE EFFECTS FOR SINEMET | COMMENTS | SEX | AGE | DURATION/ DOSAGE | DATE ADDED |
| 4 | diagnosed with PD 39 years ago | I have all the side effects that you have with Sinemet also I take Comtan along with the Sinemet. . the last few years I have a lot of sweating as the drug wears off & before I can take the next dose. As the next dose takes affect my sweating just stops instandly until it starts wearing off again .That is the worst side effect that I have after all these years. | F | 69 | 39 years 100/250 7X day | 2/16/2016 | 4 | for Parkinson's | I get spells where my jaw gets stiff, my hands get stiff, my toes curl up, I have difficulty walking, my blood pressure goes up, i sweat and have to lay down. Doctors can't figure it out. I was doing okay until I got the flu last January and have been miserable ever since. One doctor went so far as to tell me I don't have the disease because my brain MRI does not indicate such. | F | 76 | 14 years 25 - 100 9X day | 12/5/2014 | 3 | I have MSA with Parkinsons symptoms | Hallucinations and after 10 years my front teeth are cracking. | Sinemet helped with movement. I take 1/2 a pill twice a day. | M | 73 | 10 years | 9/7/2009 | 2 | my mon | Hallucination | Like somebody has aknife and wants to kill her | F | 69 | 10 years 110 | 1/31/2016 | 1 | PD | This drug combined with depression causes many problems with my mom. I feel the Dr. over prescribed this drug and my mom became addicted. She was obsessed with getting her pills on time. The hallucinations this drug causes for my mom are horrible. She is like a schizophrenic now thinking that everyone is out to get her. At 62 my dad did not want to take care of her so she ended up in a psych ward at 62 and than a dementia nursing home ward. | STAY OFF THIS DRUG AS LONG AS POSSIBLE. | F | 67 | 10 years 10X day | 7/8/2012 | 3 | Parkensons | Severe start of dose and end of dose dyskinesias | Makes me very tired during the day | M | 59 | 8 years 900mg p/d | 4/4/2015 | 5 | restless leg syndrome | possibly night sweats, they started about the time I started the medication. The sweats could be from thyroid. | Before I started taking Sinemet, I could not sleep for all the jerking motions of my legs. That problem doesn't exist with the medication. I take one every night 30 minutes before going to bed. | F | 47 | 7 years | 4/30/2005 | 5 | Parkinson's | None cause I started very slowly with much less than prescribed to allow my system to get used to it. | Very good / very bad. Classical situation where a drug seems to address exactly what is going wrong in the Parkinsonian's brain and that is the diminishing capacity to make our own levodopa (which is what sinemet is). Levodopa in a healthy person is made in our bodies from basic nutrients. Levodopa, in turn, is converted to Dopamine, which in balance with two other neurotransmitters, acethylcholine and GABA, provide for smooth and controlled movement. Throwing ready-made levodopa into our bodies causes a well known pharmacological effect called | F | 48 | 7 years | 6/10/2005 | 4 | Young onset Parkinson's disease | It is the Gold standard of PD drugs for me, it helps tremor or the lack of movement, it is a good drug but it has an = on /off phenomena after 3-6 years, to much can be as bad as not enough. | Sinemet is a good medication for me, yet it is not a cure. | F | 37 | 7 years | 9/28/2004 | 4 | ideopathc young onset parkinsons | start of dose dyskinesia and severe dyskinesia at end of dose (evenings)Very tired during day,lack of energy and self motivation.. have now developed a new symptom -over-breathing whilst having evening dyskenesia which leaves me breathless till I fall asleep.I presume it is from all the exertion and ballistic movements. | i still have relatively good results from my sinemet (high dose)I have a lot of freezing episodes now lately even if i am "on"I know there is no way I can reduce my dose because if I start fluctuating, I will experience these horrible dyskinesia's. I know most pd patients that suffer from dyskinesia gets the peak dose variant-I get the diphasic type which come in effect when my brain reaches certain (low) levels of levadopa (dopamine).There is no effective treatment yet and it leaves most specialists puzzled,The doctors always say to come down with the dose, but it is wrong to compare this type of dyskinesia with "peak dose" dyskinesia as it seems to work just the other way around. amantadine also has no effect on this type of dyskinesia.Lowering the dose of sinemet is also disastrous because then I experience more fluctuations and dyskinesias.My Doctor once made the following remark." we'll have to come way down with your dose,you don't need to be Tarzan the whole day"My word! As I still contribute to the household as a whole and my sinemet still carries me through the day albeit a high dose,I cannot go into total freeze- up, or suffer with the low dose fluctuations/dyskinesias I am afraid adding agonist medications will just prolong the dyskinesia when I take my last dose of sinemet in the evening. I know there is some research going on long time in finding a treatment for this side effect,and that some anti epileptic medications shows pr | M | 59 | 7 years 25/100 8X AN | 5/15/2015 | 3 | Parkinsons | My husband had major side effects: hallucinations, paranoia, increased anxiety, screaming fits, throwing himself out of bed..it was terrible. But after awhile, seemed to adjust. He began with it 3 times a day, but is now up to 7. I think I read that the max that should be given is 8 which he is quickly approaching. | He takes an anti psychotic drug (Seroquel) and antidepressant (Prozac) in addition to the Sinemet which seemed to eliminate hallucinations etc..Sinemet seemed to decrease drooling and mask like facial appearance. His hand writing is still extremely small, his voice very soft. He is in a wheelchair and unable to walk. My understanding is that he is in the Advanced stage of Parkinson's. Recently, he has increasing dystonia on the left side (leaning), and left foot twisting. | M | 84 | 7 years 25/100 7X day | 7/10/2015 | 3 | Parkinson's disease | Sleepiness, dyskinesia, mental slowness | For those recently diagnosed with PD: take advantage of all you can - you'll never feel better than you do now. I was diagnosed with PD in 2001. I've taken Sinemet for 7 years. After 6 years of relatively good control of my PD symptoms on Sinemet, I began to have dyskinesias or unintentional or dystonic movements and spasms. My co-workers thought I was drunk. But inside I was a mass of clenched muscles, especially in the jaw, neck, upper body. Sinemet kept me going rather smoothly for 6 years, but now I walk a tightrope between PD symptoms and side-effects. Sinemet also slows me down mentally, like I was drugged. (Laugh - I am!) These days I take a nap almost every day, out of necessity, in order to get through a work day, which for me is the evening shift. I'm a musician. | M | 55 | 7 years | 7/17/2008 | 5 | Young Onset Parkinson's | Occasional dyskenesia if I dont dose correctly, ON/OFF periods | Saved my life! I medically retired at 33 from the Air Force. SINEMET is the medicine that helped, all the agonists had extreme side effects. SINEMET has allowed me to go back to work as an IT specialist. | M | 38 | 5 years | 1/11/2005 | 2 | Parkinson's | Extreme on off dyskinesia, dystonia, Cognitive problems of all kinds. Cramps, joint pain, muscle and soft tissue damage from dyskinesia. | If someone had only told me that I would be totally overdosed and become addicted to this drug! What I thought was Parkinsons's disease is nothing more than the ravages of sinemet addiction. How do I decrease dosage and get back to normal Parkinson's disease and symptoms? | M | 55 | 5 years | 12/25/2004 | 1 | Osteoperosis | My father has been taking Sinemet for 5 years. He has experienced dreadful hallucinations, paranoia and psychosis. Shocking visions of ugly monsters and people trying to murder him and his loved ones. If he had alcohol at his disposal he would have become an alcoholic too, there we're signs of additiction type of behaviours. | My father began taking this drug at the age of 80 and we believe he was overmedicated by the nursing home he was living in. This high dose has now caused terrible mental problems for my father that he would have been better off without it and at least sane. | M | 86 | 5 years 250mg 4X day | 5/21/2011 | 1 | Parkinson's disease | Terrible confusion, weakness, hallucinations, difficulty in walking. Every.time I suggest that this drug is causing problems, the neurologists deny it. It is their answer to everything. I also discovered how much neurologists get from their conferences connected with drug companies. It was so discouraging to see the money they make on a drug that is causing more problems for the people who are already suffering. | F | 63 | 5 years 4X day | 2/14/2015 | 1 | parkinsons | totally addictive - brings on parkinsons symptoms, this is the worst drug I have ever taken | M | 61 | 5 years 10-20 4X day | 11/11/2015 | 1 | Parkinson's Disease | My Mom has severe depression and anxiety. She was originally diagnosed with PD and given Sinemet to help with slight tremor and balance issues. Has become addicted to Sinemet and can't come off of it. takes 4 pills a day. | Don't believe that perscribed Sinemet has ever worked for her slight tremors. I believe it has only made things worse for her. | F | 77 | 5 years 25/100 | 3/2/2022 | 4 | Parkinsons | Nausea, insomonia, | M | 49 | 4 years 25/250 mg | 3/22/2017 | 4 | Parkinsons | None noted. | F | 66 | 4 years | 4/17/2006 |