PROLIA Reviews (DENOSUMAB)Average Rating: 1.4 (285 Ratings)Filter ResultsCompare PROLIA with similar:
Type: Biological Drug
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Results are sorted by length of time drug was taken from shortest to longest duration (reviews with no time reported listed first). Key to Ratings: 1=LOW (I would not recommend taking this medicine.) |
| RATING | REASON | SIDE EFFECTS FOR PROLIA | COMMENTS | SEX | AGE | DURATION/ DOSAGE | DATE ADDED |
| 5 | post-menopausal osteoporosis | No side effects with the first shot! | F | 66 | 1X O | 3/5/2017 | 3 | Senile Osteoporosis | These injections HURT!! Then it burns for a few days at injection site. | They can't be given in the muscle, but in the arm area where most people have some fat. I don't really have any fat, and it's really painful to get. Then the injection site burns for a few days afterwards. Other than THAT, knock on wood, I have not had any other side effects that I'm aware of. I've had 3 shots so far, get my 4th in July and a follow up bone scan next January to see if it's working for me. | F | 46 | 60mg 2X O | 4/1/2016 | 1 | osteoporis | I take prolia shots 2 x yearly. Prior to starting prolia my carotid arteries in 2008 were clogged at 35% left carotid and 30% for the right. Now an arteriogram shows both severely clogged with my left carotid at 80%, surgery is scheduled 19 Feb 2016. Taking the prolia is the only lifestyle change that occurred. Could Prolia have contributed to the carotid artery stenosis. | I have taken 7 prolia shots and in March 2016 will take the next one if I decide to continue. I would be interested to know if anyone else has the clogged arteries after taking prolia for a while. | 73 | 2X O | 2/12/2016 | 1 | Osteoporosis | Drug was injected into my upper left arm. Within 2 days I experienced severe chest and back pain on the left side. I thought I was having a heart attack. One of my doctors prescribed a pain medication and it subsided over about 2 weeks later. It was a horrible experience. | F | 75 | 60 MG 1X O | 4/27/2015 | 1 | Osteoporosis | Red swollen itchy face legs and arms. Neck pain. Weight loss, diarrhea . Fatigue depression. It aged me 10 years. | It's a killer . I have every side effect possible from this drug. I called the manufacturer and they said how did I know it was the Prolia that caused all my side effects!! I will get an attorney!!! My doctor reported this the the FDA also. | F | 73 | 60 2X O | 10/31/2015 | 1 | Osteoporosis | 1st injection in July 2014. Several weeks later I developed severe joint pain. I thought I was having some weird arthritis flare up. I saw my family Dr. He put me on Prednisone. It worked until it wore off. Dr prescribed physical therapy. Sorry but you can't make this crap up. Put back on steriods. I unfortunately never connected the Prolia to my condition. It was 3 weeks later. My Dr didn't catch it either. I had my second Prolia injection on January 20, 2015. On February 2, 2015 I noticed a dime sized red rash on my knees and elbows. Some had big pustules. Oddly enough there was no itching and no pain. I still didn't connect to the Prolia. The pain and extreme joint stiffness would not allow me to get out of bed or walk without assistance. I've had two 10 day courses of Prednesone. I finished the last of it on February 27, 2015. I am again having symptoms. The rash has started and the stiffness is roaring back Oh, my Dr said to take motrin and Benadryl. yeah right | Be careful to know all the side effects of this drug. In many people the symptoms begin weeks after the injection. My Regular Dr finally figured it out The Endocrinologist that prescribed Prolia never returned my call. | F | 70 | 2X O | 3/5/2015 | 1 | Osteoporosis | Flu like symptoms....nausea, GI problems...exhaustion. Took shot on March 15th and was violently sick the following Saturday....vomiting and wretching.....haven't been well since. Went to my primary and he suggested I see a GI doctor. I asked him if he thought it was prolia but he didn't know about the drug. After reading all these reviews, I am convinced it was the shot. I was perfectly fine before March 15th. | Would not recommend. Will not take a second shot. I am concerned about the length of time it will take my body to rid itself of this drug. I missed a week of work already. | F | 71 | 1X O | 3/25/2017 | 1 | severe osteoporsis | None yet | My Bone specialist says that when you stop taking prolia you go through withdrawal and the studies shows that you then start to loose bone loss and a concerning percentage. | F | 73 | 1X day | 10/4/2017 | 1 | Osteoporosis | Passing out but can still hear everything going on around me. Very weak legs and whole body feeling weak, sore stomach, burping, nausea, whole body shaking, admitted to hospital twice for symptoms but all my vitals are okay. Will never take this drug again. | F | 65 | 1X O | 12/28/2016 | 1 | Severe Osteoporosis | With first shot had digestive issues and sores in mouth...2nd shot had inflamed tendons in both heels (I am an avid hiker and that was NOT a good thing!) and extreme muscle soreness after exercise. Also had a HORRIBLE case of Bronchitis that was very hard to get rid of. 3rd shot...insomnia, severe constipation and tightness and burning pain in back of neck and low back. I have Fibromyalgia and now THAT is flaring up! Back on Lyrica for pain and Benefiber for constipation...also depressed. Blood pressure is way up so will need medicine for THAT! Will NOT be getting a 4th shot. I will take my chances! | Try it once ....see what happens. If you get reactions, like most of us don't get another shot no matter how convincing the Doctor is. We do need a QUALITY of life! | F | 67 | 60mg. 3X O | 4/20/2018 | 1 | DOCTOR ORDERED IT | 1ST PROLIA SHOT...FINE BUT THEN THE 2ND AND I HAD SEVERE DIGESTION ISSUES MY LIFE HAS BEEN HORRIBLE NOW SINCE NOVEMBER 2017 3 DAYS AFTER MY 2ND SHOT ALL THE MUCUS IN M Y STOOLS AND BLOATING ABDOMEN AND SEVERE PAIN IN GUY AND ABDOMEN ....MY LIFE AHS BEEN HORRIBLE EVER SINCE THE PAIN IN MY THIGHS AND LOWER BACK IS SO BAD I HAVE A STOMACH AND COLON FULL OF MUCUS LOSING WEIGHT WITHOUT DIETING.. THIS IS NUTS... RUINED MY LIFE | DONT TAKE THIS RX ITS VERY VERY DANGEROUS | F | 54 | 1X O | 5/28/2018 | 1 | Dr. recommended | Severe osteoporosis 2 broken hips broken femur | A horrible drug!!! I had two shots 6 mos apart | F | 89 | 1X day | 1/9/2020 | 1 | osteoporosis | Muscle, joint, and bone pain that did not exsist before taking the one dose of Prolia. | Only had one injection and will not take any more. I did not have these side effects before I started Prolia. My vitamin C and D level is within normal range. I discontinued taking a PPI for GERD since I believe it was reducing the acid activity too low to absorb the calcium and cause my osteoporosis. | F | 78 | 60 1X O | 2/2/2020 | 1 | Osteoporosis | I'm no longer taking this medication. Symptoms took 6 months to go away. | F | 74 | 60 mg 1X O | 3/12/2024 Patient History | 1 | Osteoporosis | Constipation and diarrhea, loss of taste and appetite, Gerd and IBS increased, muscle weakness, and itching. | I agree that this drug is not good especially if you have other ailments. It also creates new ailments. | F | 65 | Injection 1X O | 8/30/2023 Patient History | 1 | Breast cancer and osteoporosis | I'm no longer taking this medication. | F | 60 | Shot 1X O | 3/24/2024 Patient History | 5 | Osteoporosis | Dosage: 2 sub-Q shots per year. I had one shot 2 months ago and haven't had any side effects at all, thank God! I hope it continues to be side-effect free in the future. I am almost 51 and I have osteoporosis. | I broke my ankle a few years ago just by rolling it off a sidewalk. It was very painful with a long recovery. This medication is supposed to increase bone density. There are also risks for one's blood calcium to decline while taking this medication. | F | 50 | 1 times 2X O | 1/31/2013 | 3 | Osteoporosis and severe Osteopenia | I felt very tired after taking the injection the next day and have had stomach pain and neck pain. I am young to have Osteoporosis and am having a difficult time finding anyone my age to find out the effects of taking Prolia for longer periods of time while still having a mensus. I also have Short Bowel Syndrome and Crohns Disease. | F | 40 | 1 times 60mg 1X O | 7/18/2014 | 2 | Osteoporosis | Within 1 week of my 1st injection I started picking up various viruses after being virus free for the previous year,that along with serious fatigue and flu like symptoms, and over the followig months-increased lower leg bone pain with weakness. +more | Including one virus in my mouth bringing sensitivity and tissue changes/patches along the side edges of my tongue which freaked the dentist out and almost made me get a biopsy for cancer. Cleared after 3 months, my tongue remains sensitive. The injection location on my arm stayed red and swollen the same amount of time I had these viruses, then disappeared. Strep-like. I had in my lifetime a previous bout of Epstein Barr and the theory is the injection lowered my immunity enough to reactivate mono. I am not dissatisfied, but I cannot take 3 months of that after each injection. Also an unusual finding showed up on my bloodwork about a month after injection, which was never there before, called monoclonal gammopathy which can be a precursor to multiple myeloma. Like others, I had increased, significant lower leg pain this year- bone pain. I attributed it to my osteoarthritis, but I am wondering if the increase in pain and weakness in my legs was caused by the Prolia. I am hesitant to blame Prolia because along with osteoporosis I have Degenerative disease in my spine and other related issues. From reviews on here I expected big spikes in my pre standing pain, but I only experienced my normal pain except my legs increased. I have enough issues without new ones, so after I talked with the dentist (I have some pre standing dental issues) and enough things to focus on wellness already.I will Instead focus on Vitamin D and K2 supplementation along with weight bearing activity | F | 56 | 1 times Standard i | 1/17/2016 | 2 | Told I had Osteoporosis | Flu like symptoms and aching all over that began about 2 hours following the injection and lasted about 3 days. A few weeks later I began to experience severe fatigue. It is debilitating. I'm so tired that even getting out of bed is an effort. I hope this tiredness will go away soon. | I am due for my 2nd dose in June 2017 but I am going to refuse it. I know my provider will be unhappy but to me the side effects out weigh any benefit this drug could provide. | F | 64 | 1 times 60 mg | 1/11/2017 |
PROLIA (DENOSUMAB): Denosumab is used to treat bone loss (osteoporosis) in women who are at high risk for bone fracture after menopause. It is also used to treat bone loss in men who are at high risk for bone fracture. Osteoporosis causes bones to become thinner and break more easily. Your chance of developing osteoporosis increases after menopause (in women), as you age, if someone in your family has osteoporosis, or if you take corticosteroid medications (such as prednisone) for long periods. Denosumab is also used to treat bone loss in women who are at high risk for bone fracture while receiving certain treatments for breast cancer. Denosumab is also used to treat bone loss in men who are at high risk of bone fracture while receiving certain treatments for prostate cancer that has not spread to other parts of the body. This medication works by slowing bone loss to help maintain strong bones and reduce the risk of broken bones (fractures). Denosumab belongs to a class of drugs called monoclonal antibodies. It prevents certain cells in the body (osteoclasts) from breaking down bone. (Sources: U.S. Centers for Medicare Services, FDA)