PARNATE Reviews (TRANYLCYPROMINE SULFATE)

Average Rating: 4.1 (143 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

PARNATE  (TRANYLCYPROMINE SULFATE):  Tranylcypromine is an antidepressant (monoamine oxidase inhibitor). This medication treats depression by restoring the balance of certain natural substances (neurotransmitters) in the brain. Tranylcypromine can improve your mood and feelings of well-being. Usually, this medication is used in persons who have not responded to treatment with other drugs.   FDA Approval Date: 1985-08-16 (Sources: U.S. Centers for Medicare Services, FDA)

  

Results are sorted by Date added.

Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

Page: 1 2 3 4 5 6 7 8


RATING  REASONSIDE EFFECTS FOR PARNATECOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 5  Depression Sexual side effect, last about 12 hours after a does. (male) Works well. Best with a very small does of an antipsychotic. ( 2,5 mg every other day/ Zyprexa) Weight gain 15 pounds. would rate 4.5 with the sexual side effect for a male. M 70 11 years
60 mgs 1X day
2/23/2024
Email
 5  Depression Some insomnia. It saved my life -- no, it gave me a life for the first time. M 65 30 years
30 mmg 4X day
8/27/2023
Email
 5  major depression disorder/anxiety When I take all 3 10mg pills at once in the morning can get light headed if I extert myself physically until early afternoon.. especially if I drink coffee. I have found taking my 3 pills a couple hours apart.. 7am, 10am, 12pm makes a huge difference. I can run up flights of stairs/run down the street/ work out at the gym no problem. I have some slight insomnia. Other than that no side effects! I have never had any reactions with any food. Parnate saved my life. There is no better way to say it. SSRI's I took for 26yrs stopped working. I found myself back in a suicidal depression/anxiety again after 26 great years. I was trialed on many medications first by my doctor and then by a clinician/research scientist at a mood disorders wing of the hospital. After a excruciating year and a half Parnate was tried. Parnate was the last med the clinician/scientist at the hospital tried befor it was time to try Ketamine, ECT or rTMS. Wish it was the first! About 2 weeks in I woke up one morning and felt that first lift in mood and anxiety. Within a month I was back. It works so well. For 2 years now I've been loving work and life is really nice again( with the normal ups and downs of living) and me and my loved ones are so happy and relieved! Depression such a dangerous brain health issue. It is not just my life that would have been lost. The lives of the people who love, need and care about me would have been changed forever if I couldn't keep fighting and had to pack it in. Yet, many doctors don't even know about Parnate or other MAOI's. The side effects food interactions are so over played that some doctors who know about them won't prescribe them. Well, Depression has side affects too folks! It's called death by suicide. It's called, my life and my partners life is in ruins. I suppose it won't work for everyone but everyone with untreated/treatment resistant Depression should please give it a goid try. M 57 2 years
10mg 3X day
7/11/2023
 5  atypical depression, social anxiety Constipation, orthostatic hypotension, fatique ( until i reached 50 mg), appetite suppression, bloating, sleeping troubles Like most others, I had to go through a whole spectrum of drugs (between 20 and 25) before being offered an MAOi. My psychiatrist no longer knew what to do with me because I had atypical treatment resistant depression, social anxiety (I didn't leave the house almost anywhere for 2 years). I was afraid of people, and I had no will, desire, or motivation to do anything but sleep. i have also been diagnosed with generalized anxiety disorder, ADD, fibromyalgia and worst of all anhedonia. Anhedonia is a state when nothing makes you happy, you have no motivation, no desire to socialize, no energy and the only thing you feel is anger. You start abusing various drugs. These drugs were mostly stimulants. Adderall, Modafinil, Dexedrine (it was the best for me). then I realized that the hormone of happiness is not serotonin, but dopamine and that the Mao inhibitor is what I need. I am currently on 60 mg of Parnata, xanax, 225 mg of Lyrica and rotate between Modafinil and Dexedrine).Thanks to God, my family and Parnate I feel 80% better than before.. M 34 1 years
3x20 mg 3X day
7/6/2023
Email
 3  Depression and anxiety I started Parnate in hospital. I went 10-30mg over one week and then a week or so at 30mg / I was so on edge and angry and aggressive. Felt like my whole body was being hijacked. I was reduced to 20mg and it made a big difference. Things calmed down and I could leave It has given me fatigue, dizziness, agitation, anger and irritable. However I have had some moments after dosing of feeing calmer and less anxious and better mood. I Recently (dec 2022) went up again to 25. It has been difficult again even with 5mg increase. Feeling tension and agitation and impatient and irritable. It's been 6 weeks to the day, Boxing Day 2022. Still not sure whether I will or can continue to raise the dose to 30. Have added email. Any advice welcome or questions M 46 6 weeks
25mg 1X day
12/25/2022
Email
 2  Depression Drowsiness and agitation especially in the morning even after a good night of rest. No improvement in depression yet but going to continue another month or two. I wrecked my car running into someone else. I'm very spacey feeling with lack of energy. I never saw the other car. Two days later I pulled out in front of someone never seeing them but thankfully didn't wreck. F 47 30 days
40mg 1X day
11/4/2022
Email
 5  Depression Slight insomnia I have been seeing Psychiatrists for 25 years. Bad reactions to every SSRI's and SNRI's I tried. Cymbalta gave me severe suicide thoughts, only time I have every had such thoughts. And the medical profession say MAOI's are dangerous and these drugs aren't? From my own research (search Dr Ken Gillman MAOI) I wanted to try MAOI's. Could not find a Psychiatrist to prescribe it, finally convinced one to give it a trial. It has changed my life, happy motivated, its a joy to be alive. I have slight insomnia, but it is a pleasure lying awake reading or having happy thoughts rather than dread and anxiety. The Pharmaceutical companies have a lot to answer for, they have spread misinformation about these drugs to sell their latest in patent drugs that don't work. M 62 3 months
40 1X day
10/27/2021
 4  Depression Some dizziness at first. Sexual side effect for about 10 hours after morning dose. The main MAOI drugs (Parnate & Nardil) for depression are the best antidepression meds on the market today. They get a very high rating because they work very well. Some people need a kicker ...so may need to another drug also. I had a debilitating depression for many years before Parnate.The schooling on these drugs are they have back side effect and you need a special diet. Its is blown out of proportion for a reason. These drugs were made in the 1950's and the pharm drug companies can not make any money on them now. Its a sin that relief is here but the docs are told not to use them. Find a dr that will. End the pain. good luck. M 65 7 years
50 MG 1X day
6/8/2021
 4  Major depression Dry mouth, muscle pain especially at neck and shoulders with higher doses, extremely tired at times, liw BP, dizzy, insomnia It does actually work and ive tried almost everything else except ect. F 34 1 years
40mg 1X day
2/26/2021
 5  Depression / anxiety Insomnia / Sleep disruption. Afternoon somnolence/fatigue. This is an absolute powerful antidepressant and anxiolytic drug. Here is the real deal: Annoying side effects Parnate = SSRI/SNRI (unfortunatly). Antidepressant/anxiolytic effects Parnate !> SSRI/SNRI. Take this if you have so called "TRD". M 33 8 years
30 mg 1X day
1/7/2021
 4  Depression and anxiety Parnate has helped me tremendously with my depression and anxiety. I am resistant to most antidepressants so was relieved when this worked. I had alot of side affects initially but it levelled out after 2 months. F 47 7 months
20 2X day
12/10/2020
Email
 5  Major depression and anxiety Insomnia, tiredness mid afternoon, restless legs. Parnate has absolutely changed my life. I've tried so many other medications and none of them helped. It gave me the confidence to have a child - something I put off because of my constant struggle to just get through the day. After seeking expert advice, I also breastfed. I now have a kind-hearted, happy, healthy and intelligent 3yo. I've also undergone 2 major surgeries while on parnate, with no interactions thanks to an amazing anaesthetist. The biggest issue I've had is when my prescribing GP moved away for a year - every other GP I saw wanted to take me off it because they had no experience with it. It's also been difficult to explain dietary requirements to others, even when staying at the hospital. F 39 5 years
2X day
12/9/2020
Email
 5  Treatment resistant depression Insomnia. Very pronounced at first, gradually less so, but still an issue after 10 months. BUT: parnate is a miracle and I feel more human than ever after 58 years. Will work out insomnia. Depression: gone!! Issues with dietary restrictions are absolutely minimal here in 2020, mostly avoid lots of aged cheeses. M 58 11 months
40 MG 2X day
10/14/2020
Email
 5  Depression No side effects for me other then insomnia which I took medication for but now. The insomnia has gone and I sleep perfectly fine with no medication. Absolutely destroyed my depression when ssri and ssnri and tricyclics barley took the edge off it. No my invisible heavy black cloak is gone and I've got a spring in my step . Wasted 20 decades on useless medication. Don't make the same mistake as me if you are only partially okay then try Parnate or Nardil. M 42 1 years
50mg 2X day
7/31/2020
 4  Major Depression- Severe, Recurrent Low Blood Pressure, Unpleasant Taste in Mouth, Increased Thirst, Muscle Jerks in Pectorals, Periodic Insomnia / Exhaustion, Increased Libido, Cessation of Nocturnal Emissions Takes 8 -9 weeks to work for me. Extremely effective against severe depression. M 33 3 years
30mg
6/27/2020
 5  Depression and Anxiety Very occasional dizziness due low blood pressure. Excellent drug. Have been dealing with my depression and anxiety for 24 years. Parnate has resulted in a major improvement in my mood and anxiety. In combination with two other drugs, my mood is now normal most of the time and has been so for over three years. The dietary restrictions associated with Parnate are very minor and I have found them no problem (although I had to change my choice of pizza). M 60 3 years
40 mg 4X day
3/6/2019
 5  MDD Fatigue, insomnia. Only AD that works. M 40 5 years
30mg
7/28/2018
 5  Depression M 45 5 years
40
12/24/2017
 4  atypical depression Dizziness upon standing (my systolic blood pressure drops about 30-40 points). Constipation (can’t go for over a week usually). Severe insomnia despite time of taking daily dose (I will take it at 5:30 am and still only sleep about 2 hours per night and be wide awake the rest). Extreme daytime sleepiness (in the middle of the afternoon, after my morning burst of energy wears off from taking the medicine, I feel almost narcoleptic, like I could fall asleep at any time.) Dry mouth is worse in the morning after taking dose but mints and gum help. I am a young adult and have tried at least 15 different antidepressants, mood stabilizers, anti anxieties, and parnate has been a life changer. It is worth the side effects to me. I still eat fresh cheese (American and mozzarella) but stay away from cheddar completely. I do not drink beer or wine but do drink liquor and haven’t had any issues. The only problem I had was when my psychiatrist prescribed trazodone to help with my insomnia, I developed serotonin syndrome and had to be hospitalized. He started me on a very low dose as a precaution and many other people take an MAOI and trazodone together with no issues, I was just sensitive. Now I take lunesta for sleep and it helps some nights but I still struggle with waking up very very early and never being able to fall back asleep. F 24 1 years
30mg
12/21/2017
 5  Depression with anxiety Some dizziness when looking up; urinary hesitation; periodic numbness and tingling;some ankle swelling; knee joint pain; feeling of being cold without being cold Brought complete relief from year long episode of numbing, horrible depression within 3 weeks of starting. Multiple other antidepressants were totally ineffective, as were 12 ketamine infusions. Ketamine did provide temporary relief but that faded with the last couple of treatments. I wish my doctor had tried parnate much sooner because it has brought about a total remission of symptoms and given me back a normal, positive life. Dietary restrictions are no big deal, although I did miss my sauerkraut at Thanksgiving! The episode of depression was about my tenth, first one in college, interrupting an otherwise happy, productive life. Strong genetic component in my episodes. Parnate rules! Any sufferer who hasn't done so needs to check out the inspiring work of Dr. Ken Gillman, a wonderful proponent of MAO inhibitors. It has been tremendously helpful. M 70 60 days
40 MG
12/10/2017
Email
  

PARNATE  (TRANYLCYPROMINE SULFATE):  Tranylcypromine is an antidepressant (monoamine oxidase inhibitor). This medication treats depression by restoring the balance of certain natural substances (neurotransmitters) in the brain. Tranylcypromine can improve your mood and feelings of well-being. Usually, this medication is used in persons who have not responded to treatment with other drugs.   FDA Approval Date: 1985-08-16 (Sources: U.S. Centers for Medicare Services, FDA)

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