DEPO-PROVERA Reviews (MEDROXYPROGESTERONE ACETATE)

Average Rating: 2.1 (2470 Ratings)

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 ESTROGENS PROGESTINS ANTINEOPLASTICS

 Type: Rx Drug

  

DEPO-PROVERA  (MEDROXYPROGESTERONE ACETATE):  This medication is used to treat certain types of cancer (such as uterine cancer, kidney cancer). Medroxyprogesterone is like a natural hormone called progesterone made by the body. It is usually used with or after other treatments (such as radiation, surgery). Medroxyprogesterone may prevent or slow the worsening of the cancer and decrease pain and other symptoms.    (Sources: U.S. Centers for Medicare Services, FDA)

  

Results are sorted by length of time drug was taken longest to shortest.

Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on DEPO-PROVERA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR DEPO-PROVERACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  to regulate my periods i was 34 years old with a very irregular period.my doc and i thought it was due to a thyroid disease. ( graves disease)so the depo was to striaghten out my hormones and allow me to be period free.i thought it was working untill i received my lab results.i was not having my period because I had gone thru the "change"so than i started taking prempo,which i still take.thru the years i always had to watch my weight.i was able to put on and take off the pounds fairly easily.in the past two years i just kept adding and unable to take off. my doc sent me to a metabulism expert.my labs came back showing i lacked all tetestrone in my body.he said this was due to the use of prempro,which decreased my eslvadiol.has anyone else gone thru this?i will start taking the tetestrone next week. F 60 30 years
10/25/2007
 5  original reason - birth control I haven't had a period in 20 years. I did not plan on having children, and this was a blessing for me not to have to worry about pills. I started taking Depo approx 20 years ago - this is telling my age....I just returned from the Dr and he refuses to give me any further injections. His reasoning "you are too old and since there is no chance you can get pregnant, I will not give you further injections." I am completely frustrated. He further said that I have probably (PROBABLY) went through menopause so there is one more additional reason to not take the injection. I am 53, and I do not want to chance having periods, nor do I feel like he has the right to make that determination for my body. 20 years
10/2/2008
 4  Birth Control Honestly, none. See additional comments. Yes, I have been on Depo for 20 years. I never wanted children and had horribly painful periods when I was younger so this was a miracle drug for me. I did not spot or bleed like most seem to do, I did not bleed for 20 years. LOVE THIS DRUG. But - you are not supposed to be on Depo more than 5 years, and I paid for that. My current GYN forced me to have a bone density scan last year, I now have Osteopenia (On-set of Osteoporosis) :( He said this is my last injection to pick something else. I do have daily aches and pains, especially when climbing the stairs in my house, bones pop and creak and I am only 40 years old. I am a smoker so BC pills were not an option for me. In the new few months I will be getting the Implanon implant in my arm. Praying it works similar to Depo. I know people have horror stories about Depo, but I am one of the few who loved it, yet paid the price for it by staying on it too long. F 40 20 years
150 1X O
2/25/2015
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 5  Birth Control Occasional spotting if I am overdue for needle. I have no period at all and it has been extremely effective as birth control F 42 19 years
3/20/2007
 5  Birth control Weight gain...maybe have poor diet. No heavy cramping cycles. Yeah. F 53 18 years
100 1X O
9/23/2010
 5  Prevent pregnancy While I was on the depo shot, I had no side effects. I did not have a period (which was a plus) and it successfully prevented pregnancy. However, I have since stopped, June 2020 (due to age, I'm a smoker, etc.) and the only side effects of stopping I have experienced this far is breast tenderness and fatigue. F 40 18 years
4X O
10/25/2020
Email
 1  Stop pregnancy, period Extreme fatigue, constipation- no bowel movement for up to 5 days, mild depression, pain in joints (knees, fingers, wrist), loss of sex drive, vaginal dryness, bladder and abdominal pressure, constant thirst for pop and water, frequent urination, bloating- around waistline looked 6 months pregnant, bloated looking face, finger swelling, excessive body hair growth, body weakness, poor circulation- arms and shoulders numb upon waking, obsessive thoughts, extreme paranoia, increased acne on face chest and back, poor digestion, constant burping and heartburn, severe hot and cold flashes, mood swings (very angry never happy), blurry vision, overall body aches low back pain, hair dry and brittle, fingernails brittle, boil like cysts on buttocks and vagina, nervousness and anxiety. catch colds and sick constantly, shortness of breath, increased mucus in the throat. very hypoglycemic- get shaky, sweat and bottom out . Loss of interest in life and very antisocial and constant feeling if being i I would not recommend to anyone!!! I personally loved the shot for 10 plus years no side effects to think of except a little weight gain but was fine with that because I was very skinny. But the weight kept coming and I have gained 90 pounds so far. My major side effects started 10 years ago, but never made the connection to depo being the cause. I stopped 3 years ago to let my body rest and after I got my next shot 6 months later everything hit me with a vengeance. I just recently turned 40 and I thought I was going into early menopause. I am off the shot 7 weeks and suffered a severe withdrawal last week I was stuck laying in bed for 6 days with extreme fatigue, severe depression, very scary I wanted to end it all, body aches, night sweats, slept for 14 hours at a time, body acne, smelly discharge, no appetite and extreme anxiety. I feel a little better but still scared it might all return I do not have the strength to fight it. I am taking macafem and it has helped with the symptoms but I do not feel 100% yet and still feel very weak. This shot is a poison and evil because it has a way of masking itself and leads you to believe its not the cause. Please stop using this and find another b/c or do not ever consider if you are looking for a b/c. It will all catch up to you eventually, not having a period is toxic to your body and can destroy your well being. Please say a prayer for me I really need some!!! Thanks for reading and God Bless. F 40 18 years
250 mg IM 1X AN
7/9/2011
Email
 1  to control menstrual cycle leg cramps,headaches,abdominal pain,degenerative disc & joint disease,fatigue,weight gain,lower back pain constantly,neck pain,emotional side effects, joint pain throughout body...etc. After finding out the side effects from this website and information given to me from my neice, I will not suggest anyone to be given this shot. It has done extreme damage to certain parts of my body. I have no insurance and cannot afford the tests needed to determine the damage this shot has caused. The doctor never bothered to tell me the side effects other than weight gain and possible breakthrough bleeding. He also neglected to tell me that you are only suppose to take this shot no longer than 5 years. I have been on it for 18 years, and have not had a period in 17 1/2 years. I was asking my recent doctor about this shot, she took me off of it IMMEDIATELY after realizing that I have been on it for so long. If any of you have any other information about this shot, please email me. God Bless You! F 38 18 years
6/22/2009
 5  Birth Control now I'm told I have very low bone density the best birth control I have ever been on. other than the low bone density. had I known, change out every five years. F 46 17 years
1X day
4/12/2012
 1  Birth control pills made me ill LADIES PLEASE PLEASE DO NOT TAKE THIS POISON!!! I had my first injection in 1997. I of all people was a depo advocate. I loved that I no longer had severe periods with pain and cramps. I had no idea that I was injecting my body with poison every 3 months. I have been diagnosed with fibromyalgia due to severe joint and muscle pain. I now have gastroparesis which means my digestive system no longer functions. I have headaches, heart palpatations, shortness of breath, hair loss and gained over 60 pounds the last 15 years. My last injection was May 2013. For the past year I have had severe nausea, vomiting and constipation. Due to this, I have lost 40 of those pounds but in the most unhealthy way. My appetitie has just begun to return but slowly. I never associated any of these issues with depo until this year. Most of the damage is irreversible and no one ever told me that this drug had a black box warning from the FDA. I pray that others will take this to heart and not put F 37 16 years
30 mg 1X O
2/19/2014
Email
 5  period control / birth control none i took depo for 15 years - from the age of 15 to 30 years old. for me it was the wonder drug - i had no side effects and no period for 15 years. i maintained a weight of 100 pounds the entire time and was so happy. a year ago, my obgyn sent me for a bone density scan, and it showed that i have the bones of a 90 year-old woman - very frail and brittle. she demanded that i get off the shot immediately in order to reverse the loss. i was on the nuvaring during the last year, which has sent my weight to a whopping 150 pounds, which at 5'4" is ludicrous, considering i have gained half my previous weight and now weigh 1.5 times what i used to. i no longer recognize myself, both physically and internally - just don't feel right, don't feel like myself. i had a mirena iud inserted last week in order to get my body back to the condition it was in during the depo, so i am currently hopeful. had my doctor not refused to continue giving me this shot, i would still be on it. F 31 15 years
12/7/2009
 5  birth control & control bleeding I guess I am very fortunate. I love the depo shot!! I have been on depo for 15 years, I have never had a single problem with it!! I did get off it briefly after having a tubal, but my irregular periods were just like they were when I was young so now once again I am back on it. I will take it forever if the Dr lets me!! F 35 15 years
8/26/2008
 5  birth control weight gain (175lbs.), hairy breasts, hairy buttox, swollen feet, nail fungus, etc. i would always come to this page and be like "i'll never be another sad depo story" but look at me today. i weigh over 300lbs, my face, breasts, buttox have had an increase in hair growth. i have hair loss on my head, so i look 80 not 35. over the months my feet have become swollen and i grew nail fungi in my toes and fingers. my husband left me, and my family has disowned me. i'm just here to let all of you know, please research the birth control good before taking any. you don't want to be another ME. don't tell me i didn't warn you! F 35 15 years
10/26/2005
 4  didn't want a baby or a period no period, no craps, no mood swings On depo for 15 years… after about 2 years no more periods, no craps, no mood swings…loved it. I have gained some weight over the years but that is due to my diet and can’t blame that on the drug. I’m 5’6 started when I was 18 and weighed 120 now I’m 145. My doctor was concerned about my bone density. Had it tested last month and it was normal but due to the fact I just had a birthday and have considered the fact I might want to have a baby someday I did not get my last shot which was due March 16,2010 about a week after my shot was due started getting hot flashes and felt totally blaaaaa. The hot flashes are gone I just got some very light spotting no craps yet but have a serious lose of energy. I normally go 2 the gym 4-5 times a week and find it hard 2 drag myself there 2 plus times. I still walk my dog 3 times a day but really wanted some helpful information on how to help my body detox faster. The sooner I can get this drug totally or as much as possible out of my system and get back to my energetic self. There is a down side to everything and at 18 I could not see that thought it was the wonder drug. Now I’m not 2 sure. F 33 15 years
1X O
4/9/2010
 4  birth control slight weight gain, headaches, moodiness when time for inj. This was wonderful even with the side effects until I reached my thirties. My natural hormones changed and I became dependant on the injections to keep my energy and moods together. When it was time for my shot EVERYONE knew it. I would recommend for temporary birth control but no more than five years. F 37 15 years
4/10/2008
Email
 2  18yrs old. I did not want children NO PERIODS(WHICH WAS REALLY NICE). NEGATIVES: STEADY WEIGHT GAIN, DEPRESSION, ANXIETY, IRRATIONAL BEHAVIOR, VERY SHORT TEMPERED, OVERLY AGGRESSIVE, BLOATING, WATER RETENTION, GASTRO-INTESTINAL ISSUES. DURING THE 15 YRS ON DEPO I BLAMED MY SIDE EFFECTS ON EVERYTHING BUT THE DEPO,I NOW KNOW THAT I WAS IN DENIAL. I SOUGHT HELP FOR DEPRESSION & ANXIETY WITH MEDICATION & IT DIDN'T HELP. NOW THAT I'VE STOPPED, I REALIZE HOW MUCH THE DRUG AFFECTED ME. 15 YRS ON DEPO. I'VE BEEN OFF OF IT SINCE 8/08. I'M NOW HAVING PERIODS EVERY 14-16 DAYS FOR 6 DAYS. I NO LONGER HAVE THE ANXIETY AND DEPRESSION PROBLEMS I HAD, I FEEL MUCH MORE NORMAL AND RATIONAL I DON'T 'FLY OFF THE HANDLE' FOR SILLY REASONS. I HAVE YET TO LOSE THE WEIGHT THAT I GAINED WHILE ON DEPO. ONE OF MY FIRST UNDENYABLE CLUES THAT DEPO WAS THE ISSUE, WAS WHEN I STARTED GOING TO THE GYM AND WORKING OUT 2HRS A DAY 5 DAYS A WEEK FOR 6 MONTHS WITH NO WEIGHT LOSS WHAT-SO-EVER! I LOST VERY MINIMAL INCHES NOTHING SIGNIFIGANT ENOUGH TO BEGIN TO JUSTIFY THE AMOUNT OF CALORIES I WAS BURNING!! I'M IN THE 'DETOX' STAGE OF THE PROCESS NOW, INITIALLY (1ST COUPLE OF MONTHS AFTER STOPPING)I HAD SEVERE CRAMPS & BREAST TENDERNESS, I BEGAN TO START FEELING MORE 'NORMAL' WITH LESS ANXIETY & DEPRESSION. I FEEL MORE 'NORMAL' AS EACH DAY GOES BY, MY PERIODS SEEM TO BE LIGHTENING A LITTLE THE BREAST TENDERNESS IS MINIMAL BEFORE MY CYCLE AND THE CRAMPS ARE BARELY NOTICEABLE. I'M SOON GOING TO GIVE THE EXERCISE ROUTINE ANOTHER TRY. I WILL LIKELY SEEK OUT THE HELP OF AN ENDOCRINOLOGIST TO FIND OUT WHAT MY BODY IS DOING.I HOPE TO HEAR FROM ANYONE WHO HAS GONE THRU THE 'DETOX' OF DEPO AFTER BEING ON IT FOR YEARS SO THAT I HAVE AN IDEA OF ANYTHING ELSE I MIGHT HAVE TO LOOK FORWARD TO. F 35 15 years
4X O
3/31/2010
Email
 1  Migraines, Birth Control Extreme decrease in sex drive, bloating, feeing hungry all the time, HAIR LOSS I was on the depo for around about 15 yrs. First thought it was brill but I didn't think my bald patch or mild depression and bloating had anything to do with it. Ihad a couple of breaks but my last shout was 3 months a go. I will never have another shot ever in my life. When I comb my hair it comes out and has stopped growing. no sex drive and acne whitch I never had before. I always rooted for the Depo shots BUT It's really not worth it. Trust me F 34 15 years
12/28/2006
 1  the doc told me to ,pain in my neck,back,hips,legs,feet,nerve damage in hips. dry skin cause me to have sore on back and head on my upper lip and chest. It is bad cant use any thing will break me out. people dont need depo povera it is hhurting alot of people l.ike me F 33 15 years
3/23/2009
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 5   some weight gain at first, reduced ovarian cyst production... ive never wanted children so i am thankful for this prevention med...easy to remember, effective, no periods for many years now, which i love! plus it greatly reduced the number of ovarian cysts i had been having. wouldnt try anything else. havent had any trouble with long term osteoporosis effects either. will continue until i dont need BC any longer. F 35 14 years
1X O
10/1/2012
Email
 4  Not wanting a period/birth control None of the normal side effects, increase sweating I guess I'm one of the lucky ones. I actually love the shot and have not had any of the "normal" adverse side effects. The very first doctor that put me on the shot in 1996 told me to take at least 1000 mg of calcium a day. I did and with calcium supplements and excerise my bone density test have come back normal. I have put on a few pounds but considering I started the shot at 22 and am now 36, I attribute the small weight gain to age, not eating healthy and not excersing as much. I do sweat more and noticed the increase sweating within a year of starting the shot so I don't know if the two are related, but it makes since that they are. However, I haven't noticed anyone else mention an increase in sweating. I've had many discussions with my OBGYN regarding the shot and he has said as long as my bone density test come back fine, I can stay on the shot. F 36 14 years
1X O
6/4/2010
  

DEPO-PROVERA  (MEDROXYPROGESTERONE ACETATE):  This medication is used to treat certain types of cancer (such as uterine cancer, kidney cancer). Medroxyprogesterone is like a natural hormone called progesterone made by the body. It is usually used with or after other treatments (such as radiation, surgery). Medroxyprogesterone may prevent or slow the worsening of the cancer and decrease pain and other symptoms.    (Sources: U.S. Centers for Medicare Services, FDA)

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