Drug Ratings for DEPO-MEDROL

Average Rating: 2.2 (112 Ratings)

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)   

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    Charts & graphs: Reviews Summary for DEPO-MEDROL  | Top 10 Adverse Effects (reported to FDA)

RATING  REASONSIDE EFFECTS FOR DEPO-MEDROLCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
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 1  Neck pain for years I had this injection in my neck 5 weeks ago and have experienced horrible anxiety, panic attacks, skin crawling, agitation, irritability, weird dreams. I have researched extensively and have found no answers to how long these side effects will last. I did see that the mechanism of action is 1-5 weeks so I'm hoping that I can get stabalized and taken off the klonopin I have been prescribed which is the only thing working to keep my anxiety at bay. Don't ever get this injection done EVER, if I had known the possible risks and side effects I would have never gotten it done! 5 weeks and counting and still no relief in site. My psych doctor is hoping I can be stabalized for the next 2 weeks so I can hopefully start tapering down the klonopin and deal with all the lovely withdrawal effects!! Do your research people please before getting this done!! F 27 1 times
80
5/13/2017

 1  thoracic disc herniation Extremely high blood pressure. Racing heart. Faint. Made me insane. Loss of appetite. Motion sickness. Depression. Could not sleep. Skin crawly. Numb limbs. Extreme endocrine illness symptoms. Ear pressure. Eye pressure. Could not form sentences. could not think right. many many more awful symptoms for 4 months then alleviated a little at a time. I thought i was going to die. Never ever again for any reason! !!!!! F 46 1 days
160 mg
4/1/2017

 5  both knees Osteoarthriis Total relief from shot in each knee. No side effects. I have osteoarthritis and bone spurs in both knees with severe chronic pain and inability to walk or bike without legs locking and severe pain. A shot of Depo-Medrol in each knee lets me go back to free walking (without a cane) and bicycling without 99% of the pain. F 64 15 years
40 1X AN
3/24/2017

 1  Frozen shoulder I received one Depo shot for frozen shoulder in Nov 2016. Approx 1 week after that I experienced heart rate up to 140, anxiety, panic attacks, 10 lb weight loss, depression and insomnia. Went to my GP who said it was not from shot, blood work was normal, she prescribed ativan, which I did not take. Starting seeing a Naturalpathic who said my adrenal function is low, even though blood work is within normal(but on low side) and symptoms probably due to shot. I am now on mega B, C and stress vitamins and take skullcap for anxiety. I am 4 months out and the lingering side effects are anxiety/depression and occas panic attacks, which my naturalpathic and I are working on. I have never had any of these before and they are quite debilitating. I feel better overall but by no means 100%. I exercise and eat healthy and all of these things help I think. Alcohol and caffeine makes symptoms worse.I am just waiting out these lingering symptoms and hope they subside in time. 57 1 days
not sure 1X O
3/15/2017

 1  Intrathecal injection I noticed after having epidural injections that I was very very prone to gastrointestinal issues. I consistently get a flu-like illness every 4-6 weeks from the time I started this as part of my pain management routine. Without fail every few weeks I would have this "flu" that joined around me ever caught. I have nurses, family, support workers etc around me daily and no one had ever caught it. Symptoms would be: *nausea (severe) has to be controlled with IV administered through peripheral IV daily, along with gravol. That is how severe the nausea had gotten). Fever 100-103 Racing heart when standing 120+bpm (I assume it would go hand in hand with my next symptom) Orthostatic intolerance- no would bottom out when standing. Was low when sitting or supine however I didn't have the same effects from being supine or sitting, compared to standing. Unable to stay hydrated. Due to vomiting. Unable to get comfortable. I would get hot and cold sweats that would change every 2 min. Way too hot and soaked in sweat so take layers off and would be freezing before I could get a heavy sweater off. No appetite whatsoever. Started off at 135lbs and I'm 5'5 female. I was getting sick very frequently around Sept 2016... and over that last year i had finally gained a healthy weight. I was 135lbs. Its now march. 3 and I am 112lbs. I was so weak from this "flu" I was unable to get out of bed. It was terrible having this every few weeks for a ye F 33 8 months
1ml-2ml
3/3/2017

 1  Torn rotator cuff The 20yr old female that so confidently stated that side effects are short lived and go away, you are a moron! Common sense tells you that everyone is different and affected differently by numerous things. I had a disk removed and fusion of my cervical spine. When I awoke from surgery I felt amazing compared to the previous years of heavy arms and locked up muscles. One month later I was approved by neurosurgeon to have an injection of depo-medrol into my torn rotator cuff by the orthopedic surgeon. Afterwards I felt even better, the burning at top of shoulder was gone and I even expressed to my wife how amazing it was. By the end of the next day everything changed, my left side muscle in my neck became rock hard again and from top to bottom my trap muscle on left side was locked up also. Then my arm became very heavy and tired feeling. Then a few days later my sternum began to hurt very badly and the top side of my ribs were very tender to the touch. Eventually I couldn't pick up my 2yr old because I would get a traveling pain down left side of my back when I tried to lift her. It has now been almost 2 months since shot and I'm now taking Neurotin and muscle relaxers for minimal relief from the nonstop pain of constantly being locked up. This has been consuming my life. I have been depressed, angry, and dumbfounded that this shot has made me feel worse than before my surgery. My only hope is that since it is a 3 month interval shot that next month it will all stop. So 20yr old female, you're dumb as sh*t. M 37 1 days
1/6/2017

 1  Hip injection for pain After the injection in my left hip. It got worst. I cannot raise my leg. Hurts terribly to walk.cannot stand on it long. Bend I have limit mobility. This medicine needs to be taken off the market. F 60 1 days
12/22/2016

 1  Rotator cuff The shot relieved the pain in my shoulder but my blood pressure has soared, almost doubled, and my pulse randomly races to 100 or slows to 50. This is accompanied by a feeling of lightheadedness, fogginess and odd skin sensations ranging from itch to prickly sweat. It has now been two weeks and these side effects are showing no sign if diminishing. I would prefer to have shoulder pain. This is scaring the crap out of me. I've long been healthy with low BP. Don't do it. F 58 1 days
60 1X D
11/30/2016

 1  Allergies I got my shot a little over 24 hours ago and from the front of my head to the back and all the way down is severe pain. I'm having a very very hard time moving around. The only time it wasn't as bad is when I'm laying down in a certain position. F 17 1 days
80 MG
10/25/2016

 1  Allergies I got an injection of depo-medrol on Tuesday, 04 October 2016, and could not believe how great it made me feel within a day. I finally had some relief from my sinus pressure and allergies. However, by Sunday, 09 October 2016, my shoulder started hurting (it felt like bursitis because it was sore to the touch at the top of my shoulder). I didn't think much of it because I do have some arthritis and have had this issue before. But in the 2 next days, I started having feelings that I describe as blood sugar crashes, weakness, stress sweating, shakiness, upset stomach, and extreme fatigue. I even went to the ER because I thought I was having a heart attack. Thankfully, all my labs and EKG were normal, but the last few days have been hell. I started Googling depo-medrol to see if the side effects matched up with what I was experiencing. I never would have figured that this injection was what was causing all this (and I can't say for sure that it is, but it is the only medication that I've taken that is different; I suppose it could be the Biaxin I was given for my sinus infection, but I've taken it before with no side effects); however, after reading all the other comments from people who got the injection for allergies and had the same side effects, it feels like a God-send to know that there might be a reason for this. I thought I was going crazy. I'm so sorry for everyone that is having these issues, but I am happy to know that I'm not losing my mind. I just hope these nightmare side effects go away soon. I wish I would've just kept taking my Mucinex Sinus Max for the pressure and allergies and never had this injection. F 56 1 days
Not sure 1X D
10/14/2016

 1  Chronic Allergies Was given a single shot of DEPO for horrible chronic allergies 10 days ago. A few hours later my throat was a bit scratchy and my drainage had increased. The next day, everything went downhill. While my sinus symptoms greatly improved, the side effects, which I'm still coping with, are an absolute nightmare. Headaches, fatigue, cold hands and feet with strange muscle weakness plus pins and needles feeling, random body aches and pains, shortness of breath upon exertion, diahhrea with abdominal pain, and for 4 straight days a low grade fever. The kicker? Exactly a week after the shot, the sinus symptoms returned. Might be great for some people but I'll NEVER touch the stuff again. Note: Prednisone also screws me up hardcore. M 33 1 days
9/4/2016

 1  Rheumatoid Arthritis It made me feel strange, confused, crazy. One shot made my head and stomach hurt for three days and made it feel like every bone and joint in my body ache enough to the point...I almost went to the ER. I've been going to my Rheumatologist for over a year now and I hurt so bad and feel so bad from this shot, I will NEVER go back to her again. The site of injection had lumps and was so painful, my arm felt like it weighed 50 lbs for 3 or 4 straight days. I'm trying to figure out if this was some sort of allergic reaction?? Horrible experience! Would not recommend this drug! F 46 1 days
30
8/25/2016

 1  Severe seasonal allergy Did not help at all,could not focus trying to pack for vacation(have packed for years) very difficult crazy bad dreams,confusion waking up like you where in a dream Would NEVER take this drug again they say there are no side effects with this drug, I say they are crazy should certainly have precautions before taking it there are major side effects F 77 1 days
80 1X D
8/14/2016

 2  Severe seasonal allergy First, acute spike in blood pressure and heart rate, anxiety, difficulty sleeping (even sitting still), acid stomach, belching. Next day, alarming physical weakness, dizziness, depression. Starting that second night, heavy but unrestful sleep with unusually vivid, crazy, even revolting bad dreams (normally, I rarely even remember my dreams) with lingering gloom on waking. (Now I dread going to sleep!) Pain from hip injection much worse 3 days afterwards, despite hot baths and massaging the area; feels like my hip was hit with a sledge hammer! Depo-Medrol alleviated about 95% of my major allergy miseries in 24 hours, but then the "roller coaster" of very unpleasant side effects after that are a whole new bunch of miseries! I think next time I'll suffer through the allergy with more OTC meds rather than undergo these awful side effects again!! The doctor said this shot could give me amazing relief. Well, yes...and NO!!! M 65 1 days
80mg 1X D
8/8/2016

 5  Sciatica or extreme lower back pain No side effects I believe I suffer from sciatica. 6 months ago this happened and a doctor told me that's what it is. It's only in my back, I don't feel any discomfort in my legs or hips. Strictly lower back. Anyways, I couldn't tell you what happened but like a light switch, yesterday, my back started in. This morning, I couldn't dress myself. Literally. Couldn't walk normally, the worst, most extreme back pain I have ever experienced. I'm a nurse for a doctor and it occurred to me that could give myself this shot. The 5 or 6 800mg ibuprofen cut nothing. Advil, did nothing, bengay, nothing. No exaggeration, not one bit of relief. So, I got to work drew up the 1 ml of depo medrol and for good measure I drew up a nice 3mg of toradol. As fast as I could, I shot myself in my right deltoid muscle. About 2 minutes later I could walk normally. My back was still tight but a good 80% of the pain was gone. It's now 645pm and I'm still very comfortable. Little tight but pain is minimal. I gave myself these shots at about 745am. F 32 1 days
1ml
6/23/2016

 5  Severe rash on hands and feet No side effects only relief! I've had a horrible rash almost like poison ivy/oak. Derm says it is contact dermatitis. I've gone to walk in clinics and demand a shot of Depo instead of other steroids. The rash completely goes away for approximately 45 days. After steroid wares off rash comes back. Once itches is unbearable after 2 to 3 weeks I go on the hunt for a new walk in clinic that will give me an a shot of Depo I ask for 2 ml of 40 mg and I'm good for another 2 months.Most amazing drug. I know you shouldn't use this med for long periods of time but the pros and cons I choose no rash. M 33 2 years
2ml of 40m
6/14/2016

 2  Joint pain No side effects. No pain relief after injection. Three days after infection pain not any . Pain is worse F 65 1 days
injection
6/10/2016

 4  Low back and sacrum pain injections This was a one time injection given by my pain doctor in his office. After two weeks I got a terrible itching rash that spread from my arms to my stomach, legs, back, neck, and buttocks. It has been going on for 4 weeks. Went to a dermatologist who put me on prednisone to relieve these symptoms. Still have them and my course of prednisone will end in 3 days. I cannot sleep at night because of the itching. The rash is horrible! I have had a terrible allergic reaction to this steroid. There are many different types of steroids that doctors use for pain relief and I will never use depo medrol again in my life. This is agony! F 61 1 days
1cc
3/2/2016

 1  Knee pain Insomia back pain shoulder pain axiety stress I will not take it again. Im afraid of the effects now F 51 1 weeks
40 mg
2/14/2016

 1  Knee pain Insomia back pain shoulder pain axiety stress I will not take it again. Im afraid of the effects wow F 51 1 weeks
40 mg
2/14/2016

 4  Seronegative RA Facial flushing, hot feeling in face, and itching of face, neck, and arms. I got an injection of depo-medrol for a flare up of RA. It helped the swelling and pain in my hands but the side effects were quite unexpected. I took Benedryl for it and the itching went away but my face is still red (two days after). Hopefully that is just temporary. F 36 1 days
2/7/2016

 5  RA & Osteoarthritis Solu-Medrol have relieved my pain and swelling now for years I look forward to for my monthly shot of relief. Though it has caused me to gain weight. It is my wonder drug. After your system get use to it side effect vanishes. F 63 4 years
100 mg
1/17/2016

 1  just normal form of birth control. Period for 4 weeks. Bv infection yeast infection soreness everywhere itching. Uti. Terrible mood swings. Dryness as in skin and vagina. Legs hurt and tingle. Depression. Hotflashes. Bad cramps back hurt. head hurt on and off. Stressed! Gained a lot of weight then lost it and barely eat. Crying so much. Joint pain along with bone pain. Stomach belly button area hurt. Under rub cages kinda hurt. And a feeling of getting pricked with a needle mostly in my legs and sometimes other area of the body. I went on this hoping things would be great but no they suck this is not for me or my body. I barely eat or drink water. I got a on and off Uti which i never had. I'm paranoid and have so many panic attacks everyday. Cause something new will be going on with my body. I want it out my body so bad. Some people body can take this. My best friend cool all that happened to her is she spots and sleep more. But not my sensitive body. I dont if its the shot thats doing all This but my body cant take it. I cant wait for it to be over. So i can stop going to the doctor and spending all my money on that F 21 1 months
every 3mon
1/17/2016

 1  swollen glands Burning sensation in face,and arms anxiety Feeling like i was poisoned I told my doctor something was wrong because i lost my appetite and 14 lbs in a couple weeks..i feel worst than before he gave me the shot.. F 38 1 days
80mg
1/5/2016

 1  Hives When our daughter was in college and getting ready for her wedding she had unexplained hives. Went to doctors and the nurse gave her a kenalog injection not in the hip in case of side effect but in the arm. She had the side effect of muscle wasting at the injection site. Not good when you are about to get married and in a sleeveless dress. We visited the doctors office not to sue but to advise and work a solution out. We asked them to pay for what our insurance did not cover to have it fixed. They did, thank heavens. Our daughter had plastic surgery to repair. It fixed it and she has had no problems since. The plastic surgeon said sometimes it can recur even after surgery but it did not. That's been about 9 years ago. It was outpatient surgery. Steroid shots or Meds are Very risky. I'm sure they can help but can also hinder. Use your own judgement. We never found out the cause of her hives? Maybe nerves from upcoming wedding? Not sure. I would say be aware and proceed with extreme caution if you ever need to have an injection or need the medicine. F 21 1 days
60mg?
12/15/2015

 1  L5 s1 lower back and arthritic hip. My pain is much worse now than it was before I ever had the Injection I would never Have another injection of depo-medrol or Kenalog F 65 2 days
?
12/10/2015

 1  back pain Insomnia, blood pressure elevated and racing heart. Going on now for two weeks F 54 1 days
unknown
12/4/2015

 5  PMR Seronegative RA None at all. I have taken oral steroids & had the most awful side effects, so came off on a fast taper. Since having this steroid injection 7 weeks ago I feel normal again. No joint pain, sleeping properly. I've even managed to lose 19lbs since I had it. F 59 1 days
120MG
11/30/2015

 5  knee osteoarthritis None. The drug has been a miracle for me. Did not realize how much trouble I had walking before injection. F 70
40mg 1X D
9/9/2015

 4  Rheumatoid Arthritis Anxiety, hot flushes, stomach pain and nausea. ALL ARE TEMPORARY!! I have used various methods of steroids (infusions, oral, IM) and they all work great. Yes they do give you some unpleasant side effects but these are short term and what are they in comparison with extreme joint pain and stiffness?! The worst one personally experienced is anxiety. If you experience this, contact your GP and they can give you something to help. There are always drugs that can counter act the side effects so don't listen to the horror stories! Do what is best for you, don't be put off. F 20 6 years
120mg 1X AN
8/26/2015

 1  knee sprain The stiffness and soreness in my knee immediately returned. Like going back to square one. I only got the injection because I was going hiking for a week. The knee had nearly healed. A steroid shot had been recommended by another doctor for a previous sprain, and by friends who's had it. Instead of relieving the symptoms, it was like re-injuring the knee. M 65 9 days
1X AN
8/14/2015

 1  Seasonal allergy Irregular heart beat . Spiked Blood Pressure and anxiety. I would strongly recommend to avoid this unless you are really left with no choice. If I had known about these before I would have never taken them M 34 1 days
80
7/30/2015

 4  Knee osteoarthritis-degeneration Facial flushing; heartburn; irregular heartbeat All side effects from injection lasted only 2 days. The relief from my knee pain lasts almost 3 months. Get knees injected every 3 months for past 3 years and it is still working. Can put off knee replacement until injections no longer work. F 69 3 years
1X O
7/7/2015

 1  Allergies I was given the shot about 2 weeks ago and immediate reacted in doctors office with almost passing out, heart pounding and racing, and shaking uncontrollably. They gave me a shot of Benedryl which helped calm me down but have been in ER 2 times since with racing heart, feeling faint, BP has been up since and sugar elevated which I have never really had these symptoms until I took the shot. I hope this passes soon! They say I may have developed a anxiety disorder as a result. Try everything before taking a shot of this crap! M 39 1 days
40
5/26/2015

 1  pain Very sick raised my blood pressure very very high my heart beating very fast my stamach sollen and side and the pain was in my left not my right side a rash on my arm and my right ankle burning with my gums sollen pain this is a very bad drug and the pain i haf the shot for is not even gone Drs should not use this for people in pain makes it worse now i just heard theres a recall on this drug so why did he use it that dr is going to get sued if i do not get better and so is the manfacturer. F 72 1 days
30mg
5/3/2015

 2  Severe hip arthritis None - just some soreness for a day or two I was diagnosed with severe arthritis in my hip and was told I'd need a hip replacement at some point. The doc said I could get relief from these shots until they didn't work anymore, at which point I'd probably want to go ahead with the hip replacement. I had one 80 mg shot under a fluoroscope in Aug 2014, and it gave me almost complete pain relief for 8 weeks. I had another shot in Nov 2014, and it gave me no relief. I had a third shot March 2015, and I had relief for about 4 days before the pain returned. I'm now talking about hip replacement with my doctor. F 40
80 1X O
3/16/2015

 4  Severe asthma I have severe asthma and take 2 inhalers, 2 pills and a nebulizer on a daily basis to breathe. I get an 80mg shot of Depomedrol once every 30 days without the shot I end up in the ER because I can't breathe. Yes I have gained weight and get itchy at the injection site but I will take that any day over not being able to breathe. My Asthma is so severe, without the shot I feel like I have an elephant on my chest and then a panic attack because I feel I will die The shot relieves all of that for about 30 days. They need to work on the weight gain issues because breathing and fat don't go well together F 42 3 years
80mg month
1/21/2015

 1  Neck pain I received 3 epidural injections of Depo Medrol. Once a week for 3 weeks. I had reaction after 3rd. Waiting 15 minutes after injection before leaving office. I had taken Valium before procedure and dozed off. When I woke after the alarm went off, I could not move any part of my body and barely able to move my mouth to talk. They rushed me to room with oxygen etc and it took abt an hr and half before I had feeling again. I asked doctor what had happened. He said not sure maybe a reaction to numbing injection. Well after 1st injection severe pain at neck and unusual eating habits. I told doctor on 2nd visit. He said wow that's odd. 2nd injection I told him the same. No response. Well after the 3 they called and cancelled my 4th. So now 6 weeks later...i have gained 30 lbs, difficulty breathing, pain in whole body especially legs. I have had severe cognitive issues. Not remembering short term things especially. It seems some things have improve d, but others keep getting worse. I was 117 lbs when I started these epis. Now I'm miserable in pain and depressed. Does anyone know how long these epidurals stay in your system? F 40 3 weeks
50 mg
12/3/2014

 1  hayfever I was giving depo medrone in jun 13 Oct 13 I noticed a dent in my hip now a year on its getting bigger I.v had xrays all was clear I am now getting physio to try and bulk my muscle back out but I am not happy as it might not work as my physio has told me.. Has anyone sued doctor or company for this side effect???????? I can't wear a fitted dress because you can see the dent in my hip 😞 I hate what it's done to me F 27 1 days
11/20/2014

 1  Allergies EXTREME insomnia, EXTEME fatigue, anxiety, increased libido but unable to climax, the list goes on and on. My allergies became out of control while moving house (dust) so after a week of suffering I went to the dr hoping to get some relief. This was 2 days ago. I have had no relief from my allergies but that now fades into insignificance to the issues I now have. I have not slept since having the injection and have now been awake for more than 2 days. I can get a few minutes of dozing sleep in which I have strange dreams but can't get any deep sleep. Doing anything is very difficult even basic daily tasks. All I want to do is sleep but can't. I had to defer my uni exams because I am very sick and have no focus. My libido is out of control but I can't climax, this is very strange and frustrating. I have never felt worse and am very worried about what's to come. This drug is poison. Do not go near it with a 50 foot barge pole. I went back to my dr today who said that there are no side effects with this drug. What a load of crap! She even offered to give me another 40mg dose to try and help with my allergies to which I said NO!!!!! I would jump off a bridge before I would be injected with this poison again. STAY AWAY FROM THIS DRUG. If this post helps one person not to go near this drug it will be worthwhile. F 31 1 days
40mg 1X D
10/24/2014

 4  Fibro, RA, OA, stenosis & sciatica Don't heal as quickly. Reduced sinus swelling, allergies better. Happened to Get shot in hip w/bursa swelling (20+yrs)- better, pain in lower back - better, pain from Fibro - less & less flares, arth pain - better & better life because of less pain, better motion & emotion! I live the life - 40yrs Fibro & back/hip pain many of u describe as side effect. I'm sorry that maybe dosage wrong or whatever reason it was a bad experience for u. I am so grateful my Dr cared enough to find something that helped me. I have to wait 30 more days, he says not good to take more than 3x's a yr, & I am counting down the days! F 56 6 months
20
9/2/2014

 1  BronchoSpasm (Asthma) I've had depo before and it never did this to me before. Extremely rapid heart beat, irregular heart beats, and fluttering heart with any movement (no endurance). Shallow breathing. Could not walk far without feeling my heart was about to burst. Could not swat a fly without my heart overreacting and going wild. Slightest emotion caused my heart to go wild. Felt like acid or fire running through my arm and neck veins. Twice I almost died. Felt like I was in the 7th circle of hell! Felt like fire, then antifreeze, running through every cell of my body with rapid heart. Muscle weakness. It has been 20 days since receiving the shot and I'm still having symptoms. Have not been able to walk through a department store without feeling like my heart can't handle it. Going to have a heart ultrasound to ensure depomedrol didn't blow my valves. Having been praying like crazy to get well. This stuff is poison! Never again!!! (He should have just given me steroids by mouth.) The labs making this stuff need to be inspected and cleaned up! F 57 1 days
80 mg 1X D
8/21/2014

 1  pain. I recieved shot Rash 2 week then got rash week later F 1 days
40 mg
6/3/2014

 1  Facet Joint Arthritis PANIC, ANXIETY, DEPRESSION, SKIN BURNING, HOT FLASHES, INSOMNIA THAT CAUSED WEIRD SEIZURE MOVEMENTS AFTER GOING DAYS WITHOUT SLEEP, ER VISITS, HOT FLASHES, PERIODS WENT CRAZY FOR MONTHS AND MONTHS!! NEEDED BENZO VALIUM TO KEEP FROM GOING INSANE!! I HATE BEING STUCK ON VALIUM!! Was FINE before shot!! Slept well, no anxiety before or during periods, no anxiety PERIOD!! The night of the shot I woke up with my whole body flushing..like my skin was on fire. I was BEGGING Jesus to help me. I began to have a panic attack, could not sleep, and felt like I was going to die. I suffered it out the night, got a little better, then thought drinking water would "FLUSH" the med...NOT!! I was told by family to give it a few days. I did not sleep and kept having SEVERE panic while trying to sleep. My body was jerking, felt like I was dying. After day two I went to the ER, the Doc felt really bad for me and said it WAS the steroid shot, and I would most likely feel better in a few weeks. NOPE!! In and out of a few ER's after going 3 days with no sleep each time and the anxiety was AWFUL!! Primary care doc told me to take some valium to help; it did a little but not much. She said some people have had this happen, but after a few months it goes away. Well...I am STILL suffering 1 year and 3 months later. After the first three months post injection, I HAD to find a psych dr., I have bad reactions to SSRI's and other psych meds apart from Valium...so he prescribed 5mg a day. After a week, I felt, ok so I thought I would ween off...BAD idea; symptoms came back. Tried to go back up on 5mg, but it no longer worked. Had to up to 10mg. Stayed on that for about 10 months or so, even on that dose...I had issues before and during my period with worse anxiety and s F 38 1 days
80mg 1X D
4/27/2014

 1  Injected in foot for pain An hour after injection, I was on floor crying in pain. I had muscle spasms in my back for days, it was horrible the worst pain I have ever had. My dr told me it had nothing to do with shot and I will strongly disagree with that! F 17 1 days
3/17/2014

 2  shouler pain torn labrum Had injections twice within a 4 month peroid. Servere cramping of all muscles. orthapedic doctor who did injections NEVER informed me of SIDE EFFECTS or AFTER CARE let alone what he was injecting! I think these injections are used very recklessly and are doing far more damage than good. After second injection ring finger has gone totally numb. Also pain in kidneys. M 43 1 days
injection
2/12/2014

 4  Inflammatory arthritis Headaches and soreness at injection site but only for a couple of days. Each dose lasts around 6 weeks each to help especially the pain and inflammation and fatigue F 37 2 months
120mg
12/31/2013

 3  severe scalp psoroasis I had to get this injection because my scalp psoriasis was severely flared so I went to urgent care and that is when I heard of this injection. The Dr was explaining the shot to me and how it will work, he said it surpresses the immune system so I asked does that mean i m gonna get sick he said no its not as bad as it sounds so I got the shot Monday night Tuesday I woke up feeling great my head was so much better... Wednesday I woke up in the worse pain ever with strep throat fever flu symptoms... Thursday even worse than Wednesday so I went back to urgent care they said I got sick because the depo medrol surpresses ur immune system and I said I knew it was gonna happen so the gave me antibiotic injection and today is Saturday and its not as bad but it still hurts to swallow and my teeth seem sensitive hmmm kinda weird. I really don't know what was worse the psoriasis or my body feeling like I got hit by a bus... I still keep looking up as things could be worse. F 27 1 days
80mg
12/7/2013

 1  Legg-Calve-Perthes Disease Hip pain Had injection in hip joint for pain related to childhood bone disease. It has been causing arthritis in the hip and residual pain in my back. Right after shot was limping. Lidocaine used with injection made no difference, increased pain began immediately and worsened. Can't find a comfortable position to stand, sit, or lay in. Pain is intolerable from my hip the whole way down to the middle of my calf. Muscles feel sore and achy, knee joint hurts when still or bending. At some points leg cannot bear any weight. Have tried both NSAID and narcotic pain relievers with no success. Was told this "doesn't generally happen" and clearly, from the ratings on this site and others, it does happen. Just say no!!! F 28 1 days
20mg
10/30/2013

 1  wrist pain Pain in my hand and arm..got worse each day. I took the shot about a week ago. And the pain is worse when I make a first with my hand. F 23 1 days
40mg
9/11/2013

 1  shoulder pain I was given a shot of this in my shoulder. Within 2 days i developed severe anxiety, heart palps,cramps in both legs,both arms,extreme next and upper back pain,eye twitching,ears ringing,chin and left face twitching,burning mouth and tounge,lips,weight loss, blue toes...For eight months these symptoms went on. It is now a year and my mouth still burns and face still feels odd. Countless doctors,spinal tap yielded nothing. No doctor but my dentist will admit it was the depo medrol. Very active woman who is an endurance horse rider and runner. Life was nearly shattered because of this drug! F 48 1 days
80mg
8/26/2013

 1  Knee Pain I have taken this injection in my left knee, after taking injection within half-an hours time it was reacted, I got swelling complete knee area and sevior pain, and muscle was weaken. Now I am suffering with 10 times more pain than compared to before taking this injection, after two months also the swelling was not gone. Be aware before taking this injection. M 38 2 months
1X O
8/22/2013

 1  intramuscular injection/back pain Total body melt down and over a year later, still have side effects. Vision problems, nerve pain all over, weight loss, hair loss, digestive issues, continuous menstrual bleeding for about 8 months, the list goes on . . . seriously frightening medication. Be careful with this medication, do your homework in advance. To the angry reviewer a couple of reviews down, berating women for confusing Depo Medrol with some other drug, sounds like you're having some steroid rage issues. Yet another common side effect. F 33 1 days
40 1X D
7/1/2013

 5  Spring season allergy Increase of libido M 51 5 years
5/4/2013

 3  Allergic reaction to antibiotics First of all, all you young women on here bashing this drug because you claim you used it for "contraception"...get off the Internet, pay attention at your practitioner's office and find out what you are REALLY putting in your body. You're so damned ignorant! Depo medrol is a corticosteroid, not a contraceptive. You women are probably on Depo-provera which is A COMPLETELY different type of drug. If you morons payed more attention to what's going on perhaps you would be in better health, rather than broadcasting your stupidity over the Internet. F 32 1 days
4/29/2013

 5  Rheumatoid arthritis Is the only drug to get my RA under control suring pregnancy, while breastfeeding and until my other drugs kick in. If you are complaining about the side effects you obviously didnt need it to start with. F 2 years
120mg 1X M
2/21/2013

 1  Thumb Tendonitis Complete numbness of thumb for 3 days, after which I lost about 60% of sensation in my WHOLE body, particularly my scalp, face, neck, teeth, butt and back. Doctor says that my symptoms have nothing to do with the injection, but the numbness spread from my thumb all over my body. It has been a week now and I am not regaining sensation. I am very nervous and hope that something wasn't seriously damaged. I can't tell if my tendonitis is better because I can't quite feel anything on my body. F 30 1 days
unsure 1X O
12/11/2012

 1  Allergy-Poison OAK I got the shot in my hip. The next day my back started hurting. It's been three days now, I still have my Allergy and my back feels as though its being crushed. I am in so much pain! Almost constant muscle spasms in the mid section by spine and rib area. F 44 1 days
40 MG 1X D
12/10/2012

 2  Pleurisy I had an allergic reaction to this medicine. I got a fever and chills from it and now I have pain in the injection site that has not gone away. It hurts really bad to touch the spot. F 22 1 days
80 ml
12/7/2012

 1  supposed trigger point in back Update from 7.5.12, 7.10.12, 7.18.12 postings: side effects of pain in extremities persist as well as extreme fatigue and muscle weakness. Also, the injection had no therapeutic effect whatsoever. It seems there is a common, scenario - what I experienced along with many others - that makes me wonder about the competence of doctors who administer these injections: doctors not informing patients in advance about possible long-term, serious side effects; doctors being far too cavalier in administering these injections; doctors denying side effects patients experience (some patients are told that they have "anxiety issues" or it's all in their heads! - read reviews elsewhere, the level of medical incompetence is truly amazing); and doctors being completely uneducated about side effects. PLEASE, everyone who has experienced serious adverse reactions to corticosteroid injections, file a report with the FDA: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053074.htm or call the FDA at 1-800-FDA-1088 to report by telephone. I had trouble filing online and sent a hardcopy to the FDA (which was acknowledged by letter from the FDA). Lawsuits are very difficult to bring, and the only way to force responsible administration of these potent drugs is for EVERYONE who has suffered serious side effects to report to the FDA. Corticosteroid use (abuse) is now booming business for doctors and drug companies, and it seems that the administration of these drugs has become unbelievably irresponsible. MANY people are suffering from the cavalier administration of corticosteroid injections and you can help put an end to the irresponsible administration of these medications by reporting your experience to the FDA. F 44 1 days
20 mg 1X D
9/29/2012

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